产品详情
英文名称 TTBK2
中文名称 Tau微管蛋白激酶2抗体
别 名 TTBK2/SCA11 Tau tubulin kinase 2; Spinocerebellar ataxia 11; Tau tubulin kinase 2; Tau-tubulin kinase 2; TTBK; TTBK 2; TTBK1; TTBK2; TTBK2_HUMAN; TTK; KIAA0847; mKIAA0847; SCA11.
Tau微管蛋白激酶2抗体
说 明 书 0.1ml 0.2ml
研究领域 神经生物学 信号转导 激酶和磷酸酶 细胞骨架 细胞外基质
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse, Rabbit,
产品应用 WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 (石蜡切片需做抗原修复)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 137kDa
性 状 Lyophilized or Liquid
浓 度 1mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from human TTBK2/SCA11 (1201-1300aa)
亚 型 IgG
纯化方法 affinity purified by Protein A
储 存 液 Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Tau微管蛋白激酶2抗体 产品介绍 background:
This gene encodes a serine-threonine kinase that putatively phosphorylates tau and tubulin proteins. Mutations in this gene cause spinocerebellar ataxia type 11 (SCA11); a neurodegenerative disease characterized by progressive ataxia and atrophy of the cerebellum and brainstem. [provided by RefSeq, Aug 2009].
Function:
Serine/threonine kinase which is able to phosphorylate tau on serines.
Subunit:
Interacts with CEP164.
DISEASE:
Defects in TTBK2 are the cause of spinocerebellar ataxia type 11 (SCA11) [MIM:604432]. Spinocerebellar ataxia is a clinically and genetically heterogeneous group of cerebellar disorders. Patients show progressive incoordination of gait and often poor coordination of hands, speech and eye movements, due to degeneration of the cerebellum with variable involvement of the brainstem and spinal cord. SCA11 is an autosomal dominant cerebellar ataxia (ADCA). It is a relatively benign, late-onset, slowly progressive neurologic disorder.
Similarity:
Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family.
Contains 1 protein kinase domain.
Database links:
Entrez Gene: 146057 Human
Omim: 611695 Human
SwissProt: Q6IQ55 Human
Unigene: 646511 Human
Unigene: 727864 Human
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
Tau微管蛋白激酶2抗体
hz-7933R PPP2R3A 蛋白质磷酸酶2调节亚基3A抗体
hz-7934R SHOC2/Sur8 富含亮氨酸重复蛋白SHOC2抗体
hz-7935R RAMP/CDT2 维甲酸调节核基质相关蛋白
hz-7936R MTMR8 肌管素相关蛋白8抗体
hz-7937R NIFK KI67相互作用蛋白抗体
hz-7938R phospho-NIFK/MKI67IP(Thr234) 磷酸化KI67相互作用蛋白抗体
hz-7939R TACC1 乳腺癌、胃癌抗原GA55抗体
hz-7941R ABCF3 三磷酸腺苷结合盒转运蛋白F亚基3抗体
hz-7942R ABHD1 肺α/β水解酶蛋白1抗体
hz-7943R ABHD13 水解酶结构域蛋白13抗体
hz-7945R ABHD14B 水解酶结构域蛋白14B抗体
hz-7946R ABHD15 水解酶结构域蛋白15抗体
hz-7947R ABHD3 肺α/β水解酶蛋白3抗体
hz-7948R ABHD4 α/β水解酶4抗体
hz-7950R ACBD4 酰基辅酶A结合结构域蛋白4抗体
hz-7951R ADCK1 ADCK1蛋白抗体
hz-7952R ADCK2 ADCK2蛋白抗体
hz-7953R AKR1A1 乙醇脱氢酶1抗体
hz-7954R ALAD δ氨基乙酰丙酸脱水酶抗体
hz-7955R TPTE 肿瘤/睾丸抗原44抗体
hz-7956R ALDH16A1 乙醛脱氢酶16家庭A1抗体
hz-7957R ALG11 天门冬酰胺连接糖基化11抗体
hz-7958R ALS2CR4 肌萎缩侧索硬化症相关蛋白4抗体
hz-7959R AMIGO3 粘附分子IgG样结构域蛋白3抗体
hz-7960R AMN1 细胞核重定位及纺锤体检查点蛋白AMN1抗体
hz-7961R ANKRD11 锚蛋白重复结构域蛋白11抗体
hz-7962R ANKRD12 锚蛋白重复结构域蛋白12抗体
hz-7963R ANKRD13A 锚蛋白重复结构域蛋白13A抗体
hz-7964R ANKRD9 锚蛋白重复结构域蛋白9抗体
hz-7965R APM2 脂肪特定转录因子2抗体
hz-7966R ANKS1A 锚蛋白重复及SAM结构域蛋白1A抗体
hz-7967R APOL3 载脂蛋白L3抗体
hz-7969R ARMC3 (Cancer/testis antigen 81) 肿瘤/睾丸抗原81抗体
hz-7970R ARS2 砷酸盐耐药蛋白ARS2抗体