产品详情
英文名称 SCP2
中文名称 固醇携带蛋白2抗体
别 名 DKFZp686C12188; DKFZp686D11188; NLTP; Nonspecific lipid transfer protein; NSL TP; OTTHUMP00000010488; Propanoyl CoA C acyltransferase; SCP 2; SCP chi; SCP X; SCP2; SCPchi; SCPX; Sterol carrier protein 2; Sterol carrier protein X; NLTP_HUMAN.
固醇携带蛋白2抗体
说 明 书 0.1ml 0.2ml
研究领域 心血管 细胞生物 免疫学 染色质和核信号 细胞周期蛋白 合成与降解 细胞分化 细胞骨架 线粒体
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse, Rat, Dog, Cow, Rabbit,
产品应用 WB=1:100-500 ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 (石蜡切片需做抗原修复)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 59kDa
细胞定位 细胞核 线粒体
性 状 Lyophilized or Liquid
浓 度 1mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from human SCP2
亚 型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
固醇携带蛋白2抗体产品介绍 background:
This gene encodes two proteins: sterol carrier protein X(SCPx) and sterol carrier protein 2 (SCP2), as a result of transcription initiation from 2 independently regulated promoters. The transcript initiated from the proximal promoter encodes the longer SCPx protein, and the transcript initiated from the distal promoter encodes the shorter SCP2 protein, with the 2 proteins sharing a common C-terminus. Evidence suggests that the SCPx protein is a peroxisome-associated thiolase that is involved in the oxidation of branched chain fatty acids, while the SCP2 protein is thought to be an intracellular lipid transfer protein. This gene is highly expressed in organs involved in lipid metabolism, and may play a role in Zellweger syndrome, in which cells are deficient in peroxisomes and have impaired bile acid synthesis. Alternative splicing of this gene produces multiple transcript variants, some encoding different isoforms. [provided by RefSeq, Aug 2010]
Function:
Mediates in vitro the transfer of all common phospholipids, cholesterol and gangliosides between membranes. May play a role in regulating steroidogenesis.
Subunit:
Interacts with PEX5.
Subcellular Location:
Cytoplasm. Mitochondrion. Note=Cytoplasmic in the liver and also associated with mitochondria especially in steroidogenic tissues.
Isoform SCPx: Peroxisome. Note=Interaction with PEX5 is essential for peroxisomal import.
Isoform SCP2: Mitochondrion (Probable).
Tissue Specificity:
Liver, fibroblasts, and placenta.
DISEASE:
Leukoencephalopathy, with dystonia and motor neuropathy (LDMN) [MIM:613724]: A syndrome characterized by leukoencephalopathy, dystonic head tremor, spasmodic torticollis and reduced tendon reflexes in lower extremities. Additional features include hyposmia, pathologic saccadic eye movements, a slight hypoacusis, accumulation of branched-chain pristanic acid in plasma, and the presence of abnormal bile alcohol glucuronides in urine. Note=The disease is caused by mutations affecting the gene represented in this entry.
Similarity:
In the N-terminal section; belongs to the thiolase family.
Contains 1 SCP2 domain.
Gene ID:
6342
Database links:
Entrez Gene: 6342 Human
Entrez Gene: 20280 Mouse
Entrez Gene: 25541 Rat
Omim: 184755 Human
SwissProt: P22307 Human
SwissProt: P32020 Mouse
SwissProt: P11915 Rat
Unigene: 476365 Human
Unigene: 379011 Mouse
Unigene: 31887 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
固醇携带蛋白2抗体
hz-5690R phospho-Rab24(Ser95) 磷酸化ras基因相关蛋白Rab24抗体
hz-5691R phospho-Rab24(Tyr17) 磷酸化ras基因相关蛋白Rab24抗体
hz-1221R Rad51 Rad51抗体
hz-1878R Rad52 Rad52抗体
hz-5684R phospho-RAD51(Tyr315) 磷酸化Rad51抗体
hz-2186R RAD51C 乳腺癌和卵巢癌易感基因RAD51C抗体
hz-3791R RAE1 mRNA结合蛋白抗体
hz-3808R Radixin 根蛋白抗体
hz-3559R Raptor mTOR相关调控蛋白抗体
hz-3381R Phospho-Raptor (Ser792) 磷酸化mTOR相关调控蛋白抗体
hz-1504R RAP1A 抗Rap1A抗体
hz-5106R ALDH1 乙醛脱氢酶1型抗体
hz-5110R ALDH2/ALDHI 乙醛脱氢酶2抗体
hz-3676R RALDH2 视黄醛脱氢酶2型抗体
hz-5709R ALDH1L1 乙醛脱氢酶1蛋白家族L1抗体
hz-1731R phospho-c-Raf(Ser338/Tyr340) 磷酸化原癌基因c-Raf抗体
hz-3372R phospho-c-Raf (Ser289) 磷酸化原癌基因c-Raf抗体
hz-3375R phospho-c-Raf(Ser259) 磷酸化原癌基因c-Raf抗体
hz-3376R phospho-c-Raf(Ser296) 磷酸化原癌基因c-Raf抗体
hz-3377R phospho-c-Raf(Ser338) 磷酸化原癌基因c-Raf抗体
hz-5645R phospho-c-Raf(Ser301) 磷酸化原癌基因c-Raf抗体
hz-5646R phospho-c-Raf(Ser462) 磷酸化原癌基因c-Raf抗体
hz-5647R phospho-c-Raf(Ser494) 磷酸化原癌基因c-Raf抗体
hz-5648R phospho-c-Raf(Ser43) 磷酸化原癌基因c-Raf抗体
hz-5649R phospho-c-Raf(Ser471) 磷酸化原癌基因c-Raf抗体
hz-5650R phospho-c-Raf(Tyr341) 磷酸化原癌基因c-Raf抗体
hz-5651R phospho-c-Raf(Thr269) 磷酸化原癌基因c-Raf抗体
hz-3560R RASGRF1 Ras特异性鸟嘌呤核苷酸释放因子1
hz-3382R Phospho-RasGRF1(Ser916) 磷酸化Ras特异性鸟嘌呤核苷酸释放因子1
hz-5652R phospho-c-Raf(Ser339) 磷酸化原癌基因c-Raf抗体
hz-5683R Phospho-RASGRF1(Ser929) 磷酸化Ras特异性鸟嘌呤核苷酸释放因子1
hz-0251R RAR α 维甲酸受体-α 抗体
hz-0516R RAR Beta 维甲酸受体β抗体
hz-6218R RAR gamma/Retinoic Acid Receptor gamma 维甲酸受体γ抗体
hz-1234R RASSF1A Ras相关区域家族1A抗体
hz-5706R RASSF4 Ras相关区域家族蛋白4抗体
hz-2939R RASSF2 Ras相关结构域蛋白质2抗体
hz-6089R RASSF8 RAS家族关联结构域蛋白8抗体
hz-1515R Pan-ras Pan ras抗体
hz-3545R RCC1 染色体浓缩调控蛋白1抗体
hz-3360R Phospho-RCC1 (Ser11) 磷酸化染色体浓缩调控蛋白1抗体
hz-3558R phospho-Rb(Ser249) 视网膜母细胞瘤相关蛋白1抗体
hz-3378R Phospho-Rb (Ser608) 磷酸化视网膜母细胞瘤相关蛋白1抗体
hz-3380R Phospho-Rb (Ser807/Ser811) 磷酸化视网膜母细胞瘤相关蛋白1抗体