产品详情
英文名称 TCTN1
中文名称 结构蛋白家族1抗体
别 名 TCTN1; TECT1_HUMAN; Tectonic-1.
结构蛋白家族1抗体
说 明 书 0.2ml
研究领域 细胞生物 免疫学 神经生物学
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse, Rat, Pig, Cow, Sheep,
产品应用 WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 (石蜡切片需做抗原修复)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 61kDa
细胞定位 分泌型蛋白
性 状 Lyophilized or Liquid
浓 度 1mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from human TCTN1
亚 型 IgG
纯化方法 affinity purified by Protein A
储 存 液 Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
结构蛋白家族1抗体 产品介绍 background:
Regulator of Hedgehog (Hh), required for both activation and inhibition of the Hh pathway in the patterning of the neural tube. During neural tube development, it is required for formation of the most ventral cell types and for full Hh pathway activation. Functions in Hh signal transduction to fully activate the pathway in the presence of high Hh levels and to repress the pathway in the absence of Hh signals. Modulates Hh signal transduction downstream of SMO and RAB23.
Function:
Component of the tectonic-like complex, a complex localized at the transition zone of primary cilia and acting as a barrier that prevents diffusion of transmembrane proteins between the cilia and plasma membranes. Regulator of Hedgehog (Hh), required for both activation and inhibition of the Hh pathway in the patterning of the neural tube. During neural tube development, it is required for formation of the most ventral cell types and for full Hh pathway activation. Functions in Hh signal transduction to fully activate the pathway in the presence of high Hh levels and to repress the pathway in the absence of Hh signals. Modulates Hh signal transduction downstream of SMO and RAB23 (By similarity).
Subunit:
Part of the tectonic-like complex (also named B9 complex) (By similarity).
Subcellular Location:
Secreted.
DISEASE:
Defects in TCTN1 are the cause of Joubert syndrome type 13 (JBTS13) [MIM:614173]. JBTS13 is a disorder presenting with cerebellar ataxia, oculomotor apraxia, hypotonia, neonatal breathing abnormalities and psychomotor delay. Neuroradiologically, it is characterized by cerebellar vermian hypoplasia/aplasia, thickened and reoriented superior cerebellar peduncles, and an abnormally large interpeduncular fossa, giving the appearance of a molar tooth on transaxial slices (molar tooth sign). Additional variable features include retinal dystrophy and renal disease.
Similarity:
Belongs to the tectonic family.
Gene ID:
79600
Database links:
Entrez Gene: 79600 Human
Entrez Gene: 654470 Mouse
Omim: 609863 Human
SwissProt: Q2MV58 Human
SwissProt: Q8BZ64 Mouse
Unigene: 211511 Human
Unigene: 375934 Mouse
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
结构蛋白家族1抗体
hz-6477R FAS/Apo-1/CD95 载脂蛋白1抗体
hz-6478R CPE 胰羧肽酶E抗体
hz-6479R Myotilin 肌收缩蛋白MYOT抗体
hz-6499R PMCA 细胞膜钙转运ATP酶抗体
hz-6500R GABRA3/GABA A Receptor alpha 3 G氨基丁酸受体α3抗体
hz-5162R NChz/AADACL1 中性胆固醇酯水解酶1抗体
hz-6501R Rab25 癌基因RAS相关蛋白Rab25抗体
hz-6502R Testis 肿瘤抑制基因Testin抗体
hz-6503R ZNF288/ZBTB20 锌指蛋白288抗体
hz-6505R ALOX15/15 Lipoxygenase 1 花生四烯酸15脂氧合酶1抗体
hz-6506R ABI3BP ABI基因家族成员3结合蛋白抗体
hz-6507R MTCBP1/ADI1 膜型基质金属蛋白酶胞质尾结合蛋白1抗体
hz-6508R BCMP11/AGR3 乳腺癌膜蛋白11抗体(前梯度同源蛋白2)
hz-6509R ALDH1A1 胞质乙醛脱氢酶1抗体
hz-6510R ABH8/ALKBH8 AlkB同源蛋白8抗体
hz-6511R AMFR/Gp78/RNF45 环指蛋白45/自分泌运动因子受体抗体
hz-6512R AMBP/Alpha 1 microglobulin α1微球蛋白抗体
hz-6513R A2BP1/Fox1 共济失调蛋白2结合蛋白1抗体
hz-6514R RLLM1/C14orf166 胰腺癌转移相关蛋白RLLM1抗体
hz-6515R ABC2/C17orf71 乳腺癌增强蛋白2抗体
hz-6516R CA8 碳酸酐酶相关蛋白8抗体
hz-6517R CACNB1 钙通道电压依赖性β1蛋白抗体
hz-6518R CDK5RAP3 周期素依赖性激酶5激活结合蛋白C53抗体
hz-6519R CENPH 着丝粒蛋白H抗体
hz-6520R CKAP4 细胞骨架相关蛋白4抗体
hz-6521R CRISP3 富含半胱氨酸分泌蛋白3抗体
hz-6522R CKMT/Creatine kinase MT 酸性型线粒体肌酸激酶抗体
hz-6523R SCRO/DCUN1D1 鳞状细胞癌相关蛋白抗体
hz-6524R DDX53/CT26 肿瘤/睾丸抗原26抗体
hz-6525R DEPDC1 细胞周期调控蛋白SDP35抗体
hz-6526R ENTPD5/CD39L4 原癌基因CD39样蛋白4抗体
hz-6527R EST1A 端粒酶结合蛋白EST1A抗体
hz-6528R EZH1/Histone-lysine N-methyltransferase EZH1 组蛋白赖氨酸N-甲基EZH1抗体
hz-6529R phospho-KMT6/EZH2(Thr487) 磷酸化抑癌蛋白EZH2抗体
hz-6531R SKALP/Elafin 弹性蛋白酶抑制剂抗体
hz-6532R Epsti1/Epithelial Stromal Interaction 1 上皮间质相互作用蛋白1抗体