英文名称    URP2/Kindlin-3    

中文名称    整合素结合性信号分子抗体    

别    名    Fermitin family homolog 3; Fermitin family member 3; FERMT3; Kind3; Kindlin 3; Kindlin-3; Kindlin3; MGC10966; MIG 2; MIG2 like protein; MIG2-like protein; MIG2B; Unc 112 related protein 2; Unc-112-related protein 2; UNC112C; URP2_HUMAN; URP2SF.    

整合素结合性信号分子抗体  

说 明 书    0.1ml  0.2ml      

研究领域    肿瘤  细胞生物  信号转导  细胞粘附分子      

抗体来源    Rabbit    

克隆类型    Polyclonal    

交叉反应    Human, Mouse, Rat, Pig, Cow, Horse,     

产品应用    WB=1:100-500 ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.    

分 子 量    76kDa    

细胞定位    细胞膜     

性    状    Lyophilized or Liquid    

浓    度    1mg/1ml    

免 疫 原    KLH conjugated synthetic peptide derived from human URP2    

亚    型    IgG    

纯化方法    affinity purified by Protein A    

储 存 液    Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4    

保存条件    Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.    

整合素结合性信号分子抗体 产品介绍    background:
Kindlin-3 is a 667 amino acid protein that localizes to both the cell membrane and the cytoplasm and contains one PH domain and one FERM domain. Expressed at high levels in lymph node tissue and at lower levels in spleen, thymus, stomach, placenta, lung, testis and small intestine, Kindlin-3 is thought to be involved in cell adhesion events and may play a role in apoptosis. Kindlin-3 is overexpressed in B-cell malignancies, suggesting that, via its ability to affect cell adhesion, Kindlin-3 may participate in tumor transformation and metastasis. Two isforms of Kindlin-3, designated short and long, exist due to alternative splicing events.

Function:
Plays a central role in cell adhesion in hematopoietic cells. Acts by activating the integrin beta-1-3 (ITGB1, ITGB2 and ITGB3). Required for integrin-mediated platelet adhesion and leukocyte adhesion to endothelial cells. Required for activation of integrin beta-2 (ITGB2) in polymorphonuclear granulocytes (PMNs).
Isoform 2 may act as a repressor of NF-kappa-B and apoptosis.

Subcellular Location:
Cell projection; podosome. Present in the F-actin surrounding ring structure of podosomes, which are specialized adhesion structures of hematopoietic cells.

Tissue Specificity:
Highly expressed in lymph node. Expressed in thymus, spleen and leukocytes. Weakly expressed in placenta, small intestine, stomach, testis and lung. Overexpressed in B-cell malignancies.

DISEASE:
Defects in FERMT3 are the cause of leukocyte adhesion deficiency type 3 (LAD3) [MIM:612840]; also called leukocyte adhesion deficiency 1 variant (LAD1v). LAD3 is a rare syndrome characterized by infections without pus formation in the presence of a leukocytosis combined with a Glanzmann-type bleeding disorder, resulting from a hematopoietic defect in integrin activation. Symptoms arise from an inability to activate the integrins expressed on hematopoietic cells, including platelets and leukocytes.

Similarity:
Belongs to the kindlin family.
Contains 1 FERM domain.
Contains 1 PH domain.

Gene ID:
83706

Database links:

Entrez Gene: 83706 Human

Entrez Gene: 525159 Cow

Entrez Gene: 108101 Mouse

Entrez Gene: 309186 Rat

Omim: 607901 Human

SwissProt: Q32LP0 Cow

SwissProt: Q86UX7 Human

SwissProt: Q8K1B8 Mouse

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.    

