Gemcitabine hydrochloride is used for treatment of non-small cell lung cancer, pancreatic cancer, mammary cancer, ovarian cancer, bladder cancer, nasopharyngeal carcinoma and non-Hodgkin's lymphoma.Deoxycytidine analog that inhibits DNA synthesis. Metabolized to form gemcitabine triphosphate (dFdCTP) and gemcitabine diphosphate (dFdCDP). dFdCTD inhibits ribonucleotide reductase causing a reduction in cellular nucleotides. dFdCTP is incorporated in DNA resulting in DNA strand termination. It displays antitumor activity in vitro and in vivo.