产品详情
磷酸化热休克蛋白β5/αb晶体蛋白质/α-晶体蛋白b链抗体Quantity size:
0.1ml
Concentration:
1mg/ml Buffer = 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Background:
Crystallins are separated into two classes: taxon-specific, or enzyme, and ubiquitous. The latter class constitutes the major proteins of vertebrate eye lens and maintains the transparency and refractive index of the lens. Since lens central fiber cells lose their nuclei during development, these crystallins are made and then retained throughout life, making them extremely stable proteins. Mammalian lens crystallins are divided into alpha, beta, and gamma families; beta and gamma crystallins are also considered as a superfamily. Alpha and beta families are further divided into acidic and basic groups.磷酸化热休克蛋白β5/αb晶体蛋白质/α-晶体蛋白b链抗体 Seven protein regions exist in crystallins: four homologous motifs, a connecting peptide, and N- and C-terminal extensions. Alpha crystallins are composed of two gene products: alpha-A and alpha-B, for acidic and basic, respectively. Alpha crystallins can be induced by heat shock and are members of the small heat shock protein (sHSP also known as the HSP20) family. They act as molecular chaperones although they do not renature proteins and release them in the fashion of a true chaperone; instead they hold them in large soluble aggregates. Post-translational modifications decrease the ability to chaperone. These heterogeneous aggregates consist of 30-40 subunits; 磷酸化热休克蛋白β5/αb晶体蛋白质/α-晶体蛋白b链抗体the alpha-A and alpha-B subunits have a 3:1 ratio, respectively. Two additional functions of alpha crystallins are an autokinase activity and participation in the intracellular architecture. Alpha-A and alpha-B gene products are differentially expressed; alpha-A is preferentially restricted to the lens and alpha-B is expressed widely in many tissues and organs. Elevated expression of alpha-B crystallin occurs in many neurological diseases; a missense mutation cosegregated in a family with a desmin-related myopathy. [provided by RefSeq, Jul 2008].
磷酸化热休克蛋白β5/αb晶体蛋白质/α-晶体蛋白b链抗体Also known as:
alpha B Crystallin (phospho S59); alpha B Crystallin (phospho Ser59); p-alpha B Crystallin (S59); p-alpha B Crystallin (Ser59); AACRYA; Alpha B crystallin; Alpha crystallin B chain; Alpha crystallin B chain; Alpha(B) crystallin; Alpha(B)-crystallin; Alpha-crystallin B chain; CRYA2; CRYAB; CRYAB_HUMAN; Crystallin alpha B; Crystallin alpha polypeptide 2; CTPP 2; CTPP2; Heat shock 20 kD like protein; Heat shock protein beta 5; Heat shock protein beta-5; HSPB5; NY REN 27 antigen; Renal carcinoma antigen NY REN 27; Renal carcinoma antigen NY-REN-27; Rosenthal fiber component.
Specificity:
●
Rabbit Polyclonal IgG, affinity purified by Protein A.
●
Reacts with: Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, Sheep, Guinea Pig, Hamster, .
●
Immunogen: KLH conjugated synthesised phosphopeptide derived from human alpha B Crystallin around the phosphorylation site of Ser59.
●
磷酸化热休克蛋白β5/αb晶体蛋白质/α-晶体蛋白b链抗体Predicted Molecular Weight: 20kDa.
Storage:
Shipped at 4℃, Store at -20℃ (Avoid repeated freeze/thaw cycles).
Application:
WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500
Not yet tested in other applications.
Optimal working dilutions must be determined by the end user.
kl549Ra01无翅型MMTV整合位点家族成员5A(WNT5A)多克隆抗体Polyclonal Antibody to Wingless Type MMTV Integration Site Family, Member 5A (WNT5A)
kl552Hu01无翅型MMTV整合位点家族成员11(WNT11)多克隆抗体Polyclonal Antibody to Wingless Type MMTV Integration Site Family, Member 11 (WNT11)
kl553Hu01无翅型MMTV整合位点家族成员10B(WNT10B)多克隆抗体Polyclonal Antibody to Wingless Type MMTV Integration Site Family, Member 10B (WNT10B)
kl574Hu01线粒体外膜转位酶70A(TOMM70A)多克隆抗体Polyclonal Antibody to Translocase Of Outer Mitochondrial Membrane 70A (TOMM70A)
kl643Hu01核糖体蛋白L23A(RPL23A)多克隆抗体Polyclonal Antibody to Ribosomal Protein L23A (RPL23A)
kl657Hu01瘤变抑制因子14(ST14)多克隆抗体Polyclonal Antibody to Suppression Of Tumorigenicity 14 (ST14)
kl710Hu01C-型凝集素域家族11成员A(CLEC11A)多克隆抗体Polyclonal Antibody to C-Type Lectin Domain Family 11, Member A (CLEC11A)
kl745Hu01G蛋白偶联受体家族C5组成员A(GPRC5A)多克隆抗体Polyclonal Antibody to G Protein Coupled Receptor, Family C, Group 5, Member A (GPRC5A)
kl750Hu01RAD51同源物(RAD51)多克隆抗体Polyclonal Antibody to RAD51 Homolog (RAD51)
kl751Hu01RAD23同源物B(RAD23B)多克隆抗体Polyclonal Antibody to RAD23 Homolog B (RAD23B)
kl797Hu01Pim-2原癌基因(PIM2)多克隆抗体Polyclonal Antibody to Pim-2 Oncogene (PIM2)
kl859Hu01基质重塑关联蛋白5(MXRA5)多克隆抗体Polyclonal Antibody to Matrix Remodelling Associated Protein 5 (MXRA5)
kl861Hu01粘蛋白13(MUC13)多克隆抗体Polyclonal Antibody to Mucin 13, Cell Surface Associated (MUC13)
kl886Hu01层粘连蛋白受体1(LAMR1)多克隆抗体Polyclonal Antibody to Laminin Receptor 1 (LAMR1)
kl892Hu01角蛋白81(KRT81)多克隆抗体Polyclonal Antibody to Keratin 81 (KRT81)
kl088Hu01Dickkopf相关蛋白4(DKK4)多克隆抗体Polyclonal Antibody to Dickkopf Related Protein 4 (DKK4)
kl088Mu01Dickkopf相关蛋白4(DKK4)多克隆抗体Polyclonal Antibody to Dickkopf Related Protein 4 (DKK4)
kl116Hu01Clock同源物(CLOCK)多克隆抗体Polyclonal Antibody to Clock Homolog (CLOCK)
kl166Hu01Bcl2样蛋白11(BCL2L11)多克隆抗体Polyclonal Antibody to Bcl2 Like Protein 11 (BCL2L11)
kl200Hu01二氢二醇脱氢酶2(DDH2)多克隆抗体Polyclonal Antibody to Dihydrodiol Dehydrogenase 2 (DDH2)
kl201Hu01醛糖还原酶相似蛋白1(ARL1)多克隆抗体Polyclonal Antibody to Aldose Reductase Like Protein 1 (ARL1)
kl258Hu01封闭蛋白9(CLDN9)多克隆抗体Polyclonal Antibody to Claudin 9 (CLDN9)
kl264Hu01E1A激活基因阻遏子1(CREG1)多克隆抗体Polyclonal Antibody to Cellular Repressor Of E1A Stimulated Genes 1 (CREG1)
kl264Mu01E1A激活基因阻遏子1(CREG1)多克隆抗体Polyclonal Antibody to Cellular Repressor Of E1A Stimulated Genes 1 (CREG1)