英文名称    CREB-1    

中文名称    环腺苷酸应答元件结合蛋白抗体    

别    名    Active transcription factor CREB; cAMP response element binding protein; cAMP responsive element binding protein 1; CREB 1; CREB1; MGC9284; Transactivator protein;CREB. 

说 明 书    0.1ml  0.2ml      

研究领域    信号转导      

抗体来源    Mouse    

克隆类型    Polyclonal    

交叉反应    Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Sheep,     

产品应用    WB=1:100-500 ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 环腺苷酸应答元件结合蛋白抗体（石蜡切片需做抗原修复） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.    

分 子 量    37kDa    

细胞定位    细胞核     

性    状    Lyophilized or Liquid    

浓    度    1mg/1ml    

免 疫 原    KLH conjugated synthetic peptide derived from human CREB-1    

亚    型    IgG    

纯化方法    affinity purified by Protein A    

储 存 液    0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide    

保存条件    Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. 

环腺苷酸应答元件结合蛋白抗体产品介绍    background:

Cyclic AMP Response Element Binding protein (CREB) is a basic / leucine zipper transcription factor that binds the cyclic AMP response element (CRE) and activates transcription in response to a variety of extracellular signals including neurotransmitters, hormones, membrane depolarization, and growth and neurotrophic factors. Activation of CREB is dependent upon the phosphorylation of serine 133. Phosphorylation occurs via p44 / 42 MAP kinase and p90RSK and also via p38 MAP kinase and MSK 1. Although CREB will bind DNA independent of its phosphorylation state, only the phosphorylated form is competent as a transcription factor. CREB binding protein (CBP), a transcriptional coactivator that directly interacts with CREB, binds to CREB in the region of serine 133. CREB appears to play an important role in learning and memory. CREB knock out mice show diminished learning ability.

Function:
Phosphorylation-dependent transcription factor that stimulates transcription upon binding to the DNA cAMP response element (CRE), a sequence present in many viral and cellular promoters. Transcription activation is enhanced by the TORC coactivators which act independently of Ser-133 phosphorylation. Involved in different cellular processes including the synchronization of circadian rhythmicity and the differentiation of adipose cells.    

环腺苷酸应答元件结合蛋白抗体

hz-1390R Cdc6  细胞分裂周期蛋白6抗体

hz-1448R Jagged1/CD339  Jagged1/CD339抗体

hz-5148R Cdc7  细胞分裂周期蛋白7抗体

hz-4244R Jagged 2  Notch配体Jagged 2蛋白抗体

hz-3525R SIGLEC14  唾液酸结合性免疫球蛋白样凝集素14抗体

hz-5246R phospho-Cdc6 (Ser54)  磷酸化细胞分裂周期蛋白6抗体

hz-2707R SIGLEC11  唾液酸结合性免疫球蛋白样凝集素11抗体

hz-1392R CDC34/UBC3  细胞周期调控因子34

hz-4295R CDC40  细胞分裂周期同源蛋白40抗体

hz-3813R CDC34B/UBC3B  泛素载体蛋白R2抗体

hz-5113R CDCA4  细胞分裂周期相关蛋白4抗体

hz-3555R CDC42  细胞分化周期CDC42蛋白抗体

hz-3369R Phospho-CDC42 (Ser71)  磷酸化细胞分化周期CDC42蛋白抗体

hz-4266R Cip4  细胞分化周期CDC42相互作用蛋白4抗体

hz-5726R BubR1  有丝分裂检验点蛋白BubR1抗体

hz-0542R CDK1/Cdc2  周期素依赖性激酶1抗体

hz-0757R CDK2  周期素依赖性激酶2抗体

hz-4297R CLIP1/CLIP170  细胞质连接蛋白1抗体

hz-3483R Phospho-CDK2 (Thr160)  磷酸化周期素依赖性激酶2抗体

hz-5277R Phospho-CDK2 (Thr14)  磷酸化周期素依赖性激酶2抗体

hz-1680R CDK3  周期素依赖性激酶3抗体

hz-0633R CDK4  周期素依赖性激酶4抗体

hz-4299R CNTROB  乳腺癌易感基因2相互作用蛋白抗体

hz-5727R HEC1  癌细胞高表达蛋白Hec1抗体

hz-0559R CDK5  周期素依赖性激酶5抗体

hz-5728R HURP/DAP5  肝癌上调蛋白抗体

hz-0568R CDK6  周期素依赖性激酶6抗体

hz-5286R phospho-CDK6 (Tyr13)  磷酸化周期素依赖性激酶6抗体

hz-5287R phospho-CDK6 (Tyr24)  磷酸化周期素依赖性激酶6抗体

hz-0569R CDK7  周期素依赖性激酶7抗体

hz-5729R LGALS3BP  可溶性半乳糖凝集素3结合蛋白抗体