英文名称    SART3    

中文名称    T淋巴细胞识别的鳞状细胞癌SART3抗体    

别    名    p110(nrb); SART3; SART-3; Tat interacting protein of 110 kDa; TIP110; SART3_HUMAN.    

T淋巴细胞识别的鳞状细胞癌SART3抗体    

说 明 书    0.2ml  1ml    

研究领域    肿瘤  细菌及病毒  t-淋巴细胞  肿瘤细胞生物标志物  表观遗传学      

抗体来源    Rabbit    

克隆类型    Polyclonal    

交叉反应    Human, Mouse, Rat, Dog, Pig, Cow, Rabbit,     

产品应用    WB=1:100-500 ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.    

分 子 量    110kDa    

细胞定位    细胞核 细胞浆     

性    状    Lyophilized or Liquid    

浓    度    1mg/1ml    

免 疫 原    KLH conjugated synthetic peptide derived from human SART3    

亚    型    IgG    

纯化方法    affinity purified by Protein A    

储 存 液    Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4    

保存条件    Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.    

T淋巴细胞识别的鳞状细胞癌SART3抗体产品介绍    background:
RelevanceSART3 regulates Tat transactivation activity through direct interaction. It may be a cellular factor for HIV1 gene expression and viral replication.

Subunit:
Component of the 7SK snRNP complex at least composed of P-TEFb (composed of CDK9 and CCNT1/cyclin-T1), HEXIM1, HEXIM2, BCDIN3, SART3 proteins and 7SK and U6 snRNAs. Interacts with HIV-1 Tat. Interacts with EIF2C1 and EIF2C2.

Subcellular Location:
Cytoplasm. Nucleus speckle. Note=Localized in speckles. Expressed in the nucleus of all of the malignant tumor cell lines tested and the majority of cancer tissues with various histologies, including squamous cell carcinomas (SCC), adenocarcinomas, melanomas and leukemias cells. However, this protein is undetectable in the nucleus of any cell lines of nonmalignant cells or normal tissues, except for the testis. Expressed in the cytoplasm of all the proliferating cells, including normal and malignant cells, but not in normal tissues, except for the testis and the fetal liver.

Tissue Specificity:
Ubiquitously expressed.

Similarity:
Contains 8 HAT repeats. 
Contains 2 RRM (RNA recognition motif) domains.

Database links:
 

UniProtKB/Swiss-Prot: Q15020.1

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.    

T淋巴细胞识别的鳞状细胞癌SART3抗体

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