英文名称    VPAC2R    

中文名称    腺苷酸环化酶激活肽受体-II/血管活性肠肽受体-II抗体    

别    名    VIP receptor II; VIP receptor2; VIP receptor-2; PACAP type-3; VIP type-2 receptor; Vipr2; Vip2; VPAC2; VPAC2R; Vasoactive intestinal polypeptide receptor 2; VIP-R-2; Pituitary adenylate cyclase-activating polypeptide type III receptor; PACAP type III receptor; PACAP-R-3; PACAP-R3; VIPR2_HUMAN.    

腺苷酸环化酶激活肽受体-II/血管活性肠肽受体-II抗体

说 明 书    0.1ml  0.2ml      

研究领域    细胞生物  免疫学  神经生物学  信号转导  生长因子和激素  细胞膜受体  G蛋白偶联受体      

抗体来源    Rabbit    

克隆类型    Polyclonal    

交叉反应    Human, Mouse, Rat, Rabbit,     

产品应用    WB=1:100-500 ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 Flow-Cyt=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.    

分 子 量    48kDa    

细胞定位    细胞膜     

性    状    Lyophilized or Liquid    

浓    度    1mg/1ml    

免 疫 原    KLH conjugated synthetic peptide derived from human VIP receptor II    

亚    型    IgG    

纯化方法    affinity purified by Protein A    

储 存 液    0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide    

保存条件    Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.    

腺苷酸环化酶激活肽受体-II/血管活性肠肽受体-II抗体产品介绍    background:
Pituitary adenylate cyclase-activating polypeptide (PACAP) is a neuropeptide belonging to the vasoactive intestinal polypeptide/glucagon/ secretin family. It is widely distributed in the body, and a variety of biological actions have been reported. Recent studies have shown that there is a family of PACAP receptors (PACAPRs), and two members of this family have been identified. Mouse PACAPR-3 is a protein of 437 amino acids that has 50% and 51% identity with rat PACAP type I and type II receptors, respectively. It binds to vasoactive intestinal polypeptide as well as PACAP-38 and -27, with a slightly higher affinity for PACAP-38, PACAPR-3 mRNA is expressed at high levels in MIN6, at moderate levels in pancreatic islets and other insulin-secreting cell lines, HIT-T15 and RINm5F, as well as in the lung, brain, stomach, and colon, and at low levels in the heart. PACAPR-3 participates in the regulation of insulin secretion. insulin secretion from MIN6 cells is significantly stimulated by PACAP-38.

Function:
This is a receptor for VIP as well as PACAP-38 and -27, the activity of this receptor is mediated by G proteins which activate adenylyl cyclase. Can be coupled to phospholipase C.

Subcellular Location:
Cell membrane; Multi-pass membrane protein.

Tissue Specificity:
Expressed in CD4+ T-cells, but not in CD8+ T-cells. Expressed in the T-cell lines Jurkat, PEER, MOLT-4, HSB, YT and Tsup-1, but not in the T-cell lines HARRIS and HUT 78.

Similarity:
Belongs to the G-protein coupled receptor 2 family.

Gene ID:
7434

Database links:

Entrez Gene: 7434 Human

Omim: 601970 Human

SwissProt: P41587 Human

Unigene: 585052 Human

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.     

腺苷酸环化酶激活肽受体-II/血管活性肠肽受体-II抗体

hzm-0297M-AF647 Mouse Anti-human IgG(3D3)/Alexa Fluor 647  Alexa Fluor 647标记的鼠抗人IgG单克隆抗体

hzm-0297M-PE-hzy5.5 Mouse Anti-human IgG(3D3)/PE-Cy5.5  PE-Cy5.5标记的鼠抗人IgG单克隆抗体

hzm-0297M-PE-hzy7 Mouse Anti-human IgG(3D3)/PE-Cy7  PE-Cy7标记的鼠抗人IgG单克隆抗体

hzm-0297M-HRP Mouse Anti-human IgG(3D3)/HRP  辣根过氧化物酶标记的鼠抗人IgG单克隆抗体

hzm-0297M-AP Mouse Anti-human IgG(3D3)/AP  碱性磷酸酶（AP）标记的鼠抗人IgG单克隆抗体

hzm-0297M-Bio Mouse Anti-human IgG(3D3)/Bio  生物素标记的鼠抗人IgG单克隆抗体

五、蛋白质与多肽

编  号 名  称

hz-0292P BSA (bovine serum albumin)  牛血清白蛋白（第五组分）

hz-0225P KLH (keyhole limpet hhzocyanin)  血蓝蛋白

hz-0283P OVA (ovalbumin)  鸡卵白蛋白

hz-0291P THY (thyroglobulin,TG)  甲状腺球蛋白

hz-0945P HSA/human Serum albumin  人血清白蛋白

hz-1240P Hu Fibrinogen  人纤维蛋白原

hz-0437P Streptavidin, SA  链霉亲和素

PH-2 Protein G/FITC  FITC标记蛋白-G

hz-0362P Protein A  蛋白A

hz-0883P GST-Tag protein  重组谷胱甘肽-转移酶

hzsl-hz8280 Cholesterol  胆固醇

hz-0104P Beta-Amyloid(1-16)  β淀粉样肽1-16（多肽蛋白）

hz-0871P Beta-Amyloid (31-35)  β淀粉样肽31-35（多肽蛋白）

hz-0105P Beta-Amyloid(1-28)  β淀粉样肽1-28（多肽蛋白）

hz-0106P Beta-Amyloid(1-40)  β淀粉样肽（1-40）（多肽蛋白）

Y-0113 A Beta1-40 (mutation type, MT) peptide  突变型β淀粉样肽1-40

Y-0114 A Beta1-40 (H-3-me6;H-3-me13;H-3-me14; Beta-Amyloid 1-40)  β淀粉样肽1-40（结构改造）

Y-0120 A Beta29-40( Beta-Amyloid 29-40)  β淀粉样肽29-40(野生型)

Y-0121 A Beta29-42( Beta-Amyloid 29-42)  β淀粉样肽29-42(野生型)

hz-0107P Beta-Amyloid (1-42)  β淀粉样肽（1-42）

Y-0044 Amyloid Beta 25-35( Beta-Amyloid 25-35)  β淀粉样肽25-35（多肽）

hz-0076P Beta-Amyloid 1-42 CT  β淀粉样肽 1-42 (C端多肽)

hz-0057P Amylin  糖尿病相关肽（胰岛淀粉样肽）

hz-0112P APP695-770 (Amyloid protein precursor)  淀粉样肽前体蛋白（多肽抗原）

hz-0499P Neuroprotective peptide/Gly-HN(Nuclear-encoded Humanin [HN(N)] Gly14)  神经保护肽

Y-0158 Amylin(1-37) amide  糖尿病相关肽/胰岛淀粉样肽

hz-1053P CCP peptide (cyclic citrullinated peptide,CCP)   瓜氨酸环肽

hz-0616P CCP peptide (cyclic citrullinated peptide,CCP)  瓜氨酸环肽

hz-4536P Streptococcus suis 2 (Cell protein)  2型猪链球菌菌体蛋白