整合素结合性信号分子抗体 

hz-0294R-PE-hzy3 Rabbit Anti-Goat IgG/PE-Cy3  PE-Cy3标记的兔抗羊IgG

hz-0294R-AF350 Rabbit Anti-Goat IgG/Alexa Fluor 350  Alexa Fluor 350标记的兔抗羊IgG

hz-0294R-AF488 Rabbit Anti-Goat IgG/Alexa Fluor 488  Alexa Fluor 488标记的兔抗羊IgG

hz-0294R-AF555 Rabbit Anti-Goat IgG/Alexa Fluor 555  Alexa Fluor 555标记的兔抗羊IgG

hz-0294R-AF647 Rabbit Anti-Goat IgG/Alexa Fluor 647  Alexa Fluor 647标记的兔抗羊IgG

hz-0294R-PE-hzy5.5 Rabbit Anti-Goat IgG/PE-Cy5.5  PE-Cy5.5标记的兔抗羊IgG

hz-0294R-PE-hzy7 Rabbit Anti-Goat IgG/PE-Cy7  PE-Cy7标记的兔抗羊IgG

hz-0294R-Gold Rabbit Anti-Goat IgG/Gold  胶体金标记的兔抗羊IgG

hz-0294R-HRP Rabbit Anti-Goat IgG/HRP  辣根过氧化物酶标记的兔抗羊IgG

hz-0294R-RBIThz Rabbit Anti-Goat IgG/RBITC  罗丹明标记的兔抗羊IgG

hz-0294R-Bio Rabbit Anti-Goat IgG/Bio  生物素标记的兔抗羊IgG

hz-0370R-HRP Rabbit Anti-Goat IgM/HRP  辣根过氧化物酶标记的兔抗羊IgM

hz-0370R-Bio Rabbit Anti-Goat IgM/Bio  生物素标记的兔抗羊IgM

hz-0370R-AP Rabbit Anti-Goat IgM/AP  碱性磷酸酶（AP）标记的兔抗羊IgM

hz-0370R-Gold Rabbit Anti-Goat IgM/Gold  胶体金标记的兔抗羊IgM

hz-0370R-hzy3 Rabbit Anti-Goat IgM/Cy3  Cy3标记的兔抗羊IgM

hz-0370R-hzy5 Rabbit Anti-Goat IgM/Cy5  Cy5标记的兔抗羊IgM

hz-0370R-hzy5.5 Rabbit Anti-Goat IgM/Cy5.5  Cy5.5标记的兔抗羊IgM

hz-0370R-hzy7 Rabbit Anti-Goat IgM/Cy7  Cy7标记的兔抗羊IgM

hz-0370R-PE Rabbit Anti-Goat IgM/PE  PE标记的兔抗羊IgM

hz-0370R-PE-hzy3 Rabbit Anti-Goat IgM/PE-Cy3  PE-Cy3标记的兔抗羊IgM

hz-0370R-PE-hzY5 Rabbit Anti-Goat IgM/PE-CY5  PE-CY5标记的兔抗羊IgM

hz-0370R-APhz Rabbit Anti-Goat IgM/APC  APC标记的兔抗羊IgM

hz-0370R-AF350 Rabbit Anti-Goat IgM/Alexa Fluor 350  Alexa Fluor 350标记的兔抗羊IgM

hz-0370R-AF488 Rabbit Anti-Goat IgM/Alexa Fluor 488  Alexa Fluor 488标记的兔抗羊IgM

hz-0370R-AF555 Rabbit Anti-Goat IgM/Alexa Fluor 555  Alexa Fluor 555标记的兔抗羊IgM

hz-0370R-AF647 Rabbit Anti-Goat IgM/Alexa Fluor 647  Alexa Fluor 647标记的兔抗羊IgM

hz-0370R-PE-hzy5.5 Rabbit Anti-Goat IgM/PE-Cy5.5  PE-Cy5.5标记的兔抗羊IgM

hz-0370R-PE-hzy7 Rabbit Anti-Goat IgM/PE-Cy7  PE-Cy7标记的兔抗羊IgM

hz-0370R-RBIThz Rabbit Anti-Goat IgM/RBITC  罗丹明标记的兔抗羊IgM

hz-0370R-FIThz Rabbit Anti-Goat IgM/FITC  FITC标记的兔抗羊IgM

hz-0358R-FIThz Rabbit Anti-Guinea pig IgG/FITC  FITC标记的兔抗豚鼠IgG

hz-0358R-AF555 Rabbit Anti-Guinea pig IgG/Alexa Fluor 555  Alexa Fluor 555标记的兔抗豚鼠IgG

hz-0358R-AF647 Rabbit Anti-Guinea pig IgG/Alexa Fluor 647  Alexa Fluor 647标记的兔抗豚鼠IgG

hz-0358R-PE-hzy5.5 Rabbit Anti-Guinea pig IgG/PE-Cy5.5  PE-Cy5.5标记的兔抗豚鼠IgG

hz-0358R-PE-hzy7 Rabbit Anti-Guinea pig IgG/PE-Cy7  PE-Cy7标记的兔抗豚鼠IgG