英文名称    SPON1    

中文名称    细胞外基质底物反应蛋白1抗体    

别    名    F spondin; F spondin extracellular matrix protein; FSPO; KIAA0762; MGC10724; SPON 1; spondin 1 (f spondin) extracellular matrix protein; Spondin 1; Spondin 1 extracellular matrix protein; Spondin 1 precursor; Spondin1; Vascular smooth muscle cell growth promoting factor; VSGP; VSGP/F spondin.    

细胞外基质底物反应蛋白1抗     

说 明 书    0.1ml  0.2ml      

研究领域    心血管  细胞生物  神经生物学      

抗体来源    Rabbit    

克隆类型    Polyclonal    

交叉反应    Human, Mouse, Rat, Dog, Pig, Cow, Rabbit,     

产品应用    WB=1:100-500 ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.    

分 子 量    86kDa    

细胞定位    细胞外基质 分泌型蛋白     

性    状    Lyophilized or Liquid    

浓    度    1mg/1ml    

免 疫 原    KLH conjugated synthetic peptide derived from human SPON1/F spondin    

亚    型    IgG    

纯化方法    affinity purified by Protein A    

储 存 液    Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4    

保存条件    Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.    

细胞外基质底物反应蛋白1抗产品介绍    background:
SPON1 is a member of a subgroup of the thrombospondin type 1 (TSR) class molecules, defined by two domains of homology, the FS1/FS2 and TSR domains. The TSRs of SPON1 proteins are typical of class 2 TSRs. SPON1, which is similar to thrombospondin, is a extracellular matrix attached molecule that promotes neurite outgrowth and inhibits angiogenesis. Analysis of gain and loss of function experiments reveal that SPON1 is required for accurate pathfinding of embryonic axons, and plays a dual role in patterning axonal trajectories. It promotes the outgrowth of commissural and inhibits the outgrowth of motor axons, and has also been implicated in inflammatory processes in the nervous system.

Subunit:
Binds to the central extracellular domain of APP and inhibits beta-secretase cleavage of APP.

Subcellular Location:
Secreted, extracellular space, extracellular matrix.

Tissue Specificity:
Highest expression in lung, lower expression in brain, heart, kidney, liver and testis, and lowest expression in pancreas, skeletal muscle and ovary. Not expressed in spleen.

Similarity:
Contains 1 reelin domain.
Contains 1 spondin domain.
Contains 6 TSP type-1 domains.

Database links:
 

UniProtKB/Swiss-Prot: Q9HCB6.2

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.    

细胞外基质底物反应蛋白1抗

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