产品详情
英文名称 Selenium Binding Protein 1
中文名称 硒结合蛋白1抗体
别 名 SBP; SBP1; Selenbp2; Selenium binding protein 2; Selenium binding protein1; SELNBP1; SP56; 56 kDa selenium binding protein.
硒结合蛋白1抗体
说 明 书 0.2ml
研究领域 肿瘤 免疫学 神经生物学 信号转导
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse, Rat, Dog, Cow, Rabbit,
产品应用 WB=1:100-500 ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 (石蜡切片需做抗原修复)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 52kDa
细胞定位 细胞核 细胞浆 细胞膜
性 状 Lyophilized or Liquid
浓 度 1mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from human SBP1/Selenium Binding Protein 1
亚 型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
硒结合蛋白1抗体 产品介绍 background:
Selenium is an essential trace element that confers tolerance to toxicity arising through exposure to heavy metals or other reactive xenobiotics. Selenium exhibits potent anticarcinogenic properties, and deficiency of selenium may cause certain neurologic diseases. Both effects are attributed to selenium-binding proteins. Selenium binding protein 1 is down-regulated in lung adenocarcinoma, colorectal cander and ovarian cancer. It is two-fold upregulated in the brains of patients suffering from schizophrenia, and is therefore a biomarker for this disease.
Function:
Selenium-binding protein which may be involved in the sensing of reactive xenobiotics in the cytoplasm. May be involved in intra-Golgi protein transport.
Subunit:
Interacts with USP33.
Subcellular Location:
Nucleus. Cytoplasm, cytosol. Membrane; Peripheral membrane protein. Note=May associate with Golgi membrane. May associate with the membrane of autophagosomes.
Tissue Specificity:
Present in liver and colon (at protein level).
Post-translational modifications:
The N-terminus is blocked.
Similarity:
Belongs to the selenium-binding protein family.
Database links:
Entrez Gene: 8991 Human
Entrez Gene: 20341 Mouse
Entrez Gene: 140927 Rat
Omim: 604188 Human
SwissProt: Q13228 Human
SwissProt: P17563 Mouse
SwissProt: Q8VIF7 Rat
Unigene: 632460 Human
Unigene: 16617 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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