英文名称    DNAI1 + 2    

中文名称    轴丝中链动力蛋白抗体    

别    名    DNAI1; DNAI1 / 2; DNAI1/2; DNAI 1/2; DNAI 1 + 2; Axonemal dynein intermediate chain 1; Axonemal dynein intermediate chain 2; CILD 1; CILD1; DNAI 1; DNAI 2; DNAI1_HUMAN; Dynein axonemal intermediate chain 1; Dynein axonemal intermediate polypeptide 1; Dynein axonemal intermediate polypeptide 2; Dynein intermediate chain 1 axonemal; Dynein intermediate chain 1 cytosolic; Dynein intermediate chain 1, axonemal; Dynein intermediate chain 2 axonemal; Dynein intermediate chain 2 cytosolic; Dynein intermediate chain DNAI1; ICS; MGC26204; PCD.    

说 明 书    0.2ml      

研究领域    神经生物学  信号转导  细胞粘附分子  细胞骨架      

抗体来源    Rabbit    

克隆类型    Polyclonal    

交叉反应    Human, Mouse, Rat, Dog, Cow, Horse, Rabbit, Sheep,     

产品应用    WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 轴丝中链动力蛋白抗体（石蜡切片需做抗原修复） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.    

分 子 量    79kDa    

细胞定位    细胞浆     

性    状    Lyophilized or Liquid    

浓    度    1mg/1ml    

免 疫 原    KLH conjugated synthetic peptide derived from human DNAI1/2    

亚    型    IgG    

纯化方法    affinity purified by Protein A    

储 存 液    Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4    

保存条件    Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.    

轴丝中链动力蛋白抗体产品介绍    background:

The inner- and outer-arm dyneins, which bridge between the doublet microtubules in axonemes, are the force-generating proteins responsible for the sliding movement in axonemes. The intermediate and light chains, thought to form the base of the dynein arm, help mediate attachment and may also participate in regulating dynein activity. This gene encodes an intermediate chain dynein, belonging to the large family of motor proteins. Mutations in this gene result in abnormal ciliary ultrastructure and function associated with primary ciliary dyskinesia (PCD) and Kartagener syndrome. [provided by RefSeq, Jul 2008].

Function:
Part of the dynein complex of respiratory cilia.

Subunit:
Consists of at least two heavy chains and a number of intermediate and light chains. 

Subcellular Location:
Cytoplasm, cytoskeleton, cilium axoneme. 

DISEASE:
Defects in DNAI1 are the cause of primary ciliary dyskinesia type 1 (CILD1) [MIM:244400]. CILD1 is an autosomal recessive disorder characterized by axonemal abnormalities of motile cilia. Respiratory infections leading to chronic inflammation and bronchiectasis are recurrent, due to defects in the respiratory cilia; reduced fertility is often observed in male patients due to abnormalities of sperm tails. Half of the patients exhibit situs inversus, due to dysfunction of monocilia at the embryonic node and randomization of left-right body asymmetry. Primary ciliary dyskinesia associated with situs inversus is referred to as Kartagener syndrome. 
Defects in DNAI1 are the cause of Kartagener syndrome (KTGS) [MIM:244400]. KTGS is an autosomal recessive disorder characterized by the association of primary ciliary dyskinesia with situs inversus. Clinical features include recurrent respiratory infections, bronchiectasis, infertility, and lateral transposition of the viscera of the thorax and abdomen. The situs inversus is most often total, although it can be partial in some cases (isolated dextrocardia or isolated transposition of abdominal viscera). 

Similarity:
Belongs to the dynein intermediate chain family. 
Contains 5 WD repeats.    

