产品详情
英文名称 TBCD4
中文名称 TBC结构域TBCD4蛋白抗体
别 名 Acrg embryonic lethality (mouse) minimal region ortholog; Acrg embryonic lethality minimal region ortholog; Acrg embryonic lethality mouse minimal region ortholog; Akt substrate of 160 kDa; AS 160; AS160; TBC (Tre 2 BUB2 CDC16) domain containing protein; TBC Tre 2 BUB2 CDC16 domain containing protein; TBC1 D4; TBC1 domain family member 4; Tbc1d4; TBCD4_HUMAN.
TBC结构域TBCD4蛋白抗体
说 明 书 0.2ml
研究领域 免疫学 信号转导 转录调节因子 G蛋白偶联受体
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse, Rat, Pig, Cow, Sheep,
产品应用 WB=1:100-500 ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 (石蜡切片需做抗原修复)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 167kDa
性 状 Lyophilized or Liquid
浓 度 1mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from human TBCD4/TBC1D4
亚 型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
TBC结构域TBCD4蛋白抗体 产品介绍 background:
May act as a GTPase-activating protein for RAB2A, RAB8A, RAB10 and RAB14. Isoform 2 promotes insulin-induced glucose transporter SLC2A4/GLUT4 translocation at the plasma membrane, thus increasing glucose uptake.
Function:
May act as a GTPase-activating protein for RAB2A, RAB8A, RAB10 and RAB14. Isoform 2 promotes insulin-induced glucose transporter SLC2A4/GLUT4 translocation at the plasma membrane, thus increasing glucose uptake.
Subunit:
Cytoplasm. Note=Isoform 2 shows a cytoplasmic perinuclear localization in a myoblastic cell line in resting and insulin-stimulated cells.
Tissue Specificity:
Widely expressed. Isoform 2 is the highest overexpressed in most tissues. Isoform 1 is highly expressed in skeletal muscle and heart, but was not detectable in the liver nor in adipose tissue. Isoform 2 is strongly expressed in adrenal and thyroid gland, and also in lung, kidney, colon, brain and adipose tissue. Isoform 2 is moderately expressed in skeletal muscle. Expressed in pancreatic Langerhans islets, including beta cells (at protein level). Expression is decreased by twofold in pancreatic islets in type 2 diabetes patients compared to control subjects. Up-regulated in T-cells from patients with atopic dermatitis.
Post-translational modifications:
Phosphorylated by AKT1; insulin-induced. Also phosphorylated by AMPK in response to insulin. Insulin-stimulated phosphorylation is required for SLC2A4/GLUT4 translocation. Has no effect on SLC2A4/GLUT4 internalization. Physiological hyperinsulinemia increases phosphorylation in skeletal muscle. Insulin-stimulated phosphorylation is reduced by 39% in type 2 diabetic patients.
Similarity:
Contains 2 PID domains.
Contains 1 Rab-GAP TBC domain.
Database links:
UniProtKB/Swiss-Prot: O60343.2
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
TBC结构域TBCD4蛋白抗体
hz-8054R KLHL10 Kelch样蛋白10抗体
hz-8055R KLHL11 Kelch样蛋白11抗体
hz-8056R KLHL14 Kelch样蛋白14抗体
hz-8057R KLHL31 Kelch样蛋白31抗体
hz-8058R KLHL32 Kelch样蛋白32抗体
hz-8059R TMhz2L/KIAA1199 跨膜蛋白2样蛋白抗体
hz-8060R SAMHD1/HDDC1/MOP5 单核细胞蛋白5抗体
hz-0106M beta-Amyloid(1-40) β淀粉样肽(1-40)抗体
hz-8061R HDDC3 四磷酸鸟苷水解酶抗体
hz-8062R PLEKHM1 石骨症相关蛋白PLEKHM1抗体
hz-8063R PLEKHM2/SKIP 血小板白细胞C激酶底物同源结构域M2抗体
hz-8064R PLEKHM3 血小板白细胞C激酶底物同源结构域M3抗体
hz-8065R PID1 磷酸相互作用结构域蛋白1抗体
hz-0877R beta-Amyloid 1-40(CT) β淀粉样肽1-40(C端)抗体
hz-8066R SRRM1 丝氨酸/精氨酸相关核基质蛋白1抗体
hz-8067R SRRM2 丝氨酸/精氨酸相关核基质蛋白2抗体
hz-8068R SRRM3 丝氨酸/精氨酸相关核基质蛋白3抗体
hz-0877M beta-Amyloid 1-40(CT) β淀粉样肽 1-40(C端)抗体
hz-8069R SRRM4 丝氨酸/精氨酸相关核基质蛋白4抗体
hz-8070R ADCK4 ADCK4蛋白抗体
hz-8071R ADCK3/CABC1 伴侣蛋白bc1同源复合体抗体
hz-8072R AGFG1 艾滋病病毒复制结合蛋白抗体
hz-8073R AGFG2 HIV-1病毒复制结合蛋白2抗体
hz-8074R ANKRD1/CARP 心肌锚蛋白重复结构域1抗体
hz-8075R ARRDC1 抑制蛋白结构域蛋白1抗体
hz-8076R ARRDC2 抑制蛋白结构域蛋白2抗体
hz-8077R ARRDC3 抑制蛋白结构域蛋白3抗体
hz-8078R ARRDC4 抑制蛋白结构域蛋白4抗体
hz-8079R CCDC134 卷曲螺旋结构域蛋白134抗体
hz-8080R CCDC58 卷曲螺旋结构域蛋白58抗体
hz-0107R β-Amyloid(1-42) β淀粉样肽(1-42)抗体
hz-8081R CCDC94 卷曲螺旋结构域蛋白94抗体
hz-8082R CCDC135 卷曲螺旋结构域蛋白135抗体
hz-8083R CCDC124 卷曲螺旋结构域蛋白124抗体
hz-8084R CCDC112/MBC1 膀胱癌突变蛋白1抗体
hz-8085R CCDC82 卷曲螺旋结构域蛋白82抗体
hz-8086R CCDC68/se57-1 卷曲螺旋结构域蛋白68抗体(皮肤T淋巴细胞淋巴瘤相关抗原)
hz-8087R CCDC83 卷曲螺旋结构域蛋白83抗体
hz-8088R CCDC120 卷曲螺旋结构域蛋白120抗体