英文名称    FOXI1    

中文名称    叉头蛋白I1抗体    

别    名    FKH10; FKHL10; Forkhead (Drosophila) like 10; Forkhead box I1; Forkhead box protein I1; Forkhead like 10; Forkhead related activator 6; Forkhead related transcription factor 6; Forkhead-related protein FKHL10; FREAC 6; FREAC6; Hepatocyte nuclear factor 3 forkhead homolog 3; HFH 3; HFH3; HNF 3/fork head homolog 3; HNF-3 fork-head homolog 3; Human HNF-3 fork-head homolog-3 HFH-3 mRNA complete cds; MGC34197; FOXI1_HUMAN.    

说 明 书    0.2ml      

研究领域    神经生物学  转录调节因子  表观遗传学      

抗体来源    Rabbit    

克隆类型    Polyclonal    

交叉反应    Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Rabbit, Sheep,     

产品应用    WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 叉头蛋白I1抗体（石蜡切片需做抗原修复） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.    

分 子 量    41kDa    

细胞定位    细胞核     

性    状    Lyophilized or Liquid    

浓    度    1mg/1ml    

免 疫 原    KLH conjugated synthetic peptide derived from human FOXI1    

亚    型    IgG    

纯化方法    affinity purified by Protein A    

储 存 液    Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4    

保存条件    Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.    

叉头蛋白I1抗体产品介绍    background:

FOXI1 is a member of the FOX family of transcription factors. The FOX family is a large group of proteins (consisting of at least 43 members) that share a common DNA binding domain termed winged-helix or forkhead domain. FOX transcription factors play important roles in development, differentiation, aging and hormone responsiveness. Localizing to the nucleus, FOXI1 functions as a transcription factor. Mice with mutated forms of FOXI1 show defects in ear development, implying that FOXI1 plays a significant role in the developmental pathway of ears and, in particular, the cochlea and vestibulum. FOXI1 is an upstream transcription regulator of Pendrin (a protein associated with deafness), suggesting a role for FOXI1 in the pathogenesis of Pendred syndrome (PS), a condition of nonsyndromic hearing loss and enlarged vestibular aqueduct (EVA).

Function:
FOXI1 belongs to the forkhead family of transcription factors which are characterized by a distinct forkhead domain. This gene may play an important role in the development of the cochlea and vestibulum, as well as embryogenesis. Mutations in this gene may be associated with the common cavity phenotype. Two transcript variants encoding different isoforms have been found for this gene.

Subcellular Location:
Nuclear.

Tissue Specificity:
Expressed in kidney. 

Similarity:
Contains 1 fork-head DNA-binding domain. 

Database links:
UniProtKB/Swiss-Prot: Q12951.3

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.    

叉头蛋白I1抗体

hz-0368R-AF555 Rabbit Anti-mouse IgM/Alexa Fluor 555  Alexa Fluor 555标记的兔抗小鼠IgM

hz-0368R-AF647 Rabbit Anti-mouse IgM/Alexa Fluor 647  Alexa Fluor 647标记的兔抗小鼠IgM

hz-0368R-PE-hzy5.5 Rabbit Anti-mouse IgM/PE-Cy5.5  PE-Cy5.5标记的兔抗小鼠IgM

hz-0368R-PE-hzy7 Rabbit Anti-mouse IgM/PE-Cy7  PE-Cy7标记的兔抗小鼠IgM

hz-0368R-AF350 Rabbit Anti-mouse IgM/Alexa Fluor 350  Alexa Fluor 350标记的兔抗小鼠IgM

hz-0368R-AF488 Rabbit Anti-mouse IgM/Alexa Fluor 488  Alexa Fluor 488标记的兔抗小鼠IgM

hz-0368R-hzy3 Rabbit Anti-mouse IgM/Cy3  Cy3标记的兔抗小鼠IgM

hz-0368R-RBIThz Rabbit Anti-mouse IgM/RBITC  罗丹明标记的兔抗小鼠IgM

hz-0368R-FIThz Rabbit Anti-mouse IgM/FITC  FITC标记的兔抗小鼠IgM

hz-0330R-FIThz Rabbit anti-mouse Kappa light chain/FITC  FITC标记的兔抗小鼠k链

hz-0330R-AP Rabbit anti-mouse Kappa light chain/AP  碱性磷酸酶（AP）标记的兔抗小鼠k链

hz-0330R-RBIThz Rabbit anti-mouse Kappa light chain/RBITC  罗丹明标记的兔抗小鼠k链

hz-0330R-Gold Rabbit anti-mouse Kappa light chain/Gold  胶体金标记的兔抗小鼠k链

hz-0330R-HRP Rabbit anti-mouse Kappa light chain/HRP  辣根过氧化物酶标记的兔抗小鼠k链

hz-0330R-Bio Rabbit anti-mouse Kappa light chain/Bio  生物素标记的兔抗小鼠k链

hz-0330R-hzy3 Rabbit anti-mouse Kappa light chain/Cy3  Cy3标记的兔抗小鼠k链

hz-0330R-hzy5 Rabbit anti-mouse Kappa light chain/Cy5  Cy5标记的兔抗小鼠k链

hz-0330R-hzy5.5 Rabbit anti-mouse Kappa light chain/Cy5.5  Cy5.5标记的兔抗小鼠k链

hz-0330R-hzy7 Rabbit anti-mouse Kappa light chain/Cy7  Cy7标记的兔抗小鼠k链

hz-0330R-PE Rabbit anti-mouse Kappa light chain/PE  PE标记的兔抗小鼠k链

hz-0330R-PE-hzy3 Rabbit anti-mouse Kappa light chain/PE-Cy3  PE-Cy3标记的兔抗小鼠k链

hz-0330R-PE-hzY5 Rabbit anti-mouse Kappa light chain/PE-CY5  PE-CY5标记的兔抗小鼠k链

hz-0330R-APhz Rabbit anti-mouse Kappa light chain/APC  APC标记的兔抗小鼠k链

hz-0330R-AF350 Rabbit anti-mouse Kappa light chain/Alexa Fluor 350  Alexa Fluor 350标记的兔抗小鼠k链

hz-0330R-AF488 Rabbit anti-mouse Kappa light chain/Alexa Fluor 488  Alexa Fluor 488标记的兔抗小鼠k链

hz-0330R-AF555 Rabbit anti-mouse Kappa light chain/Alexa Fluor 555  Alexa Fluor 555标记的兔抗小鼠k链

hz-0330R-AF647 Rabbit anti-mouse Kappa light chain/Alexa Fluor 647  Alexa Fluor 647标记的兔抗小鼠k链

hz-0330R-PE-hzy5.5 Rabbit anti-mouse Kappa light chain/PE-Cy5.5  PE-Cy5.5标记的兔抗小鼠k链

hz-0330R-PE-hzy7 Rabbit anti-mouse Kappa light chain/PE-Cy7  PE-Cy7标记的兔抗小鼠k链

hz-0293R-Bio Rabbit Anti-rat IgG/Bio  生物素标记的兔抗大鼠IgG

hz-0293R-HRP Rabbit Anti-rat IgG/HRP  辣根过氧化物酶标记的兔抗大鼠IgG

hz-0293R-RBIThz Rabbit Anti-rat IgG/RBITC  罗丹明标记的兔抗大鼠IgG

hz-0293R-FIThz Rabbit Anti-rat IgG/FITC  FITC标记的兔抗大鼠IgG