英文名称    SOD2    

中文名称    超氧化物歧化酶2抗体    

别    名    IPO B; Manganese SOD; Superoxide Dismutase 2; Manganese superoxide dismutase; Mn SOD; MNSOD; SOD 2; SOD-2; SOD2; Superoxide dismutase [Mn] mitochondrial; Superoxide dismutase [Mn] mitochondrial precursor; Superoxide dismutase 2 mitochondrial; SODM_HUMAN.    

超氧化物歧化酶2抗体 

说 明 书    0.1ml  0.2ml  1ml    

研究领域    神经生物学  细胞凋亡  激酶和磷酸酶  线粒体      

抗体来源    Rabbit    

克隆类型    Polyclonal    

交叉反应    Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, Sheep,     

产品应用    WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.    

分 子 量    22kDa    

细胞定位    细胞浆 线粒体    

性    状    Lyophilized or Liquid    

浓    度    1mg/1ml    

免 疫 原    KLH conjugated synthetic peptide derived from human SOD2    

亚    型    IgG    

纯化方法    affinity purified by Protein A    

储 存 液    0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide    

保存条件    Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.    

超氧化物歧化酶2抗体产品介绍    background:
This gene is a member of the iron/manganese superoxide dismutase family. It encodes a mitochondrial protein that forms a homotetramer and binds one manganese ion per subunit. This protein binds to the superoxide byproducts of oxidative phosphorylation and converts them to hydrogen peroxide and diatomic oxygen. Mutations in this gene have been associated with idiopathic cardiomyopathy (IDC), premature aging, sporadic motor neuron disease, and cancer. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]

Function:
Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems.

Subunit:
Homotetramer.

Subcellular Location:
Mitochondrion matrix.

Post-translational modifications:
Nitrated under oxidative stress. Nitration coupled with oxidation inhibits the catalytic activity. 
Acetylation at Lys-122 decreases enzymatic activity. Deacetylated by SIRT3 upon exposure to ionizing radiations or after long fasting.

DISEASE:
Microvascular complications of diabetes 6 (MVCD6) [MIM:612634]: Pathological conditions that develop in numerous tissues and organs as a consequence of diabetes mellitus. They include diabetic retinopathy, diabetic nephropathy leading to end-stage renal disease, and diabetic neuropathy. Diabetic retinopathy remains the major cause of new-onset blindness among diabetic adults. It is characterized by vascular permeability and increased tissue ischemia and angiogenesis. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.

Similarity:
Belongs to the iron/manganese superoxide dismutase family.

Gene ID:
6648

Database links:

Entrez Gene: 374042 Chicken

Entrez Gene: 281496 Cow

Entrez Gene: 476258 Dog

Entrez Gene: 6648 Human

Entrez Gene: 20656 Mouse

Entrez Gene: 100154319 Pig

Entrez Gene: 24787 Rat

Omim: 147460 Human

SwissProt: P41976 Cow

SwissProt: P04179 Human

SwissProt: P09671 Mouse

SwissProt: P41982 Rabbit

SwissProt: P07895 Rat

Unigene: 487046 Human

Unigene: 290876 Mouse

Unigene: 10488 Rat

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.     

超氧化物歧化酶2抗体

hz-0358M-PE-hzy3 Mouse Anti-Guinea pig IgG/PE-Cy3  PE-Cy3标记的小鼠抗豚鼠IgG

hz-0358M-PE-hzY5 Mouse Anti-Guinea pig IgG/PE-CY5  PE-CY5标记的小鼠抗豚鼠IgG

hz-0358M-FIThz Mouse Anti-Guinea pig IgG/FITC  FITC标记的小鼠抗豚鼠IgG

hz-0358M-RBIThz Mouse Anti-Guinea pig IgG/RBITC  罗丹明标记的小鼠抗豚鼠IgG

hz-0358M-AP Mouse Anti-Guinea pig IgG/AP  碱性磷酸酶（AP）标记的小鼠抗豚鼠IgG

hz-0358M-Bio Mouse Anti-Guinea pig IgG/Bio  生物素标记的小鼠抗豚鼠IgG

hz-0358M-Gold Mouse Anti-Guinea pig IgG/Gold  胶体金标记的小鼠抗豚鼠IgG

hz-0358M-HRP Mouse Anti-Guinea pig IgG/HRP  辣根过氧化物酶标记的小鼠抗豚鼠IgG

hz-0358M-APhz Mouse Anti-Guinea pig IgG/APC  APC标记的小鼠抗豚鼠IgG

hz-0358M-AF350 Mouse Anti-Guinea pig IgG/Alexa Fluor 350  Alexa Fluor 350标记的小鼠抗豚鼠IgG

hz-0358M-AF488 Mouse Anti-Guinea pig IgG/Alexa Fluor 488  Alexa Fluor 488标记的小鼠抗豚鼠IgG

hz-0358M-AF555 Mouse Anti-Guinea pig IgG/Alexa Fluor 555  Alexa Fluor 555标记的小鼠抗豚鼠IgG

hz-0358M-AF647 Mouse Anti-Guinea pig IgG/Alexa Fluor 647  Alexa Fluor 647标记的小鼠抗豚鼠IgG

hz-0358M-PE-hzy5.5 Mouse Anti-Guinea pig IgG/PE-Cy5.5  PE-Cy5.5标记的小鼠抗豚鼠IgG

hz-0358M-PE-hzy7 Mouse Anti-Guinea pig IgG/PE-Cy7  PE-Cy7标记的小鼠抗豚鼠IgG

hz-0312R-hzy3 Rabbit Anti-Avidin/Cy3  Cy3标记的兔抗亲和素

hz-0312R-hzy5 Rabbit Anti-Avidin/Cy5  Cy5标记的兔抗亲和素

hz-0312R-hzy5.5 Rabbit Anti-Avidin/Cy5.5  Cy5.5标记的兔抗亲和素

hz-0312R-Bio Rabbit Anti-Avidin/Bio  生物素标记的兔抗亲和素

hz-0312R-AP Rabbit Anti-Avidin/AP  碱性磷酸酶（AP）标记的兔抗亲和素

hz-0312R-HRP Rabbit Anti-Avidin/HRP  辣根过氧化物酶标记的兔抗亲和素

hz-0312R-hzy7 Rabbit Anti-Avidin/Cy7  Cy7标记的兔抗亲和素

hz-0312R-PE Rabbit Anti-Avidin/PE  PE标记的兔抗亲和素

hz-0312R-PE-hzy3 Rabbit Anti-Avidin/PE-Cy3  PE-Cy3标记的兔抗亲和素

hz-0312R-RBIThz Rabbit Anti-Avidin/RBITC  罗丹明标记的兔抗亲和素

hz-0312R-Gold Rabbit Anti-Avidin/Gold  胶体金标记的兔抗亲和素

hz-0312R-FIThz Rabbit Anti-Avidin/FITC  FITC标记的兔抗亲和素

hz-0312R-PE-hzY5 Rabbit Anti-Avidin/PE-CY5  PE-CY5标记的兔抗亲和素

hz-0312R-APhz Rabbit Anti-Avidin/APC  APC标记的兔抗亲和素

hz-0312R-AF350 Rabbit Anti-Avidin/Alexa Fluor 350  Alexa Fluor 350标记的兔抗亲和素