英文名称    COPS8    

中文名称    信号转导蛋白亚基8抗体    

别    名    COP9 homolog; COP9 signalosome complex subunit 8; Cops8; CSN8; CSN8_HUMAN; hCOP9; JAB1 containing signalosome subunit 8; JAB1-containing signalosome subunit 8; SGN8; Signalosome subunit 8.    

说 明 书    0.1ml  0.2ml      

研究领域    细胞生物  发育生物学  染色质和核信号  信号转导  干细胞  激酶和磷酸酶      

抗体来源    Rabbit    

克隆类型    Polyclonal    

交叉反应    Human, Mouse, Rat, Rabbit,     

产品应用    WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:50-200 信号转导蛋白亚基8抗体（石蜡切片需做抗原修复） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.    

分 子 量    23kDa    

细胞定位    细胞核 细胞浆     

性    状    Lyophilized or Liquid    

浓    度    1mg/1ml    

免 疫 原    KLH conjugated synthetic peptide derived from human COPS8    

亚    型    IgG    

纯化方法    affinity purified by Protein A    

储 存 液    Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4    

保存条件    Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.    

信号转导蛋白亚基8抗体产品介绍    background:

The protein encoded by this gene is one of the eight subunits of COP9 signalosome, a highly conserved protein complex that functions as an important regulator in multiple signaling pathways. The structure and function of COP9 signalosome is similar to that of the 19S regulatory particle of 26S proteasome. COP9 signalosome has been shown to interact with SCF-type E3 ubiquitin ligases and act as a positive regulator of E3 ubiquitin ligases. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008].

Function:
Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively.    

信号转导蛋白亚基8抗体

hz-7849R TBCD/Beta tubulin cofactor D  微管蛋白β辅助因子D抗体

hz-7850R MPS1/TTK  单极纺锤体蛋白激酶1抗体

hz-7851R katanin p80  剑蛋白p80抗体

hz-7852R ZWINT  着丝粒ZW10相互作用蛋白1抗体

hz-7853R ABCA9  三磷酸腺苷结合盒转运蛋白9抗体

hz-7854R AHI1  白血病相关蛋白AHI1抗体

hz-7855R AICDA  活化诱导胞嘧啶核苷脱氨酶抗体

hz-7856R ALOXE3  表皮型脂氧合酶3抗体（鱼鳞病相关蛋白）

hz-7857R ALPK3  α蛋白激酶3抗体（心肌）

hz-7858R CEND1  细胞周期通道和神经细胞分化蛋白1抗体

hz-7859R DHRS9  短链脱氢酶/还原酶家族9抗体

hz-7860R DLL3  Notch信号通路Delta样配体3抗体

hz-7861R hzE1  减数分裂内切酶hzE1抗体

hz-7862R FAM3C/ILEI  上皮分泌型FAM3C蛋白抗体

hz-7863R FSTL5  卵泡抑素相关蛋白5抗体

hz-7864R Flightless 1  凝溶胶蛋白家族Fli-1抗体

hz-7865R GPSM1  G蛋白信号调节蛋白1抗体

hz-7866R Intra Acrosomal Protein/SP10  精子顶端体蛋白10抗体

hz-7868R KLHL8  Kelch样蛋白8抗体

hz-7867R Iroquois homeobox protein 3  Irx3蛋白抗体

hz-7869R LHX6  转录因子LHX6抗体

hz-7870R MRP8+MRP14  多药耐药相关蛋白8/9/14抗体

hz-7871R NEU4  神经氨酸酶4抗体

hz-7872R PPHLN1  脉周蛋白1抗体（胃癌抗原蛋白Ga50）

hz-7873R S100 alpha 2  S100A2抗体

hz-7874R SART1  T淋巴细胞识别的鳞状细胞癌抗原抗体

hz-7875R SCEL  SCEL蛋白抗体

hz-7876R SPAG8  精子相关抗原8抗体

hz-7877R NEDD4  神经前体细胞发育下调蛋白4抗体

hz-7878R STAM  信号转导衔接蛋白1抗体

hz-7879R SUPT16H/CDC68  染色体特异性转录延伸因子抗体

hz-7880R MEGF5/Slit3  复合型表皮生长因子样结构域蛋白5抗体

hz-7881R TRIM29/ATDC  共济失调毛细血管扩张症D相关蛋白抗体

hz-7882R UBE2V1/UEV1A  泛素结合酶E2变异体1抗体

hz-7883R VHLH/Von Hippel Lindau  脑视网膜血管瘤G7蛋白抗体（逢希伯-林道氏病）

hz-7884R Cyclin B3  周期素B3抗体