英文名称    alpha Elastin/Tropoelastin    

中文名称    α弹性蛋白抗体    

别    名    Elastin alpha; Elastin; Elastin isoform a; ELN; ELN_HUMAN; FLJ38671; FLJ43523; Supravalvular aortic stenosis; SVAS; Tropoelastin; WBS; Williams Beuren syndrome; Williams syndrome region; WS.    

说 明 书    0.1ml  0.2ml  1ml    

研究领域    肿瘤  免疫学  神经生物学  转录调节因子      

抗体来源    Rabbit    

克隆类型    Polyclonal    

交叉反应    Human, Mouse, Rat,     

产品应用    WB=1:100-500 ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 α弹性蛋白抗体（石蜡切片需做抗原修复） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.    

分 子 量    70kDa    

细胞定位    细胞外基质 分泌型蛋白     

性    状    Lyophilized or Liquid    

浓    度    1mg/1ml    

免 疫 原    KLH conjugated synthetic peptide derived from human Elastin    

亚    型    IgG    

纯化方法    affinity purified by Protein A    

储 存 液    0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide    

保存条件    Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.    

α弹性蛋白抗体产品介绍    background:

Elastin is a major structural protein of tissues such as aorta, which must expand rapidly and recover completely. Elastin chains are cross-linked together into an extensible 3D network. It is a molecular determinant of late arterial morphogenesis, stabilizing arterial structure by regulating proliferation and organization of vascular smooth muscle. Elastin forms a complex with BGN and MFAP2.

Function:
Major structural protein of tissues such as aorta and nuchal ligament, which must expand rapidly and recover completely. Molecular determinant of the late arterial morphogenesis, stabilizing arterial structure by regulating proliferation and organization of vascular smooth muscle.

Subunit:
The polymeric elastin chains are cross-linked together into an extensible 3D network. Forms a ternary complex with BGN and MFAP2. Interacts with MFAP2 via divalent cations (calcium > magnesium > manganese) in a dose-dependent and saturating manner.

Subcellular Location:
Secreted, extracellular space, extracellular matrix. Note=Extracellular matrix of elastic fibers.

Tissue Specificity:
Expressed within the outer myometrial smooth muscle and throughout the arteriolar tree of uterus (at protein level). Also expressed in the large arteries, lung and skin.

DISEASE:
Defects in ELN are the cause of cutis laxa, autosomal dominant, type 1 (ADCL1) . A connective tissue disorder characterized by loose, hyperextensible skin with decreased resilience and elasticity leading to a premature aged appearance. Face, hands, feet, joints, and torso may be differentially affected. Additional variable clinical features are gastrointestinal diverticula, hernia, and genital prolapse. Rare manifestations are pulmonary artery stenosis, aortic aneurysm, bronchiectasis, and emphysema. 

Similarity:
Belongs to the elastin family.

Gene ID:
2006

Database links:

Entrez Gene: 2006 Human

Entrez Gene: 13717 Mouse

Omim: 130160 Human

SwissProt: P15502 Human

SwissProt: P54320 Mouse

Unigene: 647061 Human

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.    

α弹性蛋白抗体

hz-0659R EPEC/E.coli  肠致病性大肠杆菌抗体

hz-2100R E.coli/EPEC  大肠埃希菌菌体蛋白抗体

hz-1555R E.coli O139  抗志贺毒素大肠杆菌O139抗体（仔猪水肿病志贺毒素大肠杆菌O139）

hz-2351R E. coli LPS  大肠杆菌脂多糖抗体

hz-1876R EP3  前列腺素E受体3抗体

hz-5884R Endomucin  内皮粘蛋白hzCN抗体

hz-1763R EphA1/Ephrina1/Ephrin A1 Receptor  内皮细胞受体蛋白酪氨酸激酶A抗体（肿瘤坏死因子α诱导蛋白4）

hz-1764R EphA4  酪氨酸蛋白激酶A4抗体

hz-2764R Ephrin B  Ephrin B抗体

hz-3217R phospho-Ephrin B(Tyr329)  磷酸化Ephrin B抗体

hz-3167R phospho-Ephrin B(Tyr316)  磷酸化Ephrin B抗体

hz-3128R phospho-Ephrin B(Ser300)  磷酸化Ephrin B抗体

hz-3129R phospho-Ephrin B(Tyr324/329)  磷酸化Ephrin B抗体

hz-6047R Ephrin A3/EFNA3  酪氨酸蛋白激酶A3受体抗体

hz-6048R Ephrin A5  酪氨酸蛋白激酶A5受体抗体

hz-5887R HPSE2  乙酰肝素酶样蛋白抗体

hz-0485R EphA2/Eph receptor A2  内皮细胞受体蛋白酪氨酸激酶抗体

hz-3126R Phospho-EphA2(Tyr594)  磷酸化酪氨酸蛋白激酶A2受体抗体

hz-1455R EphA4 R/Eph receptor A4  酪氨酸蛋白激酶A4受体抗体

hz-0247R EphB2 R  酪氨酸蛋白激酶受体B2抗体

hz-2343R EPO  红细胞生成素抗体

hz-1424R EPOR  红细胞生成素受体抗体

hz-3880R EPHX2  胞浆环氧化物水解酶抗体

hz-2365R Eppin  附睾蛋白酶抑制蛋白

hz-3881R EPX  嗜酸性粒细胞过氧化物酶抗体

hz-2571R EphB6  酪氨酸蛋白激酶受体B6抗体

hz-3848R EPS8  表皮生长因子受体底物8抗体

hz-0725R ERα/ESR1  雌激素受体α抗体

hz-0021M ERAB/HSD17B10  内质网Aβ相关结合蛋白抗体

hz-5890R Lumican  基膜聚糖蛋白抗体

hz-1726R ERCC1  DNA切除修复蛋白1抗体

hz-0022R ERK2/MAPK1  丝裂原活化蛋白激酶1抗体

hz-1736R phospho-MEK1/MAPKK1(Ser298)  磷酸化丝裂原活化蛋白激酶激酶1抗体

hz-3269R phospho-MEK1(Thr286)  磷酸化丝裂原活化蛋白激酶激酶1抗体

hz-3270R Phospho-MEK1/2(Ser218/222)  磷酸化丝裂原活化蛋白激酶激酶1/2抗体

hz-3722R Phospho-MEK1/2(Ser222)  磷酸化丝裂原活化蛋白激酶激酶1/2抗体