英文名称    RAB3GAP2    

中文名称    RAB3-GTP酶激活蛋白催化亚单位2抗体    

别    名    DKFZp434D245; FLJ14579; KIAA0839; p150; Rab3 GAP p150; Rab3 GAP regulatory subunit; Rab3 GAP150; Rab3 GTPase activating protein 150 kDa subunit; Rab3 GTPase activating protein non catalytic subunit; RAB3 GTPase activating protein subunit 2 (non catalytic); RAB3 GTPase activating protein subunit 2; RAB3GAP150; RGAP iso; RP11 568G11.1; RBGPR_HUMAN.    

RAB3-GTP酶激活蛋白催化亚单位2抗体      

说 明 书    0.2ml      

研究领域    细胞生物  发育生物学  神经生物学  信号转导  G蛋白信号      

抗体来源    Rabbit    

克隆类型    Polyclonal    

交叉反应    Human, Mouse, Rat, Dog, Cow, Horse, Rabbit, Sheep,     

产品应用    WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.    

分 子 量    156kDa    

细胞定位    细胞浆     

性    状    Lyophilized or Liquid    

浓    度    1mg/1ml    

免 疫 原    KLH conjugated synthetic peptide derived from human RAB3GAP2    

亚    型    IgG    

纯化方法    affinity purified by Protein A    

储 存 液    Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4    

保存条件    Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.    

RAB3-GTP酶激活蛋白催化亚单位2抗体产品介绍    background:
ab 3 GAP p150 is a ubiquitously expressed protein that contains 1,393 amino acids and belongs to the Rab3-GAP regulatory subunit family. Defects in Rab 3 GAP p150 are the cause of Martsolf and Warburg Micro syndrome. Both syndromes are characterized by congenital cataracts, microphthalmia, postnatal microcephaly and developmental delay, and are inherited in an autosomal recessive manner. The Rab3 GTPase-activating complex is a heterodimer composed of RAB3GAP and Rab 3 GAP p150 that interacts with DMXL2. Existing as two alternatively spliced isoforms, the Rab 3 GAP p150 gene is conserved in chimpanzee, dog, cow, rat, chicken, zebrafish, fruit fly, mosquito, A.thaliana and rice. The Rab 3 GAP p150 gene contains 36 exons and maps to human chromosome 1q41.

Function:
RAB3GAP2 is a regulatory subunit of a GTPase activating protein that has specificity for Rab3 subfamily (RAB3A, RAB3B, RAB3C and RAB3D). Rab3 proteins are involved in regulated exocytosis of neurotransmitters and hormones. Rab3 GTPase-activating complex specifically converts active Rab3-GTP to the inactive form Rab3-GDP. It is required for normal eye and brain development and may participate in neurodevelopmental processes such as proliferation, migration and differentiation before synapse formation, and non-synaptic vesicular release of neurotransmitters.

Subunit:
The Rab3 GTPase-activating complex is a heterodimer composed of RAB3GAP and RAB3-GAP150. The Rab3 GTPase-activating complex interacts with DMXL2

Subcellular Location:
Cytoplasm. Note=In neurons, it is enriched in the synaptic soluble fraction.

Tissue Specificity:
Ubiquitous.

DISEASE:
efects in RAB3GAP2 are the cause of Martsolf syndrome (MARTS) [MIM:212720]. Martsolf syndrome is characterized by congenital cataracts, mental retardation, and hypogonadism. Inheritance is autosomal recessive. 
Defects in RAB3GAP2 are the cause of Warburg micro syndrome type 2 (WARBM2) [MIM:614225]. WARBM2 is a rare syndrome characterized by microcephaly, microphthalmia, microcornia, congenital cataracts, optic atrophy, cortical dysplasia, in particular corpus callosum hypoplasia, severe mental retardation, spastic diplegia, and hypogonadism. 

Similarity:
Belongs to the Rab3-GAP regulatory subunit family.

Gene ID:
25782

Database links:

Entrez Gene: 25782 Human

Entrez Gene: 98732 Mouse

Entrez Gene: 289350 Rat

Omim: 609275 Human

SwissProt: Q9H2M9 Human

SwissProt: Q8BMG7 Mouse

SwissProt: Q5U1Z0 Rat

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.    

