产品详情
英文名称 SEMA4F
中文名称 跨膜蛋白SEMA4F抗体
别 名 M SEMA; m Sema M; PRO2353; Sema domain immunoglobulin domain (Ig) transmembrane; Sema M; Sema W; SEMAM; Semaphorin M; Semaphorin W; SEMAW; SEM4F_HUMAN. 跨膜蛋白SEMA4F抗体
说 明 书 0.2ml
研究领域 细胞生物 神经生物学 细胞分化
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse, Rat, Dog, Cow, Horse,
产品应用 WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 Flow-Cyt=1:100-500 ICC=1:100-500 IF=1:100-500 (石蜡切片需做抗原修复)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 80kDa
细胞定位 细胞膜
性 状 Lyophilized or Liquid
浓 度 1mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from human SEMA4F (239-288aa)
亚 型 IgG
纯化方法 affinity purified by Protein A
储 存 液 Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
跨膜蛋白SEMA4F抗体 产品介绍 background:
Semaphorins are a family of cell surface and secreted proteins that are conserved from insects to humans. Members of this family of proteins are approximately 750 amino acids in length (including signal sequences) and are defined by a conserved extracellular “semaphorin” domain of approximately 500 amino acids containing 14-16 cysteines, blocks of conserved sequences and no obvious repeats. Secreted and cell-bound semaphorins chemically attract and repel the growth of neural axons, guiding the development of intricate networks of neural tissue. SEMA4F (semaphorin-4F), also known as SEMAM, SEMAW or PRO2353, is a 770 amino acid member of the semaphorin family. Localized to the membrane, SEMA4F is a single-pass type I protein that is involved in growth cone collapse of retinal ganglion-cell axons. SEMA4F is highly expressed in postnatal brain and lung and contains one immunogloblin-like (Ig-like) domain, one PSI domain and one semaphorin domain. Two isoforms exist due to alternative splicing events.
Function:
SEMA4F has growth cone collapse activity against retinal ganglion-cell axons.
Subcellular Location:
Membrane; Single-pass type I membrane protein
Similarity:
Belongs to the semaphorin family.
Contains 1 Ig-like C2-type (immunoglobulin-like) domain.
Contains 1 PSI domain.
Contains 1 Sema domain.
Database links:
UniProtKB/Swiss-Prot: O95754.2
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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