英文名称    DR6    

中文名称    肿瘤细胞调亡素/肿瘤坏死因子受体死亡受体6抗体    

别    名    TNFRSF 21; BM 018; BM018; CD358; Death receptor 6; DR 6; MGC31965; TNFR related death receptor 6; TNFRSF21; TNFRSF21 protein; TNR21_HUMAN; Tumor necrosis factor receptor superfamily member 21; Tumor necrosis factor receptor superfamily member 21 precursor.    

说 明 书    0.1ml  0.2ml      

研究领域    细胞生物  细胞凋亡      

抗体来源    Rabbit    

克隆类型    Polyclonal    

交叉反应    Human, Mouse, Rat, Chicken, Dog, Cow, Horse, Rabbit,     

产品应用    WB=1:100-500 ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 Flow-Cyt=1:100-500 ICC=1:100-500 IF=1:100-500 肿瘤细胞调亡素/肿瘤坏死因子受体死亡受体6抗体（石蜡切片需做抗原修复） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.    

分 子 量    52/68kDa    

细胞定位    细胞膜     

性    状    Lyophilized or Liquid    

浓    度    1mg/1ml    

免 疫 原    KLH conjugated synthetic peptide derived from human DR6/CD358    

亚    型    IgG    

纯化方法    affinity purified by Protein A    

储 存 液    Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4    

保存条件    Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.    

肿瘤细胞调亡素/肿瘤坏死因子受体死亡受体6抗体产品介绍    background:

May activate NF-kappa-B and promote apoptosis. May activate JNK and be involved in T-cell differentiation. Required for both normal cell body death and axonal pruning. Trophic-factor deprivation triggers the cleavage of surface APP by beta-secretase to release sAPP-beta which is further cleaved to release an N-terminal fragment of APP (N-APP). N-APP binds TNFRSF21 triggering caspase activation and degeneration of both neuronal cell bodies (via caspase-3) and axons (via caspase-6).
Tissue specificity: Highly expressed in heart, brain, placenta, pancreas, lymph node, thymus and prostate. Detected at lower levels in lung, skeletal muscle, kidney, testis, uterus, small intestine, colon, spleen, bone marrow and fetal liver. Very low levels were found in adult liver and peripheral blood leukocytes.

Function:
May activate NF-kappa-B and promote apoptosis. May activate JNK and be involved in T-cell differentiation. Required for both normal cell body death and axonal pruning. Trophic-factor deprivation triggers the cleavage of surface APP by beta-secretase to release sAPP-beta which is further cleaved to release an N-terminal fragment of APP (N-APP). N-APP binds TNFRSF21 triggering caspase activation and degeneration of both neuronal cell bodies (via caspase-3) and axons (via caspase-6). 

Subunit:
Associates with TRADD. Interacts with N-APP (By similarity).

Subcellular Location:
Membrane; Single-pass type I membrane protein (Probable). 

Tissue Specificity:
Highly expressed in heart, brain, placenta, pancreas, lymph node, thymus and prostate. Detected at lower levels in lung, skeletal muscle, kidney, testis, uterus, small intestine, colon, spleen, bone marrow and fetal liver. Very low levels were found in adult liver and peripheral blood leukocytes. 

Similarity:
Contains 1 death domain. 
Contains 4 TNFR-Cys repeats.     

肿瘤细胞调亡素/肿瘤坏死因子受体死亡受体6抗体

hz-5177R phospho-GADD153 (Ser30)  磷酸化GADD153抗体

hz-5958R AF 4 protein  原癌基因AF4蛋白抗体

hz-0017M Galanin  神经节肽抗体

hz-5960R B MyB  转录因子MYB相关蛋白B抗体

hz-0721R Galectin 3  半乳糖凝集素3抗体

hz-3983R Galactose kinase/GALK1  半乳糖激酶1抗体

hz-1699R Galectin 9  半乳糖凝集素9抗体

hz-3984R GALT  磷酸半乳糖尿苷酸转移酶1抗体

hz-0154R GAP43  神经生长相关蛋白43

hz-5962R BORIS/CT27  肿瘤/睾丸抗原27抗体（高迁移率族蛋白）

hz-1641R phospho-GAP43(Ser41)  磷酸化神经生长相关蛋白43抗体

hz-5963R CDCA7L  细胞分裂周期相关蛋白JPO2抗体

hz-5964R ETS2  癌基因ETS2抗体

hz-0755R GAPDH  3-磷酸甘油醛脱氢酶（兔来源免疫组化用抗体）

hz-0835R GAPDH  3-磷酸甘油醛脱氢酶（兔来源免疫组化用抗体）

hz-5965R ETV7  转录因子ETV7抗体

hz-5966R LMO4  乳腺肿瘤自身抗原LMO4抗体

hz-0459R GAPDH  3-磷酸甘油醛脱氢酶（兔来源免疫组化用抗体）

hz-3795R GCDGP15/SABP  囊性组织液体蛋白15抗体

hz-1429R GNAI3  抑制型G蛋白α3抗体

hz-5967R NFhz5/IRF4/MUM1  淋巴细胞特异性干扰素调节因子抗体

hz-0341R CXCR3/CD183  细胞表面趋化因子受体3抗体

hz-2209R CXCR3/CD183  细胞表面趋化因子受体3抗体

hz-3598R CXCR5/CD185  细胞表面趋化因子受体5抗体

hz-5968R NARG2  谷氨酸受体调节蛋白2抗体

hz-5920R PATZ1  转录调节因子MAZR抗体

hz-1189R Gastrin  胃泌素/蛙皮素抗体

hz-1777R Gastrin receptor/GASR  促胃泌素受体抗体

hz-3872R GATA-1  珠蛋白转录因子1抗体

hz-5369R phospho-GATA1(ser142)  磷酸化珠蛋白转录因子1抗体

hz-5370R phospho-GATA1(ser310)  磷酸化珠蛋白转录因子1抗体

hz-6616R GATA-2  GATA结合蛋白2抗体

hz-1452R GATA-3  GATA结合蛋白3抗体

hz-1778R GATA-4  GATA结合蛋白4抗体