产品详情
英文名称 DHODH
中文名称 二氢乳清酸脱氢酶抗体
别 名 DHOdehase; Dhodh; Dihydroorotate dehydrogenase (quinone); Dihydroorotate dehydrogenase; Dihydroorotate dehydrogenase mitochondrial; Dihydroorotate oxidase; Human complement of yeast URA1; mitochondrial; PYRD_HUMAN.
说 明 书 0.1ml 0.2ml
研究领域 细胞生物 信号转导 细胞骨架
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse, Rat, Dog, Cow, Horse, Rabbit, Sheep,
产品应用 WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 二氢乳清酸脱氢酶抗体(石蜡切片需做抗原修复)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 43kDa
性 状 Lyophilized or Liquid
浓 度 1mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from human DHODH
亚 型 IgG
纯化方法 affinity purified by Protein A
储 存 液 Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
二氢乳清酸脱氢酶抗体产品介绍 background:
The protein encoded by this gene catalyzes the fourth enzymatic step, the ubiquinone-mediated oxidation of dihydroorotate to orotate, in de novo pyrimidine biosynthesis. This protein is a mitochondrial protein located on the outer surface of the inner mitochondrial membrane. [provided by RefSeq, Jul 2008]
Function:
Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor.
Subcellular Location:
Mitochondrion inner membrane.
Post-translational modifications:
The uncleaved transit peptide is required for mitochondrial targeting and proper membrane integration.
DISEASE:
Defects in DHODH are the cause of postaxial acrofacial dysostosis (POADS) [MIM:263750]; also known as Miller syndrome. POADS is characterized by severe micrognathia, cleft lip and/or palate, hypoplasia or aplasia of the posterior elements of the limbs, coloboma of the eyelids and supernumerary nipples. POADS is a very rare disorder: only 2 multiplex families, each consisting of 2 affected siblings born to unaffected, nonconsanguineous parents, have been described among a total of around 30 reported cases.
Similarity:
Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily.
Gene ID:
1723
Database links:
Entrez Gene: 1723 Human
Entrez Gene: 533873 Cow
Entrez Gene: 610755 Dog
Entrez Gene: 56749 Mouse
Entrez Gene: 65156 Rat
Entrez Gene: 494065 Zebrafish
Omim: 126064 Human
SwissProt: Q02127 Human
SwissProt: O35435 Mouse
SwissProt: Q63707 Rat
Unigene: 654427 Human
Unigene: 23894 Mouse
Unigene: 81502 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
二氢乳清酸脱氢酶抗体
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