产品详情
Product Name: Minocycline hydrochloride
别名: | 二甲胺四环素盐酸盐 ;盐酸米诺环素,盐酸二甲胺四环素,4,7-双(二甲氨基)-1,4,4a,5,5a,6,11,12a-八氢弹0,12,12a-四氧基-1,11-二氧-2-并四苯羧酰胺 |
CAS号: | 13614-98-7 |
分子式: | C23H27N3O7.HCl |
分子量: | 493.94 |
EINECS编号: | 237-099-7 |
MDL号: | MFCD00083669 |
介绍: | 溶于水,遇光不稳定,味苦。 |
用途: | 抑制内皮细胞扩增和血管发生。 |
特定比重: | 1.017 |
贮存: | 储存温度2-8°C |
生化和生理学机理: | Minocycline is a tetracycline antibiotic with neuroprotective, antiapoptotic, anti-inflammatory and antimicrobial effects. Minocycline acts as a matrix metalloproteinase (MMP) inhibitor; attenuates disease severity in mouse models of multiple sclerosis. Minocycline also inhibit the enzymatic activity of poly(ADP-ribose) polymerase-1 (PARP-1) and angiogenesis. In addition, Minocycline is suggested to down-regulate CD40L on T cells and inhibit the replication of SIV and HIV. Orally active and brain penetrant. |