产品详情
英文名称 SCNM1
中文名称 钠离子通道调节蛋白1抗体
别 名 SCNM 1; Sodium channel modifier 1.
钠离子通道调节蛋白1抗体
说 明 书 0.2ml
研究领域 细胞生物 免疫学 锌指蛋白 表观遗传学
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse, Rat,
产品应用 WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 (石蜡切片需做抗原修复)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 26kDa
细胞定位 细胞核
性 状 Lyophilized or Liquid
浓 度 1mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from human SCNM1
亚 型 IgG
纯化方法 affinity purified by Protein A
储 存 液 Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
钠离子通道调节蛋白1抗体产品介绍 background:
Zinc-finger proteins contain DNA-binding domains and have a wide variety of functions, most of which encompass some form of transcriptional activation or repression. SCNM1 (sodium channel modifier 1) is a 230 amino acid protein that contains one matrin-type zinc finger. Localized to the nucleus, SCNM1 is thought to function as an RNA splicing factor that may modify the expression of sodium channel-related proteins. SCNM1 exists as two alternatively spliced isoforms that are encoded by a gene which maps to chromosome 1. Chromosome 1 is the largest human chromosome, spanning about 260 million base pairs and making up 8% of the human genome. Several disorders, including Stickler syndrome, Parkinsons Disease, Gaucher disease, malignant melanoma and Usher syndrome, are caused by defects in genes that localize to chromosome 1
Function:
SCNM1 (Sodium channel modifier 1) contains a matrin-type zinc finger. It is thought to function as an RNA splicing factor. It is a disease modifier gene, that modifies phenotypic expression of SCN8A mutations in mice and is required for efficient in vivo splicing of a mutant splice donor site in the sodium channel SCN8A.
Subcellular Location:
Nuclear
Database links:
Entrez Gene: 79005 Human
Omim: 608095 Human
SwissProt: Q9BWG6 Human
Unigene: 732060 Human
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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