英文名称    DOK3    

中文名称    对接蛋白3抗体    

别    名    Docking protein 3; DOK 3; DOK Like Protein; DOKL Pending; Downstream of tyrosine kinase 3; p62 DOK Like Protein; DOK3_HUMAN.    

说 明 书    0.2ml      

研究领域    肿瘤  信号转导  转录调节因子  激酶和磷酸酶  G蛋白信号      

抗体来源    Rabbit    

克隆类型    Polyclonal    

交叉反应    Human, Mouse, Rat, Cow,     

产品应用    WB=1:100-500 ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 对接蛋白3抗体（石蜡切片需做抗原修复） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.    

分 子 量    53kDa    

细胞定位    细胞浆 细胞膜     

性    状    Lyophilized or Liquid    

浓    度    1mg/1ml    

免 疫 原    KLH conjugated synthetic peptide derived from human DOK3    

亚    型    IgG    

纯化方法    affinity purified by Protein A    

储 存 液    Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4    

保存条件    Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.    

对接蛋白3抗体产品介绍    background:

DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK3 is a negative regulator of JNK signaling in B-cells through interaction with INPP5D/SHIP1. May modulate Abl functionDOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK3 is a negative regulator of JNK signaling in B-cells through interaction with INPP5D/SHIP1. May modulate Abl function. There are 4 isoforms generated by alternative splicing.

Function:
DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK3 is a negative regulator of JNK signaling in B-cells through interaction with

Subunit:
On tyrosine phosphorylation, interacts with CSK and INPP5D/SHIP1 via their SH2 domains. Both Tyr-381 and Tyr-398 are required for interaction with INPP5D. Only Tyr-381 is required for interaction with CSK. Binds ABL1 through the PTB domain and in a kinase-dependent manner. Does not interact with RasGAP (By similarity).

Subcellular Location:
Cytoplasm (By similarity). Cell membrane; Peripheral membrane protein; Cytoplasmic side (By similarity).

Tissue Specificity:
Expressed in spleen.

Post-translational modifications:
Constitutively tyrosine-phosphorylated (By similarity).
On IL2 stimulation, phosphorylated on C-terminal tyrosine residues possibly by Src kinases. Can also be phosphorylated by ABL1 kinase (By similarity).     

对接蛋白3抗体

hz-4276R ELAC2  遗传性前列腺癌蛋白2抗体

hz-0646R CD34  CD34抗体

hz-2038R CD34  CD34抗体

hz-0979R CD38  CD38抗体

hz-0980R CD38  CD38抗体

hz-4277R ENPP7  碱性鞘磷脂酶7抗体

hz-2596R CR1/CD35  Ⅰ型补体受体抗体（C3b/C4b受体抗体）

hz-4274R DBC2  乳腺癌基因删除蛋白2抗体

hz-4278R FAT/CDHF7/FAT1  钙粘蛋白家族成员7抗体

hz-1100R CD36/PAS-4  CD36抗体

hz-4279R GAS7/Growth Arrest Specific Protein 7  生长休止特定蛋白7抗体

hz-4275R EB3  微管相关蛋白EB家族3抗体

hz-0766R CD4  CD4抗体

hz-0647R CD4  CD4抗体

hz-1520R CD7  CD7抗体

hz-0648R CD8  CD8抗体

hz-4914R CD8B  CD8β链（CD8-β）抗体

hz-4602R CD8/CD8-β  CD8抗体

hz-2489R CD9/MRP-1  CD9蛋白抗体

hz-5711R CCDC106  卷曲螺旋结构域蛋白106抗体

hz-2929R CD40/TNFRSF5  肿瘤坏死因子受体超家族成员5抗体

hz-1286R CD40L  CD40L抗体

hz-2347R GP1B/CD42b  血小板糖蛋白GPIb抗体

hz-2636R Integrin alpha 2b/CD41  血小板膜糖蛋白ⅡbⅢa抗体

hz-2496R CD43/SPN  CD43抗体

hz-0521R CD44/HCAM/PGP1  CD44抗体

hz-4281R HAUSP/USP7  疱疹病毒相关泛素特异性蛋白酶7抗体

hz-2783R CD44v4  CD44V4抗体

hz-2782R CD44v5  CD44V5抗体

hz-2507R CD44v6  CD44V6抗体

hz-2779R CD44v7  CD44V7抗体

hz-2780R CD44v10  CD44V10抗体