产品详情
Product Name: (S)-(+)-Camptothecin
别名: | 喜树碱;4-乙基-4-羟基-1H-吡喃[3',4':6,7]氮茚[1,2]喹啉-3,14(4H,12H)-二酮 |
CAS号: | 7689-03-4 |
分子式: | C20H16N2O4 |
分子量: | 348.35 |
MDL号: | MFCD00081076 |
介绍: | 微溶于乙醇、氯仿,难溶于水。与酸不能生成稳定的盐,与氢氧化钠溶液加热反应可生成钠盐而溶于水。钠盐水溶液黄色澄明具蓝色荧光 |
用途: | 不可逆转地的结合到DNA拓扑异构酶I复合物上,影响细胞周期进程 |
熔点: | 259-263℃ |
特定比重: | 1.51 |
贮存: | 贮存温度2-8℃ |
生化和生理学机理: | Camptothecin (CPT), a cytotoxic quinoline alkaloid, is a potent DNA enzyme topoisomerase I (topo I) inhibitor with an IC50 and IC70 of 50 nM and 0.225 μM for breast cancer cell line MDA-MB-231. It has recently been undergoing phase I clinical trials. In 3D fluorescence spectra, Camptothecin presented 3 fluorescence peaks with excitation wavelengths lambdaex of 215, 255 and 365 nm, separately. Camptothecin shows high activity against various tumor cells. |