英文名称    SART1    

中文名称    T淋巴细胞识别的鳞状细胞癌抗原抗体    

别    名    Ara 1; ARA1; HOMS 1; HOMS1; hSART 1; hSART1; hSnu 66; hSnu66; IgE autoantigen; MGC2038; SART 1; SART1 259; SART1(259) protein; SART1(800) protein; SART1259; Snu 66; Snu66; Squamous cell carcinoma antigen recognised by T cells; Squamous cell carcinoma antigen recognized by T cells 1; U4/U6.U5 tri snRNP associated 110 kDa protein; U4/U6.U5 tri snRNP associated protein; SNUT1_HUMAN.    

T淋巴细胞识别的鳞状细胞癌抗原抗体           

说 明 书    0.2ml      

研究领域    肿瘤  细胞生物  细胞周期蛋白  细胞分化  t-淋巴细胞      

抗体来源    Rabbit    

克隆类型    Polyclonal    

交叉反应    Human, Mouse, Rat, Pig, Cow, Sheep,     

产品应用    WB=1:100-500 ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.    

分 子 量    90kDa    

细胞定位    细胞核     

性    状    Lyophilized or Liquid    

浓    度    1mg/1ml    

免 疫 原    KLH conjugated synthetic peptide derived from human SART1    

亚    型    IgG    

纯化方法    affinity purified by Protein A    

储 存 液    Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4    

保存条件    Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.    

T淋巴细胞识别的鳞状细胞癌抗原抗体    产品介绍    background:
SART1 encodes two proteins, the SART1(800) protein expressed in the nucleus of the majority of proliferating cells, and the SART1(259) protein expressed in the cytosol of epithelial cancers. The SART1(259) protein is translated by the mechanism of -1 frameshifting during posttranscriptional regulation; its full length sequence is not published yet. The two encoded proteins are thought to be involved in the regulation of proliferation. Both proteins have tumor rejection antigens. The SART1(259) protein possesses tumor epitopes capable of inducing HLA-A2402-restricted cytotoxic T lymphocytes in cancer patients. This SART1(259) antigen may be useful in specific immunotherapy for cancer patients and may serve as a paradigmatic tool for the diagnosis and treatment of patients with atopy. The SART1(259) protein is found to be essential for the recruitment of the tri snRNP to the pre spliceosome in the spliceosome assembly pathway.

Function:
May play a role in mRNA splicing. May also bind to DNA.

Subunit:
Identified in the spliceosome C complex. Part of a tri-snRNP complex. 

Subcellular Location:
Nucleus. Note=Found in the nucleus of mitogen-activated peripheral blood mononuclear cells (PBMCs), tumor cells, or normal cell lines, but not in normal tissues except testis and fetal liver or in unstimulated PBMCs, suggesting preferential expression in proliferating cells.

Tissue Specificity:
Ubiquitously expressed.

Post-translational modifications:
Sumoylated with SUMO2. 
Phosphorylated upon DNA damage, probably by ATM or ATR. 

Similarity:
Belongs to the SNU66/SART1 family.

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.    

T淋巴细胞识别的鳞状细胞癌抗原抗体    

hz-7817R NUBP1  核苷酸结合蛋白1抗体

hz-7818R NUBP2  核苷酸结合蛋白2抗体

hz-7819R NUP37  核孔蛋白Nup37抗体

hz-7820R PARD6B  缺陷性分配同源物β抗体

hz-7821R PELO  PELO蛋白抗体

hz-7822R POC5  细胞中心粒蛋白抗体

hz-7823R POLA2  DNA聚合酶α2抗体

hz-7824R PSF2  PSF2蛋白抗体

hz-7825R PTOP  肾上腺皮质发育异常同源蛋白抗体

hz-7826R RABGAP1  Rab蛋白GTP酶激活蛋白1抗体

hz-7827R RCL/c Myc responsive  c-Myc应答蛋白抗体

hz-7828R RINT1  胞膜间内质网调节蛋白1抗体

hz-7829R RMND1  减数分裂同源蛋白1抗体

hz-7830R SGTA  小谷氨酰胺三角四肽重复区蛋白α抗体

hz-7831R SUGT1  SUGT1蛋白抗体

hz-7832R APC6/CDC16  细胞分裂周期蛋白16抗体

hz-7833R phospho-APC6/CDC16(Ser560)  磷酸化细胞分裂周期蛋白16抗体

hz-7834R Borealin/CDCA8  细胞分裂周期蛋白8抗体

hz-7835R Bub3  有丝分裂蛋白BUB3抗体

hz-7836R Dynamitin/DCTN2  动力蛋白激活蛋白2抗体

hz-7837R EB2/End binding protein 2  微管相关末端结合蛋白2抗体

hz-7838R INSC  有丝分裂相关蛋白INSC抗体

hz-7839R CENPF  有丝分裂着丝粒蛋白F抗体

hz-7840R Mad2L2  有丝分裂阻滞缺陷2样蛋白2抗体

hz-7841R NUDC  细胞核分离基因C蛋白抗体

hz-7842R phospho-NUDC(Ser326)  磷酸化细胞核分离基因C蛋白抗体

hz-7843R NUP160  核孔蛋白NUP160抗体

hz-7844R Ninein/GSK3B interacting protein  GSK3B相互作用蛋白抗体

hz-7845R RASSF7  RAS家族关联结构域蛋白7抗体

hz-7846R SKA1  纺锤体和着丝粒相关蛋白1抗体

hz-7847R SKA2  纺锤体和着丝粒相关蛋白2抗体

hz-7848R SKA3  纺锤体和着丝粒相关蛋白3抗体

hz-7849R TBCD/Beta tubulin cofactor D  微管蛋白β辅助因子D抗体

hz-7850R MPS1/TTK  单极纺锤体蛋白激酶1抗体

hz-7851R katanin p80  剑蛋白p80抗体