BOC-D-FMK|1mg|abs818554-爱必信(上海)生物科技有限公司

BOC-D-FMK

参考价：¥924

供货周期：

一周

品牌：

爱必信

规格：

1mg

货号：

abs818554

CAS号：

634911-80-1

产品详情

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产品描述：

产品名称：BOC-D-FMK

参考文献: [1]. Landgraeber S, et al. Pan-caspase inhibition suppresses polyethylene particle-induced osteolysis. Apoptosis. 2009 Feb;14(2):173-81. [2]. Grigoryan RS, et al. Flow cytometry analysis of single-strand DNA damage in neuroblastoma cell lines using the F7-26 monoclonal antibody. Cytometry A. 2007 Nov;71(11):951-60. [3]. Yee SB, et al. zVAD-fmk, unlike BocD-fmk, does not inhibit caspase-6 acting on 14-3-3/Bad pathway in apoptosis of p815 mastocytoma cells. Exp Mol Med. 2006 Dec 31;38(6):634-42.

CAS号: 634911-80-1

靶点: Caspase

描述:

Boc-D-FMK是可渗透细胞，不可逆的，泛半胱天冬酶抑制剂。抑制TNF-α诱导的细胞凋亡的IC50值为39 μM。

In vitro(体外研究): Apoptosis is a pathway of cell death orchestrated by a family of proteases called caspases. Boc-D-fmk inhibits TNFα-stimulated reactive oxygen species (ROS) generation. Boc-D-FMK inhibits apoptosis stimulated by TNF-α with an IC50 of 39 μM. BocD-fmk at 50 μM prevents genistein-induced apoptosis of p815 cells. Confocal microscopy shows that the release of mitochondrial apoptotic factors is inhibited by BocD-fmk.

分子式: C₁₁H₁₈FNO₅

In vivo(体内研究): Boc-D-FMK-fmk effectively attenuates the hepatocyte apoptosis in bile duct-ligated rats and may improve the survival rates after endotoxin challenge. A single injection of Boc-D-FMK results in longterm protection of MNs against root avulsion-induced death for more than 8 weeks and the Boc-D-FMK-treated MNs are able to regenerate their axons into an implanted PN graft and reinnervate the target muscle.

分子量: 263.26

纯度: ＞95%

储存/保存方法: Store at -20°C

可溶性/溶解性: DMSO: ≥ 125 mg/mL

产品信息订购：

产品货号	产品名称	规格	价格	大包装及货期
abs818554	BOC-D-FMK	1mg	924.00	立即咨询
abs818554	BOC-D-FMK	5mg	1612.00	立即咨询

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