产品详情
英文名称 SNX5
中文名称 分选连接蛋白5抗体
别 名 0910001N05Rik; 1810032P22Rik; AU019504; D2Ertd52e; FLJ10931; OTTHUMP00000030340; OTTHUMP00000062927; OTTMUSP00000003367; OTTMUSP00000003368; RP11-504H3.2; RP23-35E16.2; snoRNA MBI-43; SNX 5; SNX5; SNX5_HUMAN; Sorting nexin 5; Sorting nexin-5.
分选连接蛋白5抗体
说 明 书 0.1ml 0.2ml
研究领域 细胞生物 信号转导 生长因子和激素 转录调节因子 激酶和磷酸酶
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit, Sheep,
产品应用 WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 (石蜡切片需做抗原修复)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 47
on line abortion pill click where to buy abortion pill
kDa
细胞定位 细胞浆 细胞膜
性 状 Lyophilized or Liquid
浓 度 1mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from Human SNX5 (2-75aa)
亚 型 IgG
纯化方法 affinity purified by Protein A
储 存 液 Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
分选连接蛋白5抗体产品介绍 background:
Sorting nexin 1 (SNX1) is a member of a large family of hydrophilic proteins that interact with a variety of receptor types and are involved in intracellular trafficking (1). SNX1 and the related splice variant, SNX1A, bind the epidermal growth factor (EGF) receptor, facilitate its transport to lysosome, and thereby contribute to the degradation of the receptor (2,3). SNX2 and SNX4 share a high degree of amino acid similarity with SNX1, as they all contain a characteristic phox homology (PX) domain (4). These proteins are all partially associated with cellular membranes, and they, likewise, associate with EGF, PDGF and insulin receptor tyrosine kinases (2). These nexins are widely expressed and yet have various tissue distribution patterns. Additionally, the sorting nexins can associate with each other and with a variety of other cellular proteins, suggesting that they exist as part of multisubunit complexes (1,5). The related protein, SNX3, comprises a distinct subgroup of nexins that share less sequence similarity outside of the PX domain and have dramatically different binding affinities for the tyrosine kinase receptors (2,6).
Function:
May be involved in several stages of intracellular trafficking. Plays a role in macropinocytosis. Plays a role in the internalization of EGFR after EGF stimulation.
on line abortion pill abortion pill where to buy abortion pill
Subunit:
Interacts with SNX1; this promotes location at the endosome membrane.
Subcellular Location:
Early endosome membrane; Peripheral membrane protein; Cytoplasmic side. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm. Cell projection, phagocytic cup. Cell projection, ruffle. Note=Recruited to the plasma membrane after EGF stimulation, which leads to increased levels of phosphatidylinositol 3,4-bisphosphate (PdtIns(3,4)P2). Detected on macropinosomes. Targeted to membrane ruffles in response to EGFR stimulation.
Post-translational modifications:
on line abortion pill click where to buy abortion pill
Similarity:
Belongs to the sorting nexin family.
Contains 1 BAR domain.
Contains 1 PX (phox homology) domain.
Database links:
UniProtKB/Swiss-Prot: Q9Y5X3.1
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
分选连接蛋白5抗体
hz-9699R C20orf196 20号染色体开放阅读框196抗体
hz-0167R APOE/Apo E2 载脂蛋白E抗体
hz-9700R C20orf43 20号染色体开放阅读框43抗体
hz-9701R GPCR GPR97 G蛋白偶联受体97抗体
hz-9702R HECA HECA蛋白抗体
hz-5039R APOE3 载脂蛋白E3抗体
hz-9703R Hornerin/S100A18 角化蛋白S100A16抗体
hz-9704R IFI35 干扰素诱导35蛋白抗体
hz-5038R APOE4/Apolipoprotein E4 载脂蛋白E4抗体
hz-9705R ITM2A 完整膜蛋白E25A抗体
hz-1354R APOJ/Clusterin 载脂蛋白J抗体
hz-9706R JWA JWA蛋白抗体
hz-9707R Kazrin Kazrin蛋白抗体
hz-9708R LCE1A 晚期包膜蛋白1抗体
hz-9709R LCE2B 晚期包膜蛋白2B抗体
hz-9710R NOL1 增殖相关核仁抗原抗体
hz-9711R LIPK 脂肪酶家庭成员K抗体
hz-9712R NHEDC2 线粒体钠/氢交换蛋白质2抗体
hz-9713R NOC3L/FAD24 脂肪细胞分化因子24
hz-9715R Sox9a 转录因子sox9a抗体
hz-9716R KBP KBP蛋白抗体
hz-9717R Nidogen 2 巢蛋白NID2抗体
hz-9718R Nanos3 骨巢蛋白抗体
hz-9719R PDE4A8 磷酸二酯酶4A8抗体
hz-9720R C10orf27/SPATIAL 第10号染色体开放阅读框27抗体
hz-9721R FEZ1 脑胚胎锌指样蛋白1抗体
hz-9723R FAM29A/HAUS6 FAM29蛋白抗体
hz-9724R E4F1 E4F转录因子1抗体
hz-9725R CHPT1 甘油二酯胆碱磷酸转移酶抗体
hz-9727R BIN2/BRAP1 乳腺癌相关蛋白1抗体
hz-9728R B4GALT7/GlcNAc beta 半乳糖转移酶7亚基β1,4抗体
hz-9729R FAM96B FAM96B蛋白抗体
hz-9730R FAM82B 微管相关蛋白FAM82B抗体
hz-9731R hzL3 微管相关蛋白样蛋白3抗体
hz-1489R Apollon/BIRC6 Apollon凋亡抑制蛋白抗体
hz-9732R ZWILCH 着丝粒ZWILCH蛋白抗体
hz-9733R UFD1L 泛素融合降解样蛋白1抗体
hz-9734R TSSK6/CT72 睾丸特异丝氨酸/苏氨酸激酶6抗体