英文名称    COPS7A    

中文名称    信号转导蛋白亚基7A抗体    

别    名    DERP10; COP9 signalosome complex subunit 7a; CSN7A; Dermal papilla derived protein 10; JAB1 containing signalosome subunit 7a; SGN7a; Signalosome subunit 7a; CSN7A_HUMAN.    

说 明 书    0.2ml      

研究领域    细胞生物  免疫学      

抗体来源    Rabbit    

克隆类型    Polyclonal    

交叉反应    Human, Mouse, Rat, Dog, Cow, Horse, Rabbit, Sheep,     

产品应用    WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:50-200 （石蜡切片需做抗原修复）信号转导蛋白亚基7A抗体 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.    

分 子 量    30kDa    

细胞定位    细胞核 细胞浆     

性    状    Lyophilized or Liquid    

浓    度    1mg/1ml    

免 疫 原    KLH conjugated synthetic peptide derived from human COPS7A    

亚    型    IgG    

纯化方法    affinity purified by Protein A    

储 存 液    Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4    

保存条件    Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.    

信号转导蛋白亚基7A抗体产品介绍    background:

COPS7A is a component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2.

Function:
Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, JUN, I-kappa-B-alpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively.     

信号转导蛋白亚基7A抗体

hz-7955R TPTE  肿瘤/睾丸抗原44抗体

hz-7956R ALDH16A1  乙醛脱氢酶16家庭A1抗体

hz-7957R ALG11  天门冬酰胺连接糖基化11抗体

hz-7958R ALS2CR4  肌萎缩侧索硬化症相关蛋白4抗体

hz-7959R AMIGO3  粘附分子IgG样结构域蛋白3抗体

hz-7960R AMN1  细胞核重定位及纺锤体检查点蛋白AMN1抗体

hz-7961R ANKRD11  锚蛋白重复结构域蛋白11抗体

hz-7962R ANKRD12  锚蛋白重复结构域蛋白12抗体

hz-7963R ANKRD13A  锚蛋白重复结构域蛋白13A抗体

hz-7964R ANKRD9  锚蛋白重复结构域蛋白9抗体

hz-7965R APM2  脂肪特定转录因子2抗体

hz-7966R ANKS1A  锚蛋白重复及SAM结构域蛋白1A抗体

hz-7967R APOL3  载脂蛋白L3抗体

hz-7969R ARMC3 (Cancer/testis antigen 81)  肿瘤/睾丸抗原81抗体

hz-7970R ARS2  砷酸盐耐药蛋白ARS2抗体

hz-7971R ARSA  芳香基硫酸酯酶1抗体

hz-7972R ASNA1  砷酸盐转运三磷酸腺苷酶抗体

hz-7973R ATE1  精氨酸tRNA的蛋白转移酶1抗体

hz-7974R ATX2  脊髓小脑共济失调2型蛋白抗体

hz-7975R ATXN7L1  共济失调蛋白7样1抗体

hz-7976R ATXN7L2  共济失调蛋白7样2抗体

hz-7977R BCNP  B淋巴细胞新型蛋白1抗体

hz-7978R BEX4  脑表达X连锁蛋白4抗体

hz-7940R ABCA5  三磷酸腺苷结合盒转运蛋白A亚基5抗体

hz-7979R BTBD7  BTB/POZ结构域蛋白7抗体

hz-7980R GUSB/beta glucuronidase  β葡萄糖醛酸苷酶抗体

hz-7981R CA13  碳酸酐酶

hz-7982R HOXC9  同源盒蛋白HOXC9抗体

hz-7983R CA6  碳酸酐酶6抗体

hz-7984R CA7  碳酸酐酶7抗体

hz-7985R CCBE1  胶原蛋白和钙结合表皮生长因子结构域1抗体

hz-7986R CCDC102B  卷曲螺旋结构域蛋白102B抗体

hz-7987R CCDC16/ZNF83  卷曲螺旋结构域蛋白16抗体

hz-7988R CCDC21  卷曲螺旋结构域蛋白21抗体