3-异丁基-1-甲基黄嘌呤(IBMX)
99%
Product Name: 3-Isobutyl-1-methylxanthine
| 别名: | IBMX; 1-甲基-3-异丁基黄嘌呤; 3,7-二氢-1-甲基-3-(2-甲基丙基)-1H-嘌呤-2,6-二酮; 3-异丁基-1-甲基-2,6(1H,3H)-嘌呤二酮; 3-异丁基-1-甲基-2,6(1H,3H)-嘌呤二酮 |
| CAS号: | 28822-58-4 |
| 分子式: | C10H14N4O2 |
| 分子量: | 222.24 |
| EINECS编号: | 249-259-3 |
| MDL号: | MFCD00005584 |
3-异丁基-1-甲基黄嘌呤(IBMX)
| 介绍: | IBMX is a widely-used non-specific inhibitor of cyclic AMP (cAMP) and cyclic GMP (cGMP) phosphodiesterases (PDEs) (IC50 = 19, 50, 18, 13, 32, 7, and 50 μM for PDE1, PDE2, PDE3, PDE4, PDE5, PDE7, and PDE11, respectively). PDE8A, PDE8B, and PDE9 are insensitive to IBMX. By inhibiting PDEs, IBMX increases cellular cAMP and cGMP levels, activating cyclic-nucleotide-regulated protein kinases. Methylxanthines, including IBMX, caffeine, and theophylline, bind adenosine receptors,typically antagonizing the suppressive effects of natural agonists. |
| 用途: | cAMP 和 cGMP 磷酸二脂酶的非专一性抑制剂。IBMX抑制了磷酸二脂酶，cAMP的增加激活了PKA ，其结果是减少增殖，增加分化和诱发凋亡. IBMX抑制由苯肾上腺素诱导的色胺（来自于神经内分泌上皮细胞的减少粘液IC50: 1.3 μM）的减少 。也作为腺苷受体拮抗剂。 |
| 熔点: | 200-203℃ |
| 特定比重: | 1.2783-异丁基-1-甲基黄嘌呤(IBMX) |
| 贮存: | 储存温度-20°C |
