英文名称    Dengue virus envelope glycoprotein E    

中文名称    登革热病毒包膜糖蛋白E抗体    

别    名    Dengue virus; DV1_gp1; Genome polyprotein; envelope glycoprotein (Dengue virus type-2); Dengue virus envelope glycoprotein E; Polyprotein; DEN polyprotein.    

说 明 书    0.1ml  0.2ml      

研究领域    细菌及病毒      

抗体来源    Rabbit    

克隆类型    Polyclonal    

交叉反应    Dengue virus type-2    

产品应用    WB=1:100-500 ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 登革热病毒包膜糖蛋白E抗体（石蜡切片需做抗原修复） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.    

分 子 量    54kDa    

细胞定位    细胞浆 细胞膜 分泌型蛋白     

性    状    Lyophilized or Liquid    

浓    度    1mg/1ml    

免 疫 原    KLH conjugated synthetic peptide derived from Dengue virus type-2 envelope glycoprotein E    

亚    型    IgG    

纯化方法    affinity purified by Protein A    

储 存 液    0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide    

保存条件    Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.    

登革热病毒包膜糖蛋白E抗体产品介绍    background:

Envelope protein E binding to host cell surface receptor is followed by virus internalization through clathrin-mediated endocytosis. Envelope protein E is subsequently involved in membrane fusion between virion and host late endosomes. Synthesized as a homodimer with prM which acts as a chaperone for envelope protein E. After cleavage of prM, envelope protein E dissociate from small envelope protein M and homodimerizes.

Function:
prM acts as a chaperone for envelope protein E during intracellular virion assembly by masking and inactivating envelope protein E fusion peptide. prM is matured in the last step of virion assembly, presumably to avoid catastrophic activation of the viral fusion peptide induced by the acidic pH of the trans-Golgi network. After cleavage by host furin, the pr peptide is released in the extracellular medium and small envelope protein M and envelope protein E homodimers are dissociated (By similarity). 
Envelope protein E binding to host cell surface receptor is followed by virus internalization through clathrin-mediated endocytosis. Envelope protein E is subsequently involved in membrane fusion between virion and host late endosomes. Synthesized as a homodimer with prM which acts as a chaperone for envelope protein E. After cleavage of prM, envelope protein E dissociate from small envelope protein M and homodimerizes (By similarity). 
Non-structural protein 1 is involved in virus replication and regulation of the innate immune response. Soluble and membrane-associated NS1 may activate human complement and induce host vascular leakage. This effect might explain the clinical manifestations of dengue hemorrhagic fever and dengue shock syndrome (By similarity).     

登革热病毒包膜糖蛋白E抗体

hz-4070R SNX25  分拣微管连接蛋白抗体

hz-0007R ADM/AM/Adrenomedullin  肾上腺髓质素抗体

hz-0995R ADM (ProAM-N20)  肾上腺髓质素抗体(N端20肽)

hz-0090R ADM R  肾上腺髓质素受体抗体

hz-5147R C CBL  原癌基因CBL2抗体

hz-5328R 5HT3C/5HT3E   5-羟色胺受体3C抗体

hz-4071R phospho-C CBL(Tyr674)  磷酸化原癌基因CBL2抗体

hz-0039R ADNP/NAP  活性依赖的神经保护肽抗体

hz-4072R Cphospho-C CBL(Tyr700)  磷酸化原癌基因CBL2抗体

hz-1225R ADORA3  腺苷受体A3抗体

hz-2640R ADO  2-氨基乙硫醇双加氧酶抗体

hz-2203R Integrin Alpha V  整合素αV抗体

hz-5149R CPI17 alpha  蛋白磷酸激酶PKC/CPI-17抗体

hz-4073R phospho-CPI17 alpha (Thr38)   磷酸化蛋白磷酸激酶PKC/CPI-17抗体

hz-1062R ADRA2  ADRA2肾上腺素能受体2抗体

hz-0498R ADRB1  肾上腺素能受体β1抗体

hz-5150R APE/Girdin  肌动蛋白结合蛋白Girdin抗体

hz-5835R Drebrin  脑发育调节蛋白抗体

hz-5152R DAG1  肌萎缩相关蛋白DAG1抗体

hz-0947R ADRB2  肾上腺素能受体β2抗体（β2-AR ）

hz-3002R phospho-ADRB2(Ser346)  磷酸化肾上腺素能受体β2抗体

hz-5211R phospho-ADRB2 (Ser261)  磷酸化肾上腺素能受体β2抗体

hz-4075R phospho-DAG1 (Tyr892)  磷酸化肌萎缩相关蛋白DAG1抗体

hz-6026R SynCAM  细胞粘附分子1抗体

hz-6027R CADM3/IGSF4B  细胞粘附分子3抗体

hz-5995R CAMTA1  钙调蛋白结合转录激活因子1抗体

hz-5996R CDC4/FBW7/SEL10  肿瘤抑制因子FBW7抗体

hz-5997R CADM 4  细胞粘附分子4抗体

hz-5998R DAB2IP  Dab2相互作用蛋白抗体

hz-5999R DAB2  信号转导功能磷蛋白DAB2抗体

hz-1063R ADRB3/beta 3 Adrenergic Receptor  β3肾上腺素能受体抗体

hz-6000R DACH1  细胞命运决定因子DACH1抗体

hz-6001R DRG1  GTP发育调控结合蛋白1抗体

hz-6002R DNAJB4/HSP40 homolog  热休克蛋白家族40抗体