产品详情
英文名称 Thrombomodulin
中文名称 凝血调节蛋白/血栓调节素抗体
别 名 Thrombomodulin; CD 141; CD141; CD141 antigen; Fetomodulin; THBD; THRM; TM; AHUS 6; AHUS6; BDCA 3; BDCA3; THPH12; TRBM_HUMAN.
凝血调节蛋白/血栓调节素抗体
说 明 书 0.1ml 0.2ml
研究领域 心血管 转运蛋白 糖蛋白 内皮细胞
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse, Rat, Dog, Cow,
产品应用 WB=1:100-500 ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 Flow-Cyt=1:100-500 ICC=1:100-500 IF=1:100-500 (石蜡切片需做抗原修复)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 58/63kDa
性 状 Lyophilized or Liquid
浓 度 1mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from human CD141 N-terminus
亚 型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
凝血调节蛋白/血栓调节素抗体 产品介绍 background:
Thrombomodulin, TM is cell surface glycoprotein; plays an important role in the protein C anticoagulant pathway. It located in a vein, artery and capillary endothelial cells on the surface of plasma membrane protein. It is generally believed: TM vascular endothelial injury is an important parameter is the thrombin receptor, known in a variety of normal human tissues, can also be expressed in many tumors, TM may be similar to the E-cadherin,and is a lectin Like activity of a new class of members of the cell adhesion molecules.
CD141/Thrombomodulin is an exclusively endothelial cell surface glycoprotein that forms a 1:1 complex with thrombin. Binding of thrombin to this high-affinity receptor alters its specificity toward several substrates. The complex activates protein C approximately 1000 times faster than thrombin alone. Activated protein C degrades clotting factors V and VIII; thus, thrombomodulin converts thrombin into a physiologic anticoagulant. Thrombomodulin is also found in the circulatory and urinary systems, the physiologic significance of this is obscure.
Function:
Thrombomodulin is a specific endothelial cell receptor that forms a 1:1 stoichiometric complex with thrombin. This complex is responsible for the conversion of protein C to the activated protein C (protein Ca). Once evolved, protein Ca scissions the activated cofactors of the coagulation mechanism, factor Va and factor VIIIa, and thereby reduces the amount of thrombin generated.
Subcellular Location:
Membrane; Single-pass type I membrane protein.
Tissue Specificity:
Endothelial cells are unique in synthesizing thrombomodulin.
Post-translational modifications:
N-glycosylated.
The iron and 2-oxoglutarate dependent 3-hydroxylation of aspartate and asparagine is (R) stereospecific within EGF domains.
DISEASE:
Defects in THBD are the cause of thrombophilia due to thrombomodulin defect (THPH12) [MIM:614486]. A hemostatic disorder characterized by a tendency to thrombosis.
Defects in THBD are a cause of susceptibility to hemolytic uremic syndrome atypical type 6 (AHUS6) [MIM:612926]. An atypical form of hemolytic uremic syndrome. It is a complex genetic disease characterized by microangiopathic hemolytic anemia, thrombocytopenia, renal failure and absence of episodes of enterocolitis and diarrhea. In contrast to typical hemolytic uremic syndrome, atypical forms have a poorer prognosis, with higher death rates and frequent progression to end-stage renal disease. Note=Susceptibility to the development of atypical hemolytic uremic syndrome can be conferred by mutations in various components of or regulatory factors in the complement cascade system. Other genes may play a role in modifying the phenotype.
Similarity:
Contains 1 C-type lectin domain.
Contains 6 EGF-like domains.
Gene ID:
7056
Database links:
Entrez Gene: 7056 Human
Entrez Gene: 83580 Rat
Omim: 188040 Human
SwissProt: P07204 Human
Unigene: 2030 Human
Unigene: 88295 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
凝血调节蛋白/血栓调节素抗体
hz-4290R CDC37 Hsp90辅助伴侣分子CDC37抗体
hz-1208R ADAMTS1 整合素样金属蛋白酶与凝血酶1型抗体
hz-4191R ADAMTS4 整合素样金属蛋白酶与凝血酶4型抗体
hz-4192R SLC25A20 线粒体二羧酸载体蛋白20抗体
hz-4180R P2Y2 嘌呤ATP受体抗体
hz-4273R PIH1D1/NOP17 核仁同源蛋白17抗体
hz-4258R Vesicle docking protein p115 囊泡对接蛋白p115抗体
hz-0433R ADAMTS7 整合素样金属蛋白酶与凝血酶1型-7抗体
hz-4500R BRLF1 EBV立即早期基因BRLF1抗体
hz-4501R Cancer/testis antigen 1B/1A 肿瘤/睾丸抗原1B/1A
hz-0733R ADAMTS7(NT) 整合素样金属蛋白酶与凝血酶1型-7抗体 (N端抗体)
hz-4503R CTAG1B/Cancer/testis antigen 1 肿瘤/睾丸抗原1B
hz-5859R ADAMTS8 整合素样金属蛋白酶与凝血酶8型抗体
hz-4507R PRRSV M protein 猪蓝耳病病毒M蛋白抗体
hz-4516R CPN10 叶绿体伴侣蛋白抗体(苹果)
hz-4524R FMDV Polyprotein (3D polymerase) 口蹄疫病毒
hz-4532R Clenbuterol Hydrochloride(Spiropent) 盐酸克仑特罗/瘦肉精抗体
hz-4541R Chloramphenicol 氯霉素抗体
hz-2167R ADAR1 (N-terminus) 双链RNA腺苷酸脱氨基酶抗体(N端)
hz-4542R BRLF1 立即早期癌基因BRLF1抗体(鼻咽癌基因)
hz-2168R ADAR1 (C-terminus) 双链RNA腺苷酸脱氨基酶抗体(C端)
hzm-4545M Ractopamine /PAYLEAN (1B12) 小鼠抗莱克多巴胺单克隆抗体
hz-4549R Cellulase 纤维素酶
hz-4550R Pectinesterase 果胶酶抗体
hz-4556R DLK1/Delta/DLL1 (C-terminus) 穿膜蛋白DLK1抗体(C端)
hz-4559R ADD1/alpha Adducin 内收蛋白a1抗体
hz-4560R Gibberellins 牛磺酸/β-氨基乙磺酸抗体
hz-4567R EGF 表皮生长因子抗体
hz-4568M EGF 小鼠抗表皮生长因子抗体
hz-4568R EGF 抗表皮生长因子抗体
hz-4587R IL-6 白介素6抗体
hz-4588R IGF I 胰岛素样生长因子1抗体
hz-4590R PPAR Gamma 过氧化酶活化增生受体γ抗体
hz-4210R C9orf156 9号染色体开放阅读框156抗体
hz-4592R P14ARF/CDKN2A 抑癌基因p16抗体
hz-4593R MMP9 基质金属蛋白酶9抗体
hz-4600R TIMP-1(CT) 金属蛋白酶组织抑制因子-1抗体(C端)
hz-1114R Adducin protein 内收蛋白抗体
hz-4601R phospho-c-Jun(Thr91+Thr93) 磷酸化原癌基因c-Jun抗体