产品详情
英文名称 TCN2
中文名称 转钴胺素蛋白2抗体
别 名 Macrocytic anemia; TC; TC II; TC-2; TC2; TCII; TCN 2; TCO2_HUMAN; Transcobalamin 2; Transcobalamin II; Transcobalamin II; macrocytic anemia; Transcobalamin-2; Vitamin B12 binding protein 2.
转钴胺素蛋白2抗体
说 明 书 0.1ml 0.2ml
研究领域 肿瘤 心血管 信号转导
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse, Rat, Rabbit,
产品应用 WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:50-200 (石蜡切片需做抗原修复)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 46kDa
细胞定位 分泌型蛋白
性 状 Lyophilized or Liquid
浓 度 1mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from human TCN2/Transcobalamin II
亚 型 IgG
纯化方法 affinity purified by Protein A
储 存 液 Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
转钴胺素蛋白2抗体 产品介绍 background:
Transcobalamin I (TCI) and Transcobalamin II (TCII) are secreted proteins belonging to the eukaryotic cobalamin transport proteins family and also to the vitamin B12-binding protein family. The genes encoding these proteins map to chromosome 11q11-q12 and 22q12.2, respectively. Transcobalamin I is a constituent of secondary granules in neutrophils, while Transcobalamin II binds cobalamin and mediates its transport into cells. These plasma proteins are expressed in various tissues and secretions.
Function:
Primary vitamin B12-binding and transport protein. Delivers cobalamin to cells.
Subcellular Location:
Secreted.
DISEASE:
Defects in TCN2 are the cause of transcobalamin II deficiency (TCN2 deficiency) [MIM:275350]. This results in various forms of anemia.
Similarity:
Belongs to the eukaryotic cobalamin transport proteins family.
Database links:
Entrez Gene: 6948 Human
Omim: 275350 Human
SwissProt: 275350 Human
SwissProt: P20062 Human
Unigene: 417948 Human
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
Involvement in disease;Defects in TCN2 are the cause of transcobalamin II deficiency (TCN2 deficiency) [MIM:275350]. This results in various forms of anemia.
转钴胺素蛋白2抗体
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hz-2589R P450 1A2/CYP1A2 细胞色素P450 1A2抗体
hz-3608R CYP11A1/P450SCC 细胞色素P450 11A1抗体
hz-2887R CYP2C9 细胞色素P450 2C9抗体
hz-3898R CYP11B1 细胞色素P450 11B1抗体
hz-4108R Cytochrome P450 2D1 细胞色素CYP2D1抗体
hz-1742R CYP3A4 细胞色素P450 3A4抗体
hz-2375R CYP3A1 细胞色素P450 3A1抗体
hz-5054R CYP4A1 细胞色素P450 4A1抗体
hz-4019R CYP5A1/Thromboxane synthase 血栓素合成酶抗体
hz-5055R CYP4A22 细胞色素P4504A22抗体(脂肪酸Ω羟化酶)
hz-2399R CYP7A1 细胞色素P450 7A1抗体/胆固醇7a羟化酶
hz-2991R CYP2D6 细胞色素P450 2D6抗体
hz-2352R Cytochrome P450 2B6 细胞色素P450 2B6抗体
hz-3853R CYP17 细胞色素P450 17抗体
hz-1292R CYP19/CYP19A1 细胞色素P450 19抗体
hz-5052R CYP7B1 胆固醇25α7羟化酶抗体
hz-3677R CYP8A1/PTGIS 前列环素合成酶抗体
hz-2443R CYP21 胆固醇21-羟化酶抗体
hz-2795R CYP2C19 细胞色素P450 2C19抗体
hz-3899R CYP24A1 细胞色素P450 24A1抗体
hz-5049R CYP27A1 胆固醇27α羟化酶抗体
hz-0461R CYP450 细胞色素P450单氧化酶抗体
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hz-1725R CYP2E1 细胞色素P450ⅡE1抗体
hz-4562R CYP2E1 细胞色素P450ⅡE1抗体
hz-3900R CYP2R1 细胞色素P450 2R1抗体
hz-5046R CYP46 胆固醇24S-羟化酶
hz-5050R CYP39A1 胆固醇24α7羟化酶抗体
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