产品详情
英文名称 Runx3
中文名称 Runx3抗体
别 名 RUNX 3; RUNX-3; Runt-related transcription factor 3; Core-binding factor, alpha 3 subunit; CBF-alpha 3; Acute myeloid leukemia 2 protein; OncogeneAML-2; Polyomavirus enhancer-binding protein 2 alpha C subunit; PEBP2-alpha C; PEA2-alpha C; SL3-3 enhancer factor 1 alpha C subunit; SL3/AKV core-binding factor alpha C subunit; Core-binding factor, alpha 3 subunit; CBF-alpha 3; Acute myeloid leukemia 2 protein; Oncogene AML-2; Polyomavirus enhancer-binding protein 2 alpha C subunit; PEBP2-alpha C; PEA2-alpha C; SL3-3 enhancer factor 1 alpha C subunit; SL3/AKV core-binding factor alpha C subunit.
Runx3抗体
说 明 书 0.1ml 0.2ml
研究领域 肿瘤 细胞生物 转运蛋白 表观遗传学
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse, Rat, Chicken, Dog, Cow, Horse, Sheep,
产品应用 WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 (石蜡切片需做抗原修复)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 47kDa
细胞定位 细胞核 细胞浆
性 状 Lyophilized or Liquid
浓 度 1mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from human Runx3
亚 型 IgG
纯化方法 affinity purified by Protein A
储 存 液 Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Runx3抗体产品介绍 background:
RUNX3 binds to the core site of murine Leukemia virus, the core sequences in the enhancer of the polyomavirus, and also to the enhancers of the T-cell receptor genes. May be involved in the control of cellular proliferation and/or differentiation (By similarity). Heterodimer of an alpha and a beta subunit. The alpha subunit binds DNA as a monomer and through the Runt domain.DNA-binding is increased by heterodimerization. Interacts with TLE1 and SUV39H1, Subcellular location in Nucleus.
Function:
CBF binds to the core site, 5'-PYGPYGGT-3', of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, lck, IL-3 and GM-CSF promoters.
Subunit:
Heterodimer of an alpha and a beta subunit. The alpha subunit binds DNA as a monomer and through the Runt domain. DNA-binding is increased by heterodimerization. Interacts with TLE1 and SUV39H1. The tyrosine phosphorylated form (via runt domain) interacts with SRC (via protein kinase domain). Interacts with FYN and LCK.
Subcellular Location:
Nucleus. Cytoplasm. The tyrosine phosphorylated form localizes to the cytoplasm.
Post-translational modifications:
Phosphorylated on tyrosine residues by SRC. Phosphorylated by LCK and FYN.
Similarity:
Contains 1 Runt domain.
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
Runx3抗体
hz-4002P phospho-AMPK alpha 1(Thr172) peptaide 磷酸化腺苷单磷酸活化蛋白激酶α1抗原
hz-0049P Caspase-9 白介素1-β转化酶样凋亡蛋白酶6(抗原)
hz-0050P Caspase-9 白介素1-β转化酶样凋亡蛋白酶6(抗原)
hz-2105P AD7C-NTP/NTP/AF peptide 神经丝蛋白蛋白多肽抗原(人)
hz-0092P Caspase-10 半胱胺酸蛋白酶-10(抗原)
hz-0053P Caspase-13 半胱胺酸蛋白酶蛋白-13(抗原)
hz-0079P CD19(B-lymphocyte antigen CD19) CD19
hz-4532PB Clenbuterol Hydrochloride/BSA 盐酸克仑特罗偶联牛血清白蛋白BSA
hz-4532PK Clenbuterol Hydrochloride/KLH 盐酸克仑特罗偶联血蓝蛋白KLH
hz-4533PB Estradiol/BSA 雌二醇偶联牛血清白蛋白
hz-2167P DRADA/ADAR1(Double-stranded RNA-specific adenosine deaminase)N terminal 双链RNA腺苷酸脱氨基酶抗原(N端)
hz-2168P DRADA/ADAR1(Double-stranded RNA-specific adenosine deaminase) 双链RNA腺苷酸脱氨基酶抗原
hz-4545PB Ractopamine/BSA 莱克多巴胺与牛血清白蛋白偶联物
hz-4545PK Ractopamine/KLH 莱克多巴胺与血蓝蛋白偶联物
hz-4593P MMP9 基质金属蛋白酶9
hz-4609P CD105/Endoglin CD105蛋白
hz-4622P Mycobacterium bovis 牛结核杆菌菌体蛋白
hz-4687P AMH/MIS Muellerian抑制因子抗原
hz-2231P AEG-1 peptide AEG-1抗原
hz-0195P CD31 (PECAM-1) 血小板内皮细胞黏附分子-1(抗原)
hz-1164P ADFP/ADRP/adipophilin 脂肪组织分化相关蛋白抗原
hz-0298P Immunoglobuin binding protein-1(CD79A)IGBP-1 免疫球蛋白结合蛋白-1
hz-4770P CD133 造血干细胞抗原CD133
hz-0209P CD133 造血干细胞抗原(多肽抗原)
hz-4813P H5N1-H5 禽流感H5亚型全病毒
hz-4814P Newcastle disease virus 鸡新城疫疫苗(鸡瘟4型混合病毒)
hz-4938P SDF-1/CXCL12 基质细胞衍生因子1
hz-4948P Bacillus anthraci 炭疽杆菌菌体蛋白
hz-3681P ADCY1 peptide 腺苷酸环化酶1多肽抗原
hz-0125P c-erbB-2蛋白 c-erbB-2蛋白(抗原)
hz-0042P ChAT(Choline Acetyltransferase) 胆碱乙酰转移酶(抗原)
hz-5109P HCLS1 造血干细胞特异性蛋白
hz-0236P ChRM2 (Muscarinic Acetylcholine receptor M2) 毒蕈碱型乙酰胆碱受体(抗原)
hz-0274P C-Peptide( C-PEP ) C-肽(C肽)
hz-0062P CR (Calretinin) 钙结合蛋白(抗原)
hz-0155P CRP (C-reactive protin) C-反应蛋白(抗原)
hz-1225P ADORA3/A3AR(adenosine receptor A3) 腺苷受体A3抗原