产品详情
英文名称 SCIN
中文名称 肌切蛋白抗体
别 名 Adseverin; KIAA1905; ADSV_HUMAN; Scinderin.
肌切蛋白抗体
说 明 书 0.2ml
研究领域 细胞生物 信号转导 细胞骨架
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse, Rat, Dog, Cow, Horse, Sheep,
产品应用 WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 (石蜡切片需做抗原修复)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 80kDa
细胞定位 细胞浆
性 状 Lyophilized or Liquid
浓 度 1mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from human SCIN
亚 型 IgG
纯化方法 affinity purified by Protein A
储 存 液 Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
肌切蛋白抗体 产品介绍 background:
SCIN (Scinderin) is a Ca(2+) dependent actin filament severing protein that is presumed to have a regulatory function in exocytosis by affecting the organization of the microfilament network underneath the plasma membrane. In vitro SCIN also has barbed end capping and nucleating activities in the presence of Ca(2+).
Function:
Ca(2+)-dependent actin filament-severing protein that is presumed to have a regulatory function in exocytosis by affecting the organization of the microfilament network underneath the plasma membrane. In vitro, also has barbed end capping and nucleating activities in the presence of Ca(2+). Regulates chondrocyte proliferation and differentiation. MAP kinases p38 and ERK1/2 mediate the adseverin-induced accelerated differentiation of non-hypertrophic chondrocytes (By similarity).
Subcellular Location:
Cytoplasmic, cytoskeleton.
Similarity:
Belongs to the villin/gelsolin family.
Contains 6 gelsolin-like repeats.
Gene ID:
85477
Database links:
Entrez Gene: 85477 Human
Omim: 613416 Human
SwissProt: Q9Y6U3 Human
SwissProt: D4A2G2 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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