英文名称    DUSP18    

中文名称    双特异性磷酸酶抗体18抗体    

别    名    Dual specificity protein phosphatase 18; DUS18_HUMAN; DUSP18; LMW-DSP20; LMWDSP20; Low molecular weight dual specificity phosphatase 20.    

说 明 书    0.2ml      

研究领域    细胞生物  信号转导  激酶和磷酸酶      

抗体来源    Rabbit    

克隆类型    Polyclonal    

交叉反应    Human, Mouse, Rat, Pig, Cow, Horse, Sheep,     

产品应用    WB=1:100-500 ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 双特异性磷酸酶抗体18抗体（石蜡切片需做抗原修复） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.    

分 子 量    21kDa    

细胞定位    细胞核 细胞浆     

性    状    Lyophilized or Liquid    

浓    度    1mg/1ml    

免 疫 原    KLH conjugated synthetic peptide derived from human DUSP18    

亚    型    IgG    

纯化方法    affinity purified by Protein A    

储 存 液    Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4    

保存条件    Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.    

双特异性磷酸酶抗体18抗体产品介绍    background:

Dual-specificity phosphatases (DUSPs) constitute a large heterogeneous subgroup of the type I cysteine-based protein-tyrosine phosphatase superfamily. DUSPs are characterized by their ability to dephosphorylate both tyrosine and serine/threonine residues. They have been implicated as major modulators of critical signaling pathways. DUSP18 contains the consensus DUSP C-terminal catalytic domain but lacks the N-terminal CH2 domain found in the MKP (mitogen-activated protein kinase phosphatase) class of DUSPs (see MIM 600714) (summary by Patterson et al., 2009 [PubMed 19228121]).[supplied by OMIM, Dec 2009]

Function:
Can dephosphorylate single and diphosphorylated synthetic MAPK peptides, with preference for the phosphotyrosine and diphosphorylated forms over phosphothreonine. In vitro, dephosphorylates p-nitrophenyl phosphate (pNPP).

Subcellular Location:
Cytoplasm. Nucleus.

Tissue Specificity:
Widely expressed with highest levels in liver, brain, ovary and testis.

Similarity:
Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.
Contains 1 tyrosine-protein phosphatase domain.

Gene ID:
150290

Database links:

Entrez Gene: 150290 Human

Entrez Gene: 75219 Mouse

Omim: 611446 Human

SwissProt: Q8NEJ0 Human

SwissProt: Q8VE01 Mouse

Unigene: 517544 Human

Unigene: 32588 Mouse

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.    

双特异性磷酸酶抗体18抗体

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hz-7848R SKA3  纺锤体和着丝粒相关蛋白3抗体

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hz-7858R CEND1  细胞周期通道和神经细胞分化蛋白1抗体

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hz-7863R FSTL5  卵泡抑素相关蛋白5抗体

hz-7864R Flightless 1  凝溶胶蛋白家族Fli-1抗体

hz-7865R GPSM1  G蛋白信号调节蛋白1抗体

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hz-7875R SCEL  SCEL蛋白抗体

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