产品详情
英文名称 CASP8 and FADD-like apoptosis regulator subunit p43
中文名称 凋亡调节基因之一抗体
别 名 CASP8 and FADD-like apoptosis regulator subunit p43; Flice-like Inhibitory protein; c FLIP; c FLIPL; c FLIPR; c FLIPS; c-FLIP; CASH; CASP8 and FADD like apoptosis regulator; CASP8 and FADD like apoptosis regulator precursor; CASP8AP1; Caspase Eight Related Protein; Caspase homolog; Caspase Homologue; Caspase Like Apoptosis Regulatory Protein; Caspase related inducer of apoptosis; CASPER; Cellular FLICE like inhibitory protein; CFLA; CFLAR; CLARP; FADD like anti apoptotic molecule; FADD Like Anti-apoptotic Molecule 1; FADD-like antiapoptotic molecule 1; FADD like antiapoptotic molecule 1; FADD Like Apoptosis Regulator; FLAME 1; FLAME; FLAME1; FLAME-1; FLICE Inhibitor Protein; FLIP; FLIPs; I FLICE; I-FLICE; Inhibitor of FLICE; Inhibitor of FLICE; MACH Related Inducer of Toxicity; MACH-related inducer of toxicity; mFLIP; MRIT; USURPIN; Usurpin beta; FLICE-like inhibitory protein short form; FLICE-like inhibitory protein long form; CFLAR_HUMAN; Cellular FLICE-like inhibitory protein.
说 明 书 0.1ml 0.2ml
研究领域 肿瘤 细胞生物 信号转导 细胞凋亡
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse, Rat, Dog, Pig, Cow, Rabbit,
产品应用 WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 凋亡调节基因之一抗体(石蜡切片需做抗原修复)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 12/43kDa
性 状 Lyophilized or Liquid
浓 度 1mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from human CASP8 and FADD-like apoptosis regulator subunit p43
亚 型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
凋亡调节基因之一抗体产品介绍 background:
The protein encoded by this gene is a regulator of apoptosis and is structurally similar to caspase-8. However, the encoded protein lacks caspase activity and appears to be itself cleaved into two peptides by caspase-8. Several transcript variants encoding different isoforms have been found for this gene, and partial evidence for several more variants exists. [provided by RefSeq, Feb 2011]
Function:
Apoptosis regulator protein which may function as a crucial link between cell survival and cell death pathways in mammalian cells. Acts as an inhibitor of TNFRSF6 mediated apoptosis. A proteolytic fragment (p43) is likely retained in the death-inducing signaling complex (DISC) thereby blocking further recruitment and processing of caspase-8 at the complex. Full length and shorter isoforms have been shown either to induce apoptosis or to reduce TNFRSF-triggered apoptosis. Lacks enzymatic (caspase) activity.
Subunit:
TNFRSF6 stimulation triggers recruitment to the death-inducing signaling complex (DISC) formed by TNFRSF6, FADD and caspase-8. A proteolytic fragment (p43) stays associated with the DISC. Also interacts with caspase-10, caspase-3, TRAF1, TRAF2 and Bcl-X(L) (in vitro). Interacts with HBV protein X.
Tissue Specificity:
Widely expressed. Higher expression in skeletal muscle, pancreas, heart, kidney, placenta, and peripheral blood leukocytes. Also detected in diverse cell lines. Isoform 8 is predominantly expressed in testis and skeletal muscle.
Post-translational modifications:
Proteolytically processed; probably by caspase-8. Processing likely occurs at the DISC and generates subunit p43 and p12.
Similarity:
Belongs to the peptidase C14A family.
Contains 2 DED (death effector) domains.
Gene ID:
8837
凋亡调节基因之一抗体
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hz-1137P SSTR1 (somatostatin receptor 1) 生长抑素受体1(SSTR1)抗原
hz-1138P SSTR2 (somatostatin receptor 2) 生长抑素受体2抗原
hz-1368P SSTR3 peptide 生长抑素受体3抗原
hz-1139P SSTR5 (somatostatin receptor 5) 生长抑素受体5抗原
hz-1317P STAT1(signal transducers and activators of transcription 1) 信号转导与转录激活因子1抗原
hz-1657P phospho-STAT1(p-Tyr701) peptide 磷酸化信号转导与转录激活因子1抗原
hz-1141P STAT3(signal transducers and activators of transduction3) 信号转导和转录激活因子3抗原
hz-1142P STAT5(signal transducers and activators of transduction5) 信号转导和转录激活因子5(STAT5)抗原
hz-1143P STAT6(signal transducers and activators of transduction 6) 信号转导和转录激活因子6抗原
hz-0629P SULT1E1(Estrogen Sulfotranferase) 雌激素硫酸转移酶抗原
hz-1499P SUMO 类泛素蛋白
hz-0622P Gamma-Synuclein/SNCG 核突触蛋白-γ抗原
hz-0885P phospho-Tau protein (pThr489) peptide 磷酸化微管相关蛋白多肽
hz-1369P MAP-2(microtubule associated protein 2) 微管相关蛋白2抗原
hz-1847P MAP1A/Mtap1a(microtubule associated protein 1A) 微管相关蛋白1A抗原
hz-1104P TBX2/T-box2(T-box Protein 2) 新型抑癌基因(多肽)
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hz-0822P TDP-43/TARDBP (tar DNA binding protein) Tar DNA 结合蛋白43抗原
hz-1039P Tenascin 固生蛋白抗原
hz-2101P Thz 1/CD248(Tumor endothelial marker 1 precursor) 内涎蛋白/内皮唾液酸蛋白抗原
hz-0535P TFF3 (trefoil factor3) 三叶肽因子3(多肽)
hz-1144P TFPI-2 (tissue factor pathway inhibitor-2) 组织因子途径抑制剂-2抗原
hz-1838P TIEG1/KLF10(TGF-beta inducible early response gene 1) TGF-β诱导早期应答基因1抗原
hz-0638P TGF- BetaR1/ALK (TGF-beta receptor type I) 转移生长因子–β受体1抗原
hz-1276P Erdj5/DNAJC10 Erdj5/DNAJC10多肽
hz-1334P Tie1/JTK14 peptide 上皮生长因子样域酪氨酸激酶1抗原
hz-1300P Tie2(Porcine tyrosine kinase with immunoglobulin-like and EGF-like domains 2) 上皮生长因子样域酪氨酸激酶2抗原
hz-1501P Rarres2/TIG2/Chhzerin(Retinoic acid receptor responder protein 2) 视黄酸受体应答蛋白2抗原
hz-1444P TLR3 (Toll-like receptor 3) Toll样受体3抗原
hz-1021P TLR4/CD284 (Toll-like receptor 4) Toll样受体4抗原
hz-1197P TLR5/CD285 (Toll-like receptor 5) Toll样受体5抗原
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