英文名称    Caspase-9    

中文名称    白介素1-β转化酶样凋亡蛋白酶6抗体    

别    名    Caspase-9 subunit p35; Apaf-3; APAF 3; APAF3; Apoptosis related cysteine peptidase; Apoptotic protease activating factor 3; Apoptotic protease MCH 6; Apoptotic protease MCH6; CASP 9; CASP9; Caspase 9; Caspase 9 apoptosis related cysteine protease; Caspase 9 precursor; Caspase 9c; Caspase9; Caspase9 subunit p10; ICE LAP6; ICE like apoptotic protease 6; RNCASP9; MCH 6; MCH6; OTTHUMP00000044594; CASP9_HUMAN.    

说 明 书    0.1ml  0.2ml      

研究领域    肿瘤  细胞生物  神经生物学  信号转导  细胞凋亡      

抗体来源    Rabbit    

克隆类型    Polyclonal    

交叉反应    Human, Mouse, Rat, Dog, Cow,     

产品应用    WB=1:100-500 ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 白介素1-β转化酶样凋亡蛋白酶6抗体（石蜡切片需做抗原修复） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.    

分 子 量    35/50kDa    

性    状    Lyophilized or Liquid    

浓    度    1mg/1ml    

免 疫 原    KLH conjugated synthetic peptide derived from human Caspase-9 subunit p35    

亚    型    IgG    

纯化方法    affinity purified by Protein A    

储 存 液    0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide    

保存条件    Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.    

白介素1-β转化酶样凋亡蛋白酶6抗体产品介绍    background:

Caspase 9 (also known as ICE like apoptotic protease 6 (ICE LAP6), apoptotic protease Mch6, and apoptotic protease activating factor 3 (Apaf3)) is a member of the peptidase family C14 that contains a CARD domain. This caspase is active as a heterotetramer and has been reported to have two isoforms. ProCaspase 9 has been reported to be approximately 47 kD. This caspase is present in the cytosol and, upon activation, translocates to the mitochondria. Caspase 9 is involved in the caspase activation cascade responsible for apoptosis execution and cleaves/activates Caspase 3 and Caspase 6. Caspase 9 is inhibited by the dominant negative isoform, BclXL, cIAP1, cIAP2, XIAP, and Livin. This caspase becomes activated when recruited to Apaf1/cytochrome c complex, and following cleavage by Apaf1, granzyme B, Caspase 3, possibly Caspase 8 and Caspase 10 into large p37 and small p10 subunits. Caspase 9 intereacts with BIRC7 and has been shown to cleave PARP and vimentin. 

Function:
Involved in the activation cascade of caspases responsible for apoptosis execution. Binding of caspase-9 to Apaf-1 leads to activation of the protease which then cleaves and activates caspase-3. Proteolytically cleaves poly(ADP-ribose) polymerase (PARP).
Isoform 2 lacks activity is an dominant-negative inhibitor of caspase-9.    

白介素1-β转化酶样凋亡蛋白酶6抗体

hz-7683R TReP132/RAPA  乳腺癌抗雌激素抵抗蛋白2抗体

hz-7684R ALS2CR8  肌萎缩侧索硬化2染色体区域候选蛋白8抗体

hz-7685R Corin  心脏特异性丝氨酸蛋白酶抗体

hz-7686R GPR55  蛋白偶联受体55抗体

hz-7687R LAP3  亮氨酸氨基肽酶3抗体

hz-7688R LMW Kininogen/Kininogen 1  低分子量生长促进因子抗体（激肽原1）

hz-7689R KCNMB1/Maxi Potassium channel beta  钙激活钾通道蛋白β1抗体

hz-7690R P2RX4  三磷酸腺苷门控阳离子通道蛋白抗体

hz-7691R ATP6IP2  ATP酶H+转运溶酶体辅助蛋白2抗体

hz-7692R Relaxin 1  松弛肽/松弛素抗体

hz-7693R Renalase  肾胺酶抗体

hz-7694R SLC12A3/NCCT  钠氯离子转运蛋白抗体

hz-7695R VNN1  血管非炎症分子1抗体

hz-7696R AXUD1  转化生长因子β诱导蛋白3抗体（半胱氨酸和丝氨酸富含核蛋白1）

hz-7697R BS69/Adenovirus 5 E1A binding protein  腺病毒5结合蛋白BS69抗体(骨形态发生蛋白受体相关分子1)

hz-7698R BTG3  高表达神经上皮蛋白BTG3抗体

hz-7699R BTG4  B细胞迁移基因4抗体

hz-4098R CARM1  蛋白精氨酸N甲基4抗体

hz-7700R BTN2A2  嗜乳脂蛋白亚家族2成员A2抗体

hz-1115R AMPK alpha 1/PRKAA1  腺苷单磷酸活化蛋白激酶α1抗体

hz-4002R phospho-AMPK alpha 1(Thr172)  磷酸化腺苷单磷酸活化蛋白激酶α1抗体

hz-7701R TP53TG3  p53靶蛋白3抗体

hz-7702R TP53TG5  p53靶蛋白5抗体

hz-7703R TSPYL5  睾丸特异性Y蛋白样5抗体

hz-7705R UBTD1  泛素结构域蛋白1抗体

hz-3025R phospho-AMPK alpha-1(Ser485+Ser491)  磷酸化腺苷单磷酸活化蛋白激酶α1抗体

hz-7706R VRK1  牛痘病毒相关激酶1抗体（丝氨酸/苏氨酸蛋白激酶VRK1）

hz-5551R phospho-AMPK alpha-1/PRKAA1(Thr198)  磷酸化腺苷单磷酸活化蛋白激酶α1抗体

hz-7707R ZBTB2  锌指蛋白437抗体

hz-2771R PRKAA2/AMPK alpha 2  腺苷单磷酸活化蛋白激酶α2抗体

hz-7708R ZNF415  锌指蛋白415抗体

hz-7709R Retinoic acid induced 17  维甲酸诱导蛋白17抗体