产品详情
英文名称 SPA-1
中文名称 信号感应增殖相关蛋白1抗体
别 名 GTPase activating protein Spa 1; GTPase-activating protein Spa-1; MGC102688; MGC17037; p130 SPA-1; p130 SPA1; Signal induced proliferation associated 1; Signal induced proliferation associated gene 1; Signal induced proliferation associated protein 1; signal-induced proliferation-associated gene 1; Signal-induced proliferation-associated protein 1; SIPA 1; Sipa-1; Sipa1; SIPA1_HUMAN; Spa1.
信号感应增殖相关蛋白1抗体
说 明 书 0.1ml 0.2ml
研究领域 肿瘤 细胞生物 染色质和核信号 信号转导 干细胞 细胞凋亡 细胞周期蛋白 细胞表面分子 表观遗传学 G蛋白信号
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse, Rat, Dog, Pig, Cow, Horse,
产品应用 WB=1:100-500 ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 (石蜡切片需做抗原修复)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 112kDa
细胞定位 细胞核 细胞浆 细胞膜
性 状 Lyophilized or Liquid
浓 度 1mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from human SPA-1
亚 型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
信号感应增殖相关蛋白1抗体产品介绍 background:
The product of this gene is a mitogen induced GTPase activating protein (GAP). It exhibits a specific GAP activity for Ras-related regulatory proteins Rap1 and Rap2, but not for Ran or other small GTPases. This protein may also hamper mitogen-induced cell cycle progression when abnormally or prematurely expressed. It is localized to the perinuclear region. Two alternatively spliced variants encoding the same isoform have been characterized to date.
Function:
GTPase activator for the nuclear Ras-related regulatory proteins Rap1 and Rap2 in vitro, converting it to the putatively inactive GDP-bound state.
Subcellular Location:
Nucleus. Cytoplasm, perinuclear region. Endomembrane system; Peripheral membrane protein. Note=Mostly localized in the perinuclear membraneous region.
Tissue Specificity:
Expressed in fetal as well as in adult tissues. Expressed abundantly in the lymphoid tissues such as thymus, spleen and peripheral blood lymphocytes and also shows a significant expression in the spinal cord.
Similarity:
Contains 1 PDZ (DHR) domain.
Contains 1 Rap-GAP domain.
Gene ID:
6494
Database links:
Entrez Gene: 6494 Human
Entrez Gene: 20469 Mouse
Omim: 602180 Human
SwissProt: Q96FS4 Human
SwissProt: P46062 Mouse
Unigene: 530477 Human
Unigene: 3072 Mouse
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
信号感应增殖相关蛋白1抗体
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