英文名称    CIP2A    

中文名称    蛋白磷酸酶PP2A癌抑制蛋白抗体    

别    名    p90 Autoantigen Cancerous Inhibitor of Protein Phosphatase 2A; CIP2A; FLJ12850; KIAA1524; MGC163436; p90; CIP2A/p90 Autoantigen.    

说 明 书    0.1ml  0.2ml      

研究领域    肿瘤  免疫学  肿瘤细胞生物标志物      

抗体来源    Rabbit    

克隆类型    Polyclonal    

交叉反应    Human, Mouse, Rat, Dog, Cow, Horse, Rabbit,     

产品应用    WB=1:100-500 ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 蛋白磷酸酶PP2A癌抑制蛋白抗体（石蜡切片需做抗原修复） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.    

分 子 量    100kDa    

细胞定位    细胞浆 细胞膜     

性    状    Lyophilized or Liquid    

浓    度    1mg/1ml    

免 疫 原    KLH conjugated synthetic peptide derived from human p90 Autoantigen    

亚    型    IgG    

纯化方法    affinity purified by Protein A    

储 存 液    0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide    

保存条件    Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.    

蛋白磷酸酶PP2A癌抑制蛋白抗体产品介绍    background:

Inhibition of protein phosphatase 2A (PP2A) activity has been identified as a prerequisite for the transformation of human cells. The protein, designated Cancerous Inhibitor of PP2A (CIP2A, p90 Autoantigen), interacts directly with the oncogenic transcription factor c-Myc, inhibits PP2A activity toward c-Myc serine 62 (S62), and thereby prevents c-Myc proteolytic degradation. In addition to its function in c-Myc stabilization, p90 Autoantigen promotes anchorage-independent cell growth and in vivo tumor formation. The oncogenic activity of p90 Autoantigen is demonstrated by transformation of human cells by overexpression of p90 Autoantigen. Importantly, p90 Autoantigen is overexpressed in two common human malignancies, head and neck squamous cell carcinoma (HNSCC) and colon cancer.

Subunit:
Interacts with MYC.    

蛋白磷酸酶PP2A癌抑制蛋白抗体

hz-6598R Cofilin  肌动蛋白结合蛋白CFL抗体

hz-6599R EphA5/Eph receptor A5  酪氨酸蛋白激酶A5受体抗体

hz-6600R HHEX/HMPH  同源盒蛋白PRH抗体

hz-5164R ETS1 associated protein II/EAPII  ETS1相关蛋白2抗体

hz-6601R TLR7  Toll样受体7抗体

hz-6603R HSD17B1/HSD17  羟类固醇脱氢酶17β抗体

hz-6604R BCNG1/HCN1  脑环核苷酸门控通道蛋白1抗体

hz-6605R BCAS3  乳腺癌相关蛋白3抗体

hz-6606R MRGX1/MRGPRC/SNSR  G蛋白偶联受体MRGX1抗体

hz-6607R TSPY1  睾丸特异定蛋白质编码Y1抗体

hz-6608R DDCT/DDT  D型多巴色素脱羧酶

hz-6609R Cyclophilin B  亲环蛋白PPIB抗体

hz-6610R BCAS2  乳腺癌相关蛋白2抗体

hz-6611R PLRP1/PNLIPRP1  胰脂肪酶相关蛋白1抗体

hz-6612R BMP15  骨形态发生蛋白15抗体

hz-6613R BCAT1  胞浆支链氨基酸酸转氨酶抗体

hz-6614R BMP5  骨形态发生蛋白5抗体

hz-6615R Hepatic lipase  肝脂酶抗体

hz-6617R GABA Transporter 1/GAT-1  γ氨基丁酸运载蛋白1抗体

hz-6618R PAPPA  妊娠相关血浆蛋白A抗体

hz-6619R PPT1  棕榈酰蛋白硫酯酶1抗体

hz-6620R CRHR2  促肾上腺皮质释放激素受体2抗体

hz-6621R CHX10  CHX10蛋白抗体

hz-6622R Glycophorin C/CD236  糖蛋白C抗体

hz-6623R Frizzled 2  Wnt信号受体FZD2蛋白抗体

hz-6624R IHH  HHG2抗体

hz-6625R Insig2  胰岛素诱导基因2抗体

hz-6626R MCHR/GPR24  G蛋白偶联受体24抗体

hz-6627R PSMC1/Proteasome 19S S4   26S蛋白酶调节亚型抗体

hz-6628R ZDHHC17/HIP14  NFκB激活蛋白205抗体

hz-6629R FANK1  HSD13蛋白抗体

hz-6630R Destrin 19/ADF  肌动蛋白解聚因子19抗体

hz-6631R Neurotensin/NTS  神经紧张素抗体