产品详情
英文名称 CEND1
中文名称 细胞周期通道和神经细胞分化蛋白1抗体
别 名 BM88; BM88 antigen; Cell cycle exit and neuronal differentiation 1; Cell cycle exit and neuronal differentiation protein 1; FLJ90066; MGC34326; CEND_HUMAN
说 明 书 0.2ml
研究领域 细胞生物 神经生物学 细胞周期蛋白 细胞分化 细胞类型标志物
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse, Rat, Horse,
产品应用 WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 细胞周期通道和神经细胞分化蛋白1抗体(石蜡切片需做抗原修复)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 15kDa
细胞定位 细胞膜
性 状 Lyophilized or Liquid
浓 度 1mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from human CEND1
亚 型 IgG
纯化方法 affinity purified by Protein A
储 存 液 Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
细胞周期通道和神经细胞分化蛋白1抗体产品介绍 background:
BM88 is a 149 amino acid protein that belongs to the CEND1 familly. Involved in neuroblastoma cell differentiation, BM88 is a single-pass type IV membrane protein that is neuron specific. It is suggested that BM88 forms a dimer of two identical polypeptides linked by disulfide bridges. BM88 has a central proline-rich region containing four PxxP motifs, which typically bind SRC homology-3 (SH3) domains, as well as a putative C-terminal transmembrane region, and several potential sites for N-glycosylation, myristoylation and phosphorylation. It is also suggested that a novel signaling mechanism exists by which BM88 interferes with calcium release from inositol 1,4,5-trisphosphate-sensitive stores and exerts anti-proliferative and anti-apoptotic functions. BM88 is an important molecular target for HDAC inhibition, and transcription of BM88 is induced by trichostatin-A.
Function:
CEND1 is a neuron-specific protein. The similar protein in pig enhances neuroblastoma cell differentiation in vitro and may be involved in neuronal differentiation in vivo. Multiple pseudogenes have been reported for this gene.
细胞周期通道和神经细胞分化蛋白1抗体
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hz-0370R-hzy7 Rabbit Anti-Goat IgM/Cy7 Cy7标记的兔抗羊IgM
hz-0370R-PE Rabbit Anti-Goat IgM/PE PE标记的兔抗羊IgM
hz-0370R-PE-hzy3 Rabbit Anti-Goat IgM/PE-Cy3 PE-Cy3标记的兔抗羊IgM
hz-0370R-PE-hzY5 Rabbit Anti-Goat IgM/PE-CY5 PE-CY5标记的兔抗羊IgM
hz-0370R-APhz Rabbit Anti-Goat IgM/APC APC标记的兔抗羊IgM
hz-0370R-AF350 Rabbit Anti-Goat IgM/Alexa Fluor 350 Alexa Fluor 350标记的兔抗羊IgM
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hz-0358R-PE-hzy5.5 Rabbit Anti-Guinea pig IgG/PE-Cy5.5 PE-Cy5.5标记的兔抗豚鼠IgG
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