产品详情
英文名称 TBX2
中文名称 新型抑癌基因抗体
别 名 T-bet; Tbx21; T-box2; T-box Protein 2; T-box transcription factor TBX2; T-box protein 2; FLJ10169; HGNC: 11597; T box 2; T box transcription factor TBX2; TBX2; TBX2_HUMAN.
新型抑癌基因抗体
说 明 书 0.1ml 0.2ml
研究领域 肿瘤 细胞生物 信号转导 细胞凋亡
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse, Rat,
产品应用 WB=1:100-500 ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 74kDa
细胞定位 细胞核
性 状 Lyophilized or Liquid
浓 度 1mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from human TBX2
亚 型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
新型抑癌基因抗体产品介绍 background:
This gene is a member of a phylogenetically conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. This gene product is the human homolog of mouse Tbx2, and shares strong sequence similarity with Drosophila omb protein. Expression studies indicate that this gene may have a potential role in tumorigenesis as an immortalizing agent. Transcript heterogeneity due to alternative polyadenylation has been noted for this gene.
Function:
Involved in the transcriptional regulation of genes required for mesoderm differentiation. Probably plays a role in limb pattern formation. Acts as a negative regulator of PML function in cellular senescence.
Subunit:
Interacts with PML (isoform-PML-2, isoform PML-3 and isoform PML-4).
Subcellular Location:
Nucleus.
Tissue Specificity:
Expressed primarily in adult in kidney, lung, and placenta. Weak expression in heart and ovary.
Similarity:
Contains 1 T-box DNA-binding domain.
Gene ID:
30009
Database links:
Entrez Gene: 30009 Human
Entrez Gene: 57765 Mouse
Entrez Gene: 303496 Rat
Omim: 604895 Human
SwissProt: Q9UL17 Human
SwissProt: Q9JKD8 Mouse
Unigene: 272409 Human
Unigene: 94519 Mouse
Unigene: 144930 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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