英文名称    phospho-DAP Kinase 1 (Ser308)    

中文名称    磷酸化凋亡相关蛋白激酶1抗体    

别    名    DAP Kinase 1 (phospho S308); p- DAP Kinase 1 (phospho S308); DAK1; DAP K1; DAP kinase 1; DAPK 1; DAPK; DAPK1; DAPK1_HUMAN; Death Associated Protein Kinase 1; Death-associated protein kinase 1; DKFZp781I035;    

说 明 书    0.1ml      

产品类型    磷酸化抗体     

研究领域    肿瘤  细胞生物  信号转导  细胞凋亡  新陈代谢      

抗体来源    Rabbit    

克隆类型    Polyclonal    

交叉反应    Human, Mouse, Rat,     

产品应用    WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 磷酸化凋亡相关蛋白激酶1抗体 （石蜡切片需做抗原修复） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.    

分 子 量    157kDa    

细胞定位    细胞浆     

性    状    Lyophilized or Liquid    

浓    度    1mg/1ml    

免 疫 原    KLH conjugated synthesised phosphopeptide derived from human DAP Kinase 1 around the phosphorylation site of Ser308    

亚    型    IgG    

纯化方法    affinity purified by Protein A    

储 存 液    Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4    

保存条件    Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.    

磷酸化凋亡相关蛋白激酶1抗体 产品介绍    background:

DAPK1 expression is frequently lost in human carcinomas and B-cell leukemia, and lower levels of expression correlates with high rates of metastasis. The loss of DAPK expression provides a link between suppression of apoptosis and metastasis. DAPK1 is thought be involved in an early apoptotic checkpoint which eliminates premalignant cells from cancer formation. Studies in bladder cancer patients have also shown that hypermethylation of DAPK1 correlates to high recurrence rates and thus DAPK1 may be used as a prognostic marker. DAPK1 is also reportedly a molecular regulator of neuronal death in epilepsy.

Function:
Calcium/calmodulin-dependent serine/threonine kinase which acts as a positive regulator of apoptosis.

Subcellular Location:
Cytoplasm. Colocalizes with the actin filament system.

Post-translational modifications:
Ubiquitinated by the BCR(KLHL20) E3 ubiquitin ligase complex, leading to its degradation by the proteasome.    

磷酸化凋亡相关蛋白激酶1抗体 

hz-0437P-hzy3 Streptavidin/Cy3  荧光素Cy3标记链霉亲和素

hz-0312P-hzy3 Avidin/Cy3  荧光素Cy3标记亲合素

hz-0362P-hzy3 Protein A/Cy3  Cy3标记蛋白A

hz-0295P-hzy3 Rabbit IgG/Cy3  荧光素Cy3标记兔IgG(细胞流式同型对照)

hz-0296P-hzy3 Mouse IgG/Cy3  荧光素Cy3标记小鼠IgG(细胞流式同型对照)

hz-0294P-hzy3 Goat IgG/Cy3  荧光素Cy3标记羊IgG(细胞流式同型对照)

hz-0293P-hzy3 Rat IgG/Cy3  荧光素Cy3标记大鼠IgG(细胞流式同型对照)

hz-0326P-hzy3 Bovine IgG/Cy3  荧光素Cy3标记牛IgG

hz-0327P-hzy3 Bovine IgM/Cy3  荧光素Cy3标记牛IgM

hz-0310P-hzy3 Chicken IgG/Cy3  荧光素Cy3标记鸡IgG

hz-0314P-hzy3 Chicken IgM/Cy3  荧光素Cy3标记鸡IgM

hz-0303P-hzy3 dog IgG/Cy3  荧光素Cy3标记狗IgG

hz-0373P-hzy3 dog IgM/Cy3  荧光素Cy3标记狗IgM

hz-0370P-hzy3 Goat IgM/Cy3  荧光素Cy3标记羊IgM

hz-0358P-hzy3 Guinea pig IgG/Cy3  荧光素Cy3标记豚鼠IgG

hz-0375P-hzy3 Guinea pig IgM/Cy3  荧光素Cy3标记豚鼠IgM

hz-0308P-hzy3 Horse IgG/Cy3  荧光素Cy3标记马IgG

hz-0374P-hzy3 Horse IgM/Cy3  荧光素Cy3标记马IgM

hz-0297P-hzy3 human IgG/Cy3  荧光素Cy3标记人IgG

hz-0345P-hzy3 human IgM/Cy3  荧光素Cy3标记人IgM

hz-0360P-hzy3 human IgA/Cy3  荧光素Cy3标记人IgA

hz-0335P-hzy3 Monkey IgG/Cy3  荧光素Cy3标记猴IgG

hz-0336P-hzy3 Monkey IgM/Cy3  荧光素Cy3标记猴IgM

hz-0368P-hzy3 Mouse IgM/Cy3  荧光素Cy3标记小鼠IgM

hz-0309P-hzy3 pig IgG/Cy3  荧光素Cy3标记猪IgG

hz-0777P-hzy3 Mink IgG/Cy3  荧光素Cy3标记水貂IgG

hz-0369P-hzy3 Rabbit IgM/Cy3  荧光素Cy3标记兔IgM

hz-0346P-hzy3 Rat IgM/Cy3  荧光素Cy3标记大鼠IgM

hz-0884P-hzy3 rHIL-1Ra/Cy3  荧光素Cy3标记重组人白介素-1受体拮抗剂

hz-0789P-hzy3 Insulin Protein/Cy3  荧光素Cy3标记猪胰岛素蛋白

hz-0225P-hzy3 KLH/Cy3  荧光素Cy3标记血蓝蛋白

hz-0283P-hzy3 OVA (Ovalbumin)/Cy3  荧光素Cy3标记鸡卵白蛋白

hz-0945P-hzy3 Albumin /Cy3  荧光素Cy3标记人血白蛋白