轴丝中链动力蛋白抗体

hz-0326G-hzy7 Goat Anti-Bovine IgG/Cy7  Cy7标记的羊抗牛IgG

hz-0326G-PE Goat Anti-Bovine IgG/PE  PE标记的羊抗牛IgG

hz-0326G-PE-hzy3 Goat Anti-Bovine IgG/PE-Cy3  PE-Cy3标记的羊抗牛IgG

hz-0326G-PE-hzY5 Goat Anti-Bovine IgG/PE-CY5  PE-CY5标记的羊抗牛IgG

hz-0326G-APhz Goat Anti-Bovine IgG/APC  APC标记的羊抗牛IgG

hz-0326G-AF350 Goat Anti-Bovine IgG/Alexa Fluor 350  Alexa Fluor 350标记的羊抗牛IgG

hz-0326G-AF488 Goat Anti-Bovine IgG/Alexa Fluor 488  Alexa Fluor 488标记的羊抗牛IgG

hz-0326G-AF555 Goat Anti-Bovine IgG/Alexa Fluor 555  Alexa Fluor 555标记的羊抗牛IgG

hz-0326G-AF647 Goat Anti-Bovine IgG/Alexa Fluor 647  Alexa Fluor 647标记的羊抗牛IgG

hz-0326G-PE-hzy5.5 Goat Anti-Bovine IgG/PE-Cy5.5  PE-Cy5.5标记的羊抗牛IgG

hz-0326G-PE-hzy7 Goat Anti-Bovine IgG/PE-Cy7  PE-Cy7标记的羊抗牛IgG

hz-0326G-RBIThz Goat Anti-Bovine IgG/RBITC  罗丹明标记的羊抗牛IgG

hz-0326G-FIThz Goat Anti-Bovine IgG/FITC  FITC标记的羊抗牛IgG

hz-0326G-Gold Goat Anti-Bovine IgG/Gold  胶体金标记的羊抗牛IgG

hz-0326G-AP Goat Anti-Bovine IgG/AP  碱性磷酸酶（AP）标记的羊抗牛IgG

hz-0326G-hzy5.5 Goat Anti-Bovine IgG/Cy5.5  Cy5.5标记的羊抗牛IgG

hz-0326G-HRP Goat Anti-Bovine IgG/HRP  辣根过氧化物酶标记的羊抗牛IgG

hz-0326G-Bio Goat Anti-Bovine IgG/Bio  生物素标记的羊抗牛IgG

hz-0296G-Bio Goat Anti-Mouse IgG/Bio  生物素标记的羊抗小鼠IgG

hz-0296G-hzy3 Goat Anti-Mouse IgG/Cy3  Cy3标记的羊抗小鼠IgG

hz-0296G-hzy5 Goat Anti-Mouse IgG/Cy5  Cy5标记的羊抗小鼠IgG

hz-0296G-hzy5.5 Goat Anti-Mouse IgG/Cy5.5  Cy5.5标记的羊抗小鼠IgG

hz-0296G-hzy7 Goat Anti-Mouse IgG/Cy7  Cy7标记的羊抗小鼠IgG

hz-0296G-PE Goat Anti-Mouse IgG/PE  PE标记的羊抗小鼠IgG

hz-0296G-PE-hzy3 Goat Anti-Mouse IgG/PE-Cy3  PE-Cy3标记的羊抗小鼠IgG

hz-0296G-PE-hzY5 Goat Anti-Mouse IgG/PE-CY5  PE-CY5标记的羊抗小鼠IgG

hz-0296G-APhz Goat Anti-Mouse IgG/APC  APC标记的羊抗小鼠IgG

hz-0296G-AF350 Goat Anti-Mouse IgG/Alexa Fluor 350  Alexa Fluor 350标记的羊抗小鼠IgG

hz-0296G-AF488 Goat Anti-Mouse IgG/Alexa Fluor 488  Alexa Fluor 488标记的羊抗小鼠IgG

hz-0296G-AF555 Goat Anti-Mouse IgG/Alexa Fluor 555  Alexa Fluor 555标记的羊抗小鼠IgG

hz-0296G-AF647 Goat Anti-Mouse IgG/Alexa Fluor 647  Alexa Fluor 647标记的羊抗小鼠IgG

hz-0296G-PE-hzy5.5 Goat Anti-Mouse IgG/PE-Cy5.5  PE-Cy5.5标记的羊抗小鼠IgG

hz-0296G-PE-hzy7 Goat Anti-Mouse IgG/PE-Cy7  PE-Cy7标记的羊抗小鼠IgG

hz-0296G-AP Goat Anti-Mouse IgG/AP  碱性磷酸酶（AP）标记的羊抗小鼠IgG