英文名称    Gamma-taxilin    

中文名称    脂多糖相关反应蛋白5/γ-taxilin抗体    

别    名    chromosome X open reading frame 15; LSR5; CXorf15; Environmental lipopolysaccharide-responding gene protein; factor inhibiting activating transcription factor 4 (ATF4)-mediated transcription; Factor inhibiting ATF4-mediated transcription antibody FIAT; Gamma-taxilin; Lipopolysaccharide-specific response protein 5; LSR5; TXLNG; TXLNG_HUMAN.    

脂多糖相关反应蛋白5/γ-taxilin抗体        

说 明 书    0.2ml      

研究领域    细胞生物  干细胞  转录调节因子  表观遗传学      

抗体来源    Rabbit    

克隆类型    Polyclonal    

交叉反应    Human, Mouse,     

产品应用    WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:50-200 （石蜡切片需做抗原修复） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.    

分 子 量    60kDa    

细胞定位    细胞核 细胞浆 细胞膜     

性    状    Lyophilized or Liquid    

浓    度    1mg/1ml    

免 疫 原    KLH conjugated synthetic peptide derived from human Gamma-taxilin    

亚    型    IgG    

纯化方法    affinity purified by Protein A    

储 存 液    Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4    

保存条件    Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.    

脂多糖相关反应蛋白5/γ-taxilin抗体产品介绍    background:
This gene encodes a member of the taxilin family. The encoded protein binds to the C-terminal coiled-coil region of syntaxin family members 1A, 3A and 4A, and may play a role in intracellular vesicle trafficking. This gene is up-regulated by lipopolysaccharide and the gene product may be involved in cell cycle regulation. The related mouse protein was also shown to inhibit activating transcription factor 4-mediated transcription and thus regulate bone mass accrual. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2009].

Function:
May be involved in intracellular vesicle traffic. Inhibits ATF4-mediated transcription, possibly by dimerizing with ATF4 to form inactive dimers that cannot bind DNA. May be involved in regulating bone mass density through an ATF4-dependent pathway. May be involved in cell cycle progression.

Subunit:
Binds to the C-terminal coiled coil region of syntaxin family members STX1A, STX3A and STX4A. Forms a heterodimer with ATF4 in osteoblasts.

Subcellular Location:
Nucleus membrane. Cytoplasm, cytosol.

Tissue Specificity:
Ubiquitously expressed. Expressed at high level in heart and skeletal muscle. Expressed in brain, placenta, lung, liver, kidney and pancreas.

Similarity:
Belongs to the taxilin family.

Database links:

Entrez Gene: 353170 Mouse

SwissProt: Q8BHN1 Mouse

Unigene: 270186 Mouse

Unigene: 371732 Mouse

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.    

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