产品详情
英文名称 Enkephalin
中文名称 脑啡肽抗体
别 名 EP-ENK; nkephalin A; PENK; P ENK; Preproencephalin A; Proenkephalin A; Proenkephalin; Synenkephalin; Opioid growth factor; OGF; Leu enkephalin; Met enkephalin; PENK protein; ProenkephalinA; lipotropin gamma; COLI_HUMAN.
说 明 书 0.1ml 0.2ml
研究领域 神经生物学
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse, Rat, Chicken, Dog, Horse,
产品应用 WB=1:100-500 ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 脑啡肽抗体(石蜡切片需做抗原修复)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 29kDa
细胞定位 分泌型蛋白
性 状 Lyophilized or Liquid
浓 度 1mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from human PENK
亚 型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
脑啡肽抗体产品介绍 background:
This gene encodes a polypeptide hormone precursor that undergoes extensive, tissue-specific, post-translational processing via cleavage by subtilisin-like enzymes known as prohormone convertases. There are eight potential cleavage sites within the polypeptide precursor and, depending on tissue type and the available convertases, processing may yield as many as ten biologically active peptides involved in diverse cellular functions. The encoded protein is synthesized mainly in corticotroph cells of the anterior pituitary where four cleavage sites are used; adrenocorticotrophin, essential for normal steroidogenesis and the maintenance of normal adrenal weight, and lipotropin beta are the major end products. In other tissues, including the hypothalamus, placenta, and epithelium, all cleavage sites may be used, giving rise to peptides with roles in pain and energy homeostasis, melanocyte stimulation, and immune modulation. These include several distinct melanotropins, lipotropins, and endorphins that are contained within the adrenocorticotrophin and beta-lipotropin peptides. Mutations in this gene have been associated with early onset obesity, adrenal insufficiency, and red hair pigmentation. Alternatively spliced transcript variants encoding the same protein have been described. [provided by RefSeq, Jul 2008].
Function:
ACTH stimulates the adrenal glands to release cortisol.
MSH (melanocyte-stimulating hormone) increases the pigmentation of skin by increasing melanin production in melanocytes.
Beta-endorphin and Met-enkephalin are endogenous opiates.
Subcellular Location:
Secreted.
Tissue Specificity:
ACTH and MSH are produced by the pituitary gland.
Post-translational modifications:
Specific enzymatic cleavages at paired basic residues yield the different active peptides.
O-glycosylated; reducing sugar is probably N-acetylgalactosamine.
DISEASE:
Defects in POMC may be associated with susceptibility to obesity (OBESITY) [MIM:601665]. It is a condition characterized by an increase of body weight beyond the limitation of skeletal and physical requirements, as the result of excessive accumulation of body fat.
Defects in POMC are the cause of pro-opiomelanocortinin deficiency (POMCD) [MIM:609734]. Affected individuals present early-onset obesity, adrenal insufficiency and red hair.
Similarity:
Belongs to the POMC family.
Gene ID:
5443
Database links:
Entrez Gene: 5443 Human
Entrez Gene: 18976 Mouse
Entrez Gene: 24664 Rat
Omim: 176830 Human
SwissProt: P01189 Human
SwissProt: P01193 Mouse
SwissProt: P01194 Rat
Unigene: 1897 Human
Unigene: 277996 Mouse
Unigene: 108195 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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