产品详情
英文名称 CTDSP1
中文名称 羧基端小结构域磷酸酶1抗体
别 名 Carboxy terminal domain RNA polymerase II polypeptide A small phosphatase 1; Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1; CTD (carboxy terminal domain RNA polymerase II polypeptide A) small phosphatase 1; CTDS1_HUMAN; CTDSP1; NIF3; NLI IF; NLI interacting factor 3; NLI-IF; NLI-interacting factor 3; NLIIF; Nuclear LIM interactor interacting factor 3; Nuclear LIM interactor-interacting factor 3; SCP1; Small C-terminal domain phosphatase 1; Small CTD phosphatase 1.
说 明 书 0.1ml 0.2ml
研究领域 细胞生物 神经生物学 信号转导 表观遗传学
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse, Rat, Dog, Cow, Horse, Sheep,
产品应用 WB=1:100-500 ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 羧基端小结构域磷酸酶1抗体（石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 29kDa
细胞定位 细胞核
性 状 Lyophilized or Liquid
浓 度 1mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from human CTDSP1
亚 型 IgG
纯化方法 affinity purified by Protein A
储 存 液 Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
羧基端小结构域磷酸酶1抗体产品介绍 background:
This gene encodes a member of the small C-terminal domain phosphatase (SCP) family of nuclear phosphatases. These proteins play a role in transcriptional regulation through specific dephosphorylation of phosphoserine 5 within tandem heptapeptide repeats of the C-terminal domain of RNA polymerase II. The encoded protein plays a role in neuronal gene silencing in non-neuronal cells, and may also inhibit osteoblast differentiation. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Oct 2011]
Function:
Preferentially catalyzes the dephosphorylation of 'Ser-5' within the tandem 7 residues repeats in the C-terminal domain (CTD) of the largest RNA polymerase II subunit POLR2A. Negatively regulates RNA polymerase II transcription, possibly by controlling the transition from initiation/capping to processive transcript elongation. Recruited by REST to neuronal genes that contain RE-1 elements, leading to neuronal gene silencing in non-neuronal cells.
羧基端小结构域磷酸酶1抗体
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