Quantity size:

0.2ml

Concentration:

1mg/ml 死亡相关蛋白6/Fas死亡区相关蛋白抗体  Buffer = 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Background:

Acts as an adapter protein in a MDM2-DAXX-USP7 complex by regulating the RING-finger E3 ligase MDM2 ubiquitination activity. Under non-stress condition, in association with the deubiquitinating USP7, prevents MDM2 self-ubiquitination and enhances the intrinsic E3 ligase activity of MDM2 towards TP53, thereby promoting TP53 ubiquitination and subsequent proteasomal degradation. Upon DNA damage, its association with MDM2 and USP7 is disrupted, resulting in increased MDM2 autoubiquitination and consequently,死亡相关蛋白6/Fas死亡区相关蛋白抗体 MDM2 degradation, which leads to TP53 stabilization. Proposed to mediate activation of the JNK pathway and apoptosis via MAP3K5 in response to signaling from TNFRSF6 and TGFBR2. Interaction with HSPB1/HSP27 may prevent interaction with TNFRSF6 and MAP3K5 and block DAXX-mediated apoptosis. In contrast, in lymphoid cells JNC activation and TNFRSF6-mediated apoptosis may not involve DAXX. Seems to regulate transcription in PML/POD/ND10 nuclear bodies together with PML and may influence TNFRSF6-dependent apoptosis thereby.死亡相关蛋白6/Fas死亡区相关蛋白抗体 Down-regulates basal and activated transcription. Seems to act as a transcriptional corepressor and inhibits PAX3 and ETS1 through direct protein-protein interaction. Modulates PAX5 activity. Its transcription repressor activity is modulated by recruiting it to subnuclear compartments like the nucleolus or PML/POD/ND10 nuclear bodies through interactions with MCSR1 and PML, respectively.

死亡相关蛋白6/Fas死亡区相关蛋白抗体Also known as:

BING 2; BING2; DAP 6; DAP6; Death associated protein 6; Fas death domain-associated protein; Death domain associated protein 6; EAP 1; EAP1; ETS1 associated protein 1; Fas death domain associated protein; hDaxx; MGC126245; MGC126246; DAXX_HUMAN.

Specificity:

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Rabbit Polyclonal IgG, affinity purified by Protein A.

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Reacts with: Human, Mouse, Rat, Dog, Pig, Cow, Rabbit, Sheep, .

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Immunogen: KLH conjugated synthetic peptide derived from human DAXX.

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死亡相关蛋白6/Fas死亡区相关蛋白抗体Predicted Molecular Weight: 82kDa.

Storage:

Shipped at 4℃, Store at -20℃ (Avoid repeated freeze/thaw cycles).

Application:

WB=1:100-500  ELISA=1:500-1000  IHC-P=1:100-500  IHC-F=1:100-500  IF=1:100-500   
Not yet tested in other applications. 
Optimal working dilutions must be determined by the end user.

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kl044Po01生长激素(GH)多克隆抗体Polyclonal Antibody to Growth Hormone (GH)

kl044Eq01生长激素(GH)多克隆抗体Polyclonal Antibody to Growth Hormone (GH)

kl044Ga01生长激素(GH)多克隆抗体Polyclonal Antibody to Growth Hormone (GH)

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kl266Mu01胰高血糖素(GC)多克隆抗体Polyclonal Antibody to Glucagon (GC)

kl266Ra01胰高血糖素(GC)多克隆抗体Polyclonal Antibody to Glucagon (GC)

kl438Hu01促生长激素释放激素(GHRH)多克隆抗体Polyclonal Antibody to Growth Hormone Releasing Hormone (GHRH)

kl438Mu01促生长激素释放激素(GHRH)多克隆抗体Polyclonal Antibody to Growth Hormone Releasing Hormone (GHRH)

kl438Ra01促生长激素释放激素(GHRH)多克隆抗体Polyclonal Antibody to Growth Hormone Releasing Hormone (GHRH)

kl438Po01促生长激素释放激素(GHRH)多克隆抗体Polyclonal Antibody to Growth Hormone Releasing Hormone (GHRH)

kl438Bo01促生长激素释放激素(GHRH)多克隆抗体Polyclonal Antibody to Growth Hormone Releasing Hormone (GHRH)

kl438Cp01促生长激素释放激素(GHRH)多克隆抗体Polyclonal Antibody to Growth Hormone Releasing Hormone (GHRH)

kl409An01血红蛋白(HB)多克隆抗体Polyclonal Antibody to Hemoglobin (HB)

kl409Ha01血红蛋白(HB)多克隆抗体Polyclonal Antibody to Hemoglobin (HB)

kl737Ge01吲哚乙酸(IAA)多克隆抗体Polyclonal Antibody to Indole 3 Acetic Acid (IAA)

kl091Hu01轻肽网格蛋白B(CLTB)多克隆抗体Polyclonal Antibody to Clathrin, Light Polypeptide B (CLTB)

kl091Mu01轻肽网格蛋白B(CLTB)多克隆抗体Polyclonal Antibody to Clathrin, Light Polypeptide B (CLTB)

kl091Ra01轻肽网格蛋白B(CLTB)多克隆抗体Polyclonal Antibody to Clathrin, Light Polypeptide B (CLTB)

kl462Ge01皮质醇(Cor)多克隆抗体Polyclonal Antibody to Cortisol (Cor)

kl049Gu01干扰素γ(IFNγ)多克隆抗体Polyclonal Antibody to Interferon Gamma (IFNg)

kl049Rb52干扰素γ(IFNγ)多克隆抗体Polyclonal Antibody to Interferon Gamma (IFNg)

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