英文名称    Vitronectin    

中文名称    玻璃粘连蛋白抗体    

别    名    Vitronectin; Complement S Protein; Epibolin; S Protein; Serum Spreading Factor; V75; Vitronectin V10 subunit; VN; VNT; VTN; S-protein; Serum-spreading factor; V75; Vitronectin V10 subunit; VTNC_HUMAN.    

 玻璃粘连蛋白抗体        

说 明 书    0.1ml  0.2ml      

研究领域    心血管  免疫学      

抗体来源    Rabbit    

克隆类型    Polyclonal    

交叉反应    Human, Mouse, Rat, Dog, Cow,     

产品应用    WB=1:100-500 ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.    

分 子 量    9/52kDa    

细胞定位    细胞外基质 分泌型蛋白     

性    状    Lyophilized or Liquid    

浓    度    1mg/1ml    

免 疫 原    KLH conjugated synthetic peptide derived from human Vitronectin    

亚    型    IgG    

纯化方法    affinity purified by Protein A    

储 存 液    0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide    

保存条件    Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.    

 玻璃粘连蛋白抗体 产品介绍    background:
Vitronectin (also known as serum spreading factor, S protein of complement or epibolin) is one of the major multifunctional cell adhesive glycoproteins in mammalian plasma and serum. It is a monomeric acidic glycoprotein detected as a mixture of 75 kD and 65 kD polypeptides. Vitronectin binds to heparin, collagen, streptococci and variety of cultured cells. It also acts as an inhibitor of the complement cascade by binding to the C5b9 complex. Vitronectin promotes cell adhesion and spreading by binding through its cell attachment tripeptide Arg-Gly-Asp (RG-D), activity which is mediated by several different integrin receptors. Apart from the significance for identifying the molecule in the above situations, it also plays an important role in events such as embryonal development, deposition of vitronectin in a number of fibrotic disease states, carcinomas and metastases.

Function:
Vitronectin is a cell adhesion and spreading factor found in serum and tissues. Vitronectin interact with glycosaminoglycans and proteoglycans. Is recognized by certain members of the integrin family and serves as a cell-to-substrate adhesion molecule. Inhibitor of the membrane-damaging effect of the terminal cytolytic complement pathway (By similarity).

Subunit:
Monomer. Interacts with SERPINE1/PAI1 (By similarity).

Subcellular Location:
Secreted, extracellular space.

Tissue Specificity:
Plasma.

Post-translational modifications:
Sulfated on 2 tyrosine residues (By similarity). 
N- and O-glycosylated (By similarity). 
It has been suggested that the active SMB domain may be permitted considerable disulfide bond heterogeneity or variability, thus two alternate disulfide patterns based on 3D structures are described with 1 disulfide bond conserved in both.

Similarity:
Contains 4 hemopexin-like domains. 
Contains 1 SMB (somatomedin-B) domain.

Gene ID:
7448

Database links:

Entrez Gene: 7448 Human

Entrez Gene: 22370 Mouse

Entrez Gene: 29169 Rat

Omim: 193190 Human

SwissProt: P04004 Human

SwissProt: P29788 Mouse

Unigene: 2257 Human

Unigene: 3667 Mouse

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.    

 玻璃粘连蛋白抗体 

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hz-0345G-AF555 Goat Anti-human IgM/Alexa Fluor 555  Alexa Fluor 555标记的羊抗人IgM

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hz-0345G-PE-hzy5.5 Goat Anti-human IgM/PE-Cy5.5  PE-Cy5.5标记的羊抗人IgM

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hz-0345G-HRP Goat Anti-human IgM/HRP  辣根过氧化物酶标记的羊抗人IgM

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hz-0297M-PE-hzy7 Mouse Anti-human IgG/PE-Cy7  PE-Cy7标记的小鼠抗人IgG