英文名称    DAZL    

中文名称    生殖细胞发育相关蛋白DAZL抗体    

别    名    DAZ homolog; DAZ like autosomal; DAZ-like autosomal; deleted in azoospermia-like; DAZH; DAZL 1; DAZL; DAZL_HUMAN; DAZL1; DAZLA; Deleted in azoospermia like 1; Deleted in azoospermia like; Deleted in azoospermia like autosomal; Deleted in azoospermia-like 1; Deleted in azoospermia-like; Germline specific RNA binding protein; MGC26406; Spermatogenesis gene on the Y like autosomal; SPGY like autosomal; SPGY-like-autosomal; SPGYLA; Tpx2.    

说 明 书    0.2ml      

研究领域    发育生物学  干细胞  转录调节因子  表观遗传学      

抗体来源    Rabbit    

克隆类型    Polyclonal    

交叉反应    Human, Mouse, Dog, Pig, Cow, Horse, Rabbit, Sheep,     

产品应用    WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 生殖细胞发育相关蛋白DAZL抗体（石蜡切片需做抗原修复） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.    

分 子 量    33kDa    

细胞定位    细胞核 细胞浆     

性    状    Lyophilized or Liquid    

浓    度    1mg/1ml    

免 疫 原    KLH conjugated synthetic peptide derived from human DAZL (51-130aa)    

亚    型    IgG    

纯化方法    affinity purified by Protein A    

储 存 液    Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4    

保存条件    Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.    

生殖细胞发育相关蛋白DAZL抗体产品介绍    background:

The DAZ (Deleted in AZoospermia) gene family encodes potential RNA binding proteins that are expressed in prenatal and postnatal germ cells of males and females. The protein encoded by this gene is localized to the nucleus and cytoplasm of fetal germ cells and to the cytoplasm of developing oocytes. In the testis, this protein is localized to the nucleus of spermatogonia but relocates to the cytoplasm during meiosis where it persists in spermatids and spermatozoa. Transposition and amplification of this autosomal gene during primate evolution gave rise to the DAZ gene cluster on the Y chromosome. Mutations in this gene have been linked to severe spermatogenic failure and infertility in males. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2010]. 

Function:
RNA-binding protein, which is essential for gametogenesis. Plays a central role during spermatogenesis. May act by binding to the 3'-UTR of mRNA and thereby regulating the translation of key transcripts.

Subunit:
Homodimer and heterodimer. Forms a heterodimer with DAZ. Interacts with BOLL, DAZAP1 and DAZAP2. Interacts with PUM2.

Subcellular Location:
Cytoplasm. Nucleus. Predominantly cytoplasmic. Nuclear in spermatogonia until near the end of the meiotic prophase and cytoplasmic localization from then onward.

Tissue Specificity:
Testis specific.

Similarity:
Belongs to the RRM DAZ family.
Contains 1 DAZ-like domain.
Contains 1 RRM (RNA recognition motif) domain.

Database links:
UniProtKB/Swiss-Prot: Q92904.1

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.    

生殖细胞发育相关蛋白DAZL抗体

hz-2138P PARP(poly ADP-ribose polymerase)N-Terminus  多腺苷二磷酸多聚酶抗原(N端)

hz-1201P PAX8(Paired box gene 8)  配对盒基因8抗原

hz-1102P PAX9(Paired box gene 9)  配对盒基因9抗原

hz-1159P P-cadherin(placental)  P-钙粘附分子抗原

hz-1617P LI-cadherin(liver-intestine cadherin)  肝肠钙粘连蛋白抗原

hz-1608P PDCD4(programmed cell death 4)  凋亡相关蛋白4抗原

hz-1333P TFAR19(TF-1 cell apoptsis-related gene 19)  凋亡相关蛋白TFAR19抗原

hz-2215P PCNA(phosphos Dyr211)peptide  磷酸化增殖细胞核多肽抗原

hz-1345P PCX/PODXL(Podocalyxin)  足细胞特异蛋白抗原

hz-1316P PDGF-BB peptide  血小板源性生长因子-BB抗原

hz-0923P Pdx1(pancreatic and duodenal homeobox 1)  胰十二指肠同源异型盒基因抗原

hz-2219P pectinesterase inhibitor 18 peptide  果胶酶抗原

hz-1084P PEG10(Paternally expressed gene 10)  肝癌高表达基因抗原

hz-2106P PENK/Enkephalin A(Preproencephalin A)  脑啡肽

hz-0584P PEPT2 (Peptide-transporters 2)  肠道肽转运蛋白2/小肽转运蛋白2抗原

hz-2469P PERK(PRKR-like endoplasmic reticulum kinase)  蛋白激酶R样内质网激酶抗原

hz-0796P FSCN1 (Fascin 1 protein; fascin homolog 1, actin-bundling protein)  纤维束蛋白同源物1/肌动蛋白集束蛋白/圆线虫紫癜 抗原

hz-0563P P-GP(P-glycoprotein)  P-糖蛋白抗原

hz-1551P Pepsinogen C peptide  胃蛋白酶原C蛋白抗原

hz-1832P PGC-1 Alpha(peroxisome proliferator-activated receptor- Gamma coactivator 1 Alpha)  过氧化物酶体增殖物激活受体γ辅激活子1α抗原

hz-0823P PGRN (progranulin)  颗粒蛋白前体抗原

hz-1449P PHB(Prohibitin)  抑制素/肿瘤抑制因子抗原

hz-0520P PKA(Protein Kinase A)  蛋白激酶A(多肽)

hz-1098P PLAU/uPA (Plasminogen activator,urokinase)  尿激酶型纤溶酶原激活因子（多肽）

hz-1048P Podoplanin Protein  平足蛋白抗原

hz-0891P Pokhzon (POK Erythroid Myeloid Ontogenic factor)  “扑克蒙”蛋白又称“波克曼”蛋白

hz-2157P Polycystin 1(Polycystic Kidney Disease 1)  多囊肾蛋白1抗原

hz-2158P Polycystin 2(polycystic kidney disease 2)  多囊肾蛋白2抗体

hz-0876P phospho-AKT1/PKB1/2/3(pThr473)peptide  磷酸化蛋白激酶B抗原（丝氨酸磷酸化位点：473）

hz-1436P RKIP(Raf kinase inhibitor protein)  Raf激酶抑制蛋白抗原

hz-2146P pre-X protein[Hepatitis B virus]N-Terminus  乙肝病毒pre-X蛋白抗原（N端）

hz-2147P pre-X protein(CT)[Hepatitis B virus C-Terminus]  乙肝病毒pre-X蛋白抗原（C端）