RAB3-GTP酶激活蛋白催化亚单位2抗体

hz-0635P SSA/RO (ribonucleoprotein complex,RNP)  核糖核蛋白抗原RO/SSA(抗原)

hz-0276P SSB/La  干燥症SSB/La蛋白

hz-0718P Smad2(Mothers against decapentaplegic homolog 2)  Smad 2(抗原)

hz-0717P SPAG5/map126   精子相关抗原5(多肽抗原)

hz-0770P SP-A (pulmonary surfactant-associated glycoprotein A)  肺表面活性蛋白A(抗原)

hz-0679P SYVN1(synovial apoptosis inhibitor 1)  滑膜细胞凋亡抑制物1（抗体）

hz-0685P SYK (Spleen tyrosine kinase)  非受体型酪氨酸激酶(抗原)

hz-0419P Tau protein  微管相关蛋白（抗原）

hz-0778P Thy-1/CD90  CD90(抗原)

hz-0632P Thioster-containing protein 1  硫酯包含蛋白-1(抗原)

hz-0640P TIGAR humen (TP53- induced glycolysis and apoptosis-regulator )  P53诱导糖酵解和凋亡调节因子蛋白（抗原）

hz-0418P TIMP-4(Tissue Inhibitor of Metalloproteinase-4)  金属蛋白酶组织抑制因子-4(抗原)

hz-0447P TPO(Thyroid Peroxidase)  甲状腺过氧化物酶(抗原)

hz-0460P TSHR (Thyroid stimulating hormone receptor)  促甲状腺素受体（抗原）

hz-0449P TSLP(Thymic stromal lymphopoietin isoform 1)  淋巴细胞生成素-1（抗原）

hz-0446P TTF-2(thyroid transcription factor 2;forkhead box E1)  甲状腺转录因子-2(抗原)

hz-0819P Tyrosinase  酪氨酸酶(多肽抗原)

hz-0603P OAT4L又称URAT1 (Urate Transporter 1)  尿酸盐重吸收转运子1 (抗原)

hz-0853P VAP1(vascular adhesion protein 1)  血管粘附蛋白1（多肽抗原）

hz-0756P Vimentin  波形蛋白（抗原）

hz-0479P VSIG4 (V-set and immunoglobulin domain-containing protein 4)  VSIG4 T淋巴细胞负调节蛋白之一（抗原）

hz-0429P WNK4(Ser/Thr-protein kinase WNK4; protein kinase with no lysine 4; protein kinase, lysine –dficient 4)  一种新的丝氨酸/苏氨酸激酶家族成员的基因WNK4（多肽抗原）

hz-0628P ZNF300 (zinc finger protein ZNF300)- middle  锌指蛋白300(抗原)

hz-0625P ZNF268 (zinc finger protein ZNF268)- N-terminal (1a)  锌指脂蛋白-1a(抗原)

hz-0626P ZNF268 (zinc finger protein ZNF268)- middle (1b)  锌指脂蛋白-1b(抗原）

hz-0627P ZNF268 (zinc finger protein ZNF268)- middle (1c)  人锌指脂蛋白-1c(抗原)

hz-0480P IFN- Gamma(Interferon Gamma)Ag-mouse、rat  干扰素-γ多肽抗原（大、小鼠）

hz-0481P IFN- Gamma(Interferon Gamma)Human  干扰素-γ多肽抗原（人）

hz-0784P IFN- Beta (Interferon Beta)Anti-mouse,rat  干扰素-β抗原

hz-0787P IFN- Beta (Interferon Beta) human  干扰素-β抗原

hz-0669P PSCA  前列腺干细胞抗原

hz-1930P ADH/AVP peptide  抗利尿激素/血管升压素抗原（和肽素）

hz-4507P PRRSV M protein  猪蓝耳病病毒M蛋白

hz-4814P-HRP Newcastle disease virus/HRP  鸡新城疫疫苗（鸡瘟4型混合病毒）偶联辣根过氧化物酶

hz-0645P sIgA  大鼠分泌型IgA(抗原)

hz-0904PK Melamine/KLH  三聚氰胺与血蓝蛋白偶联物

hz-0904PB Melamine/BSA  三聚氰胺与牛血清白蛋白偶联物