产品详情
英文名称 VGLL2
中文名称 转录辅助因子退变样蛋白2抗体
别 名 Protein VITO1; Transcription cofactor vestigial like 2; Transcription cofactor vestigial like protein 2; Transcription cofactor vestigial-like protein 2; Vestigial like 2; Vestigial like 2 (Drosophila); Vgl-2; VGL2; VGLL 2; Vgll2; VGLL2_HUMAN; VITO1.
转录辅助因子退变样蛋白2抗体
说 明 书 0.1ml 0.2ml
研究领域 肿瘤 细胞生物 免疫学 信号转导 干细胞 转录调节因子 表观遗传学
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse, Rat, Dog, Pig, Cow, Rabbit,
产品应用 WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:50-200 (石蜡切片需做抗原修复)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 33kDa
细胞定位 细胞核
性 状 Lyophilized or Liquid
浓 度 1mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from human VGLL2
亚 型 IgG
纯化方法 affinity purified by Protein A
储 存 液 Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
转录辅助因子退变样蛋白2抗体产品介绍 background:
Vgl-2, also known as VITO-1, is a 317 amino acid protein that contains a domain through which it interacts with TEF-1, a protein that plays a role in controlling the expression of numerous genes. Specific to skeletal muscle, Vgl-2 is expressed highly in adult fast muscle and is expressed at lower levels in adult slow muscle and fetal skeletal muscle. During muscle differentiation, Vgl-2 mRNA levels increase and Vgl-2 translocates from the cytoplasm to the nucleus. Overexpression of Vgl-2 in MYOD-transfected 10T1/2 mouse embryonic fibroblasts increases expression of myosin heavy chain (MHC), which is a marker of terminal muscle differentiation. This evidence suggests that Vgl-2 is essential for muscle gene expression. There are two isoforms of Vgl-2 that are produced as a result of alternative splicing events.
Function:
May act as a specific coactivator for the mammalian TEFs. May play a role in the development of skeletal muscles.
Subunit:
Interacts with TEFs. Binds to TEAD1/TEF1.
Subcellular Location:
Nucleus.
Tissue Specificity:
Skeletal muscle.
Similarity:
Belongs to the vestigial family.
Gene ID:
245806
Database links:
Entrez Gene: 245806 Human
Entrez Gene: 215031 Mouse
Omim: 609979 Human
SwissProt: Q8N8G2 Human
SwissProt: Q8BGW8 Mouse
Unigene: 99324 Human
Unigene: 87237 Mouse